- Developed annotation informed factor analysis to jointly analyse multi-omics data types. - Constructed genome-wide annotations encoding transcription factor binding affinity in regions of open chromatin and in promoter regions of genes using ATAC-seq data and TF binding motifs.Used annotation informed factor analysis to analyse scATAC-seq data and scRNA-seq data for latent components of expression. Analysed exon and intron expression profiles at the sequence level using bulk RNA-seq data in IGV to determine location of mutations and deletions in crispr knockout mice strains.R, c++, bash, samtools, bedtools, IGV