Christopher Pedigo Email & Phone Number

Cambridge, Ma, Us

Cambridge, Massachusetts, United States

Principal Scientist in the Regeneration Medicine Group. Biology and Project Team lead for programs encompassing multiple disease areas and indications including but not limited to the following organs: liver/NASH/MASH, lung/IPF, eye, adipose/obesity tissue. Test mRNA therapeutics with epigenetic controllers in vitro with a team of Research Associates and manage CROs for in vivo work. Develop in vitro packages to support DC candidates.

A member of the editorial board of Frontiers in Endocrinology.

Acting editor for the Frontiers in Medicine: Nephrology subsection "Podocyte and Tubule OPATHIES".

Cambridge, Massachusetts, United States

Studied Chronic Kidney Disease (CKD) and rare kidney diseases (Glomerular Disease- FSGS, PKD) using CROs and internal resources. Biology team lead for an early program, maintaining times lines, ensuring scientific rigor for Go/No Go decisions and working with CROs. Actively collaborated in Target Discovery and Validation(TDV) in cross-functional teams (including pharmacologists, drug discovery researchers, computation biologists) and performed initial experiments. Established method for biomarker validation from clinical trial samples and worked with CRO to establish qualified method.

Uniondale, Ny

Led in vitro exploratory biology team, with five direct reports, to perform preclinical studies in lung, liver and kidney models. Team involved in Target Discovery and Validation, analysis of in vivo tissue samples, assay development, platform development, etc. Work with CROs to perform kinase testing, determine kinome-wide selectivity, plasma stability, P-gp efflux, liver microsome stability, etc. Oversee in vivo studies in glomerular disease and fibrotic diseases (lung, liver, kidney). Lead the in vitro exploratory biology group to test mechanism of action, biomarker and pharmacodynamic (PD) studies. Composed study reports to support IND-filing.

Provided consultations to various organizations including CROs and pharmaceutical companies. Used a multidisciplinary and translational medicine approach to provide feedback on projects and perform problem solving on applications of new topics and technologies.

New Haven, Connecticut

Performed experiments and analyzed data from in vitro, in vivo and ex vivo experiments. Studying genetic models of glomerular disease Focal Segmental Glomerulosclerosis (FSGS), autosomal dominant polycystic kidney disease (ADPKD, PKD1) and chronic kidney disease. Use data mining and bioinformatic techniques to identify novel targets for treatment of diseases of the podocyte and tubule. Unique skills learned - Culture of primary cells - Live cell imaging of primary cells -Generation and phenotyping of BAC transgenic animals - Confocal microscopy - CRISPR/Cas9 to generate knockout cell lines - CRISPR Knockout Screening in cell lines

Miami/Fort Lauderdale Area

Studied the role of lipid metabolism in podocytes in glomerular disease, including but not limited to Diabetic Kidney Disease (DKD), Focal Segmental Glomerulosclerosis (FSGS) and Alport Syndrome (Collagenopathies). Received American Heart Association Funding - Predoctoral Fellowship. Published first author papers in Journal of the American Society of Nephrology (JASN) and Journal of Clinical Investigation(JCI). Several unique skills obtained -(1) utilized Opera High Content screening system for cell phenotypic assays (2) Generation of transgenic mice

Postdoctoral Research, Nephrology

Introduction To Project Management Certification, Project Management

Doctor Of Philosophy (Phd), Molecular And Cellular Pharmacology

Forensic Molecular Bilogy, Forensic Science: Molecular Biology

Activities and Societies: Tutor - Math and Science Resource Center