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Energetic R&D leader in pharmaceutical analysis and development, nanoparticle invention/control, and material science. Experience in biotechnology, performance materials and pharma industries. Fundamental application of physical chemistry perspective to product development, problem solving and innovation. Architect of high performing organizations. Experienced functional leader of analytical development, preformulation, material characterization, and formulation science. Accomplished in strategic business development. Experienced, inspirational project manager. Successful leader of external relationships (CMO and CRO) as both customer and provider. Helping build company strategy and direct research and development activities to achieve company goals.Technical Specialties: Method Development for chemical and physical analysis including separation science (HPLC, HPLC/MS, CE, ion chromatography, ultracentrifugation etc.), mass transport and diffusion (e.g. single and multistage dissolution w/wo dialysis), high energy solids control (e.g. nanomaterials, co-crystals, precipitation inhibition); colloid formation and stabilization; elemental analysis (e.g. ICP/OES, MS); time domain and angular light scattering for phase and particle analysis; optical and magnetic spectroscopy for surface and material characterization; calorimetry; powder, granule, and compact surface/pore distribution analysis via gas adsorption and mercury intrusion porosimetry; stress/strain analysis of solids and semi-solids via force in compression/force in tension analysis; tensile strength of solids and semisolids
Jarndyce And Jarndyce, Llc
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Scientific Advisor: Pharmaceutical Development And Analysis, Nanostructures, Material ScienceJarndyce And Jarndyce, LlcCambridge, Ma, Us
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Director, Analytical And Preformulation SciencesSage Therapeutics 2018 - 2023Cambridge, MaDeveloped physiochemical measurements and biopharmaceutical in silico calculations to guide clinical formulation technology:• Rapid, material sparing, high accuracy chromatography for log P of discovery compounds• Clarification, detection, and interpolation calculations for solubility via chromatography with charged aerosol detection (to 0.3 ppb LOQ) • Food effect modeling (after Sugano) as function of dose and polymorph via Dose Number (Do), Dissolution Number (Dn), and Permeation Number (Pn )• Steady state flux measurements for transdermal, buccal, and nasal tissue -
Lead ScientistCabot Corporation 2010 - 2018Discovery and development of nanoparticles and nanodispersions with new functionalities and applications. Current efforts include novel Cabot composites for enhanced bioavaliability and interfacial hydrophobic/hydrophilic control on nano- and macroscopic scale. -
Director Of Pharmaceutical And Analytical SciencesTransform Pharmaceuticals A Johnson & Johnson Company Jan 2006 - Jan 2010Lexington, MaCompany strategy via TPI Management TeamSite responsibility for directing J&J PRD Early Development (ED) activities : scientific and resouce planning. Steady state = 30+ compounds.Director of Pharmaceutical and Analytical Sciences : responsible for small molecule preformulation development, biopharmaceutics/bioenhancement, and product specification/analytical development. Professional development of 20+ scientists and engineersCompany, departmental, and capital budget reponsibility -
Associate Research FellowPfizer Global R&D 2002 - 2006Group Leader: Method development - HPLC and all others. Chemical and physical characterization of drug substances and drug products in experimental and commercial formulations. Prepare/review scores of FDA and global submissions. Global analytical lead PAI and postapproval : Lyrica Nanoparticulate formation via fluid cavitation/shear/impact: processing, stabilization and characterization. Mass transfer parameter measurements in submicron particles.Elasticity, tensile strength and porosity of (ribbon) compacts, modeling diffusion vs. volumetric erosion API release; Kinetic stability of self-emulsifying drug delivery (SEDD) ensembles. -
Research FellowMerck Research Laboratory 1998 - 2002Group Leader: Method development - HPLC and all others for chemical and physical characterization of drug products in experimental and commercial formulations. Physical stabilization of nanosuspension formulation via surface active/polymeric modification.Moisture initiated deformation and phase modification of lyophilized formulations; molecular self assembly and lipophilic phase/particulate formation on stability; radical generation/oxidation via gamma radiation in polymeric packaging (EPR detection). -
Assistant Professor, Physical ChemistryUniversity Of North Carolina, Greensboro 1995 - 1998Built laboratory to collect time-resolved ultrasonic emission from nanosecond laser initiated reactions; photoacoustic calorimetry. These measurements quantify reaction kinetics, reaction enthalpies, and conformation dynamics. Projects include: (1) nanosecond-millisecond Na+/K+ ATPase conformational dynamics of ligand binding reactions, and (2) uni- and bimolecular deactivation mechanisms of excited electronic states in highly conjugated porphyrin arrays
Christopher Galli Skills
Christopher Galli Education Details
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University Of Maryland Baltimore County (Umbc)B.S.
Frequently Asked Questions about Christopher Galli
What company does Christopher Galli work for?
Christopher Galli works for Jarndyce And Jarndyce, Llc
What is Christopher Galli's role at the current company?
Christopher Galli's current role is Scientific advisor: pharmaceutical development and analysis, nanostructures, material science.
What is Christopher Galli's email address?
Christopher Galli's email address is ch****@****orp.com
What schools did Christopher Galli attend?
Christopher Galli attended Harvard Business School, Yale University, University Of Pennsylvania, University Of Maryland Baltimore County (Umbc).
What skills is Christopher Galli known for?
Christopher Galli has skills like Analytical Chemistry, Characterization, Hplc, Spectroscopy, R&d, Chemistry, Drug Delivery, Materials Science, Organic Chemistry, Research And Development, Laboratory, Nanomaterials.
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