Darin Lee Email & Phone Number

San Diego, California, United States

Greater San Diego Area

Greater San Diego Area

Downstream technical lead for protein purification, process development and manufacturing. Provide CDMO oversight of drug substance, placebo, and drug product manufacture including tech transfer, process development and scale up to supply Resolaris and iMod.Fc clinical trials.Conduct and supervise in-house lab-scale protein purification work to supply appropriate product quality, quantity and delivery timing for research stage programs, from microbial and mammalian production… Show more Downstream technical lead for protein purification, process development and manufacturing. Provide CDMO oversight of drug substance, placebo, and drug product manufacture including tech transfer, process development and scale up to supply Resolaris and iMod.Fc clinical trials.Conduct and supervise in-house lab-scale protein purification work to supply appropriate product quality, quantity and delivery timing for research stage programs, from microbial and mammalian production sources.Contribute to CMC sections of regulatory submission documents Show less

Conjugated and purified proteins containing non-native amino acids to support in-house research activities

Investigated and addressed issues with plasmid DNA purification process.Developed monoclonal antibody purification processes to supply in-house customers.Scaled up enzyme purification for in-house high-throughput screening studies.

Developed conjugation and purification formulation process for PEGylated proteins. Developed methods for analyzing PEGylation reaction and purified products.NSERC Industrial Postdoctoral Fellow

Studied pH-dependent membrane disruption and fusion activity of liposomes designed for intracellular drug delivery

Produced cationic antimicrobial peptides by solid-phase peptide synthesis

Ph.D., Biochemistry

B.Sc., Biochemistry