Christopher Gigliotti, Ph.D. Email & Phone Number

Gainesville, FL, US

Gainesville, Florida

• Developed process to make clinically relevant batches of nanoparticles (15 mL to 4 L).
• Conducted root cause analysis of quality issues based upon in vitro and in vivo results
• Synthesized calcium phosphosilicate nanoparticles (10-200 nm) with encapsulated phosphorylated chemotherapeutics and fluorescent imaging agents for efficacious treatment and imaging of metastatic breast cancer in bone.
• Bioconjugated the surface of nanoparticles with aptamers and antibodies for successful targeting and treatment, often with imaging, of pancreatic and breast cancer without infiltrating healthy tissue.
• Prepared hydroxyapatite paste through a co-precipitation synthesis for extrusion freeform fabrication of bone scaffolds by applying powder processing and colloidal dispersion principles and techniques.
• Optimized 3D printing parameters by applying design of experiment approaches to increase spatial resolution to mimic structural complexity of bone tissue with controlled pore sizes of 200 um.

• Focused on the synthesis/bioconjugation and characterization of biocompatible calcium phosphosilicate nanoparticles as a delivery system for chemotherapeutics and early diagnosis.
• Independently designed, tested, and implemented a protocol for quantifying residual Igepal CO-520 via dynamic surface tensiometry with lower limit of detection to 1 uM.
• Employed pancreatic cancer PANC-1 cell line to investigate cytotoxic effects of residual amphiphile, Igepal CO-520, used in synthesis of CPSNPs and efficacy of drug-loaded nanoparticles.
• Constructed pseudo ternary phase diagram for the water/cyclohexane/Igepal CO-520 water-in-oil emulsion system used to synthesis calcium phosphosilicate nanoparticles.

• Shadowed Superintendents and Project Managers to acquire management skills
• Acquired knowledge in designing and developing residential and commercial properties

Doctor Of Philosophy - Phd, Bioengineering, 3.96

Graduate Certificate, Translational Sciences

Bachelor Of Science (B.S.), Bioengineering, 3.49

Activities and Societies: Alpha Delta PhiBachelors of Science in Bioengineering with a Materials Science Option