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@imagesofjazz.com
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David Rothstein is listed as Consultant for Biotech and Pharma at David Rothstein Consulting LLC, based in Lexington, Massachusetts, United States. AeroLeads shows a work email signal at imagesofjazz.com, phone signal with area code 773, and a matched LinkedIn profile for David Rothstein.
David Rothstein previously worked as Vice President Biology at Tetraphase Pharmaceuticals and Senior Director, Drug Discovery, Preclinical Development at Activbiotics, Inc.. David Rothstein holds Ph.D., Microbiolgy And Molecular Biology from Tufts University School Of Medicine.
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Ph.D. in Microbiology and Molecular Biology. Extensive experience in directing junior and senior scientific personnel, as well as in conceiving, planning, and executing research programs. Leader of preclinical activities to file IND for antibacterial development candidates. Project Leader of antibacterial and antifungal multi-disciplinary programs to discover novel antibiotics. Principal Investigator of grants to discover and develop antibacterial agents. Expertise in genetics, microbial physiology, and molecular biology, including recombinant DNA technology and genetic engineering as well as microbiology of diverse organisms including aerobic and anaerobic pathogenic bacteria and pathogenic fungi.Specialties: Discovery and development of antibacterial agents and anti-fungal agents.Development of other pharmaceuticals.
Listed skills include Molecular Biology, Development, Recruitment, Design, and 7 others.
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Preclinical studies from drug discovery through definitive toxicology and safety pharmacology studies. Molecular biology, microbiology, mode of action, in vitro activity, in vivo efficacy, toxicology studies.Anti-infective agents, allergic rhinitis.
In vitro activity, in vivo efficacy of novel antibacterial agents.mode of action studies novel antibacterial agents.Monitored ADME, safety pharmacology, definitive toxicology studies.Member of management team.
In vitro activities of novel antibacterial compounds (rifamycins with extraordinary potency against Chlamydia).In vivo efficacy.Analysis of resistance mechanisms and development, in vitro and in vivo.Mode of action of novel antibacterial compounds.ADME.Member of management team.
Principal Investigator of grants funded by the Cystic Fibrosis Foundation.Directed microbiological research toward teh development of 3 dental therapeutic agents.
Initiated Antibacterial Program, including design of program and recruitment of scientists.Designed and executed high-throughput target-based screens to identify novel antibacterial and anti-fungal compounds.Played a leading role in the consummation of a multi-million dollar alliance with my former employer (Lederle laboratories, now part of Wyeth-Ayerst Research)
Project Leader for tetracycline research; coordinated the efforts of several research groups (medicinal and analytical chemists, formulations scientists, clinical microbiologists, pharmacologists, molecular biolgists) developing novel tetracyclines; tigecycline was eventually approved.Designed and implemented several sensitive screening systems for the discovery of novel antibacterials.Analyzed the molecular genetics of tetracycline resistance mechanisms.Molecular genetics of the… Show more Project Leader for tetracycline research; coordinated the efforts of several research groups (medicinal and analytical chemists, formulations scientists, clinical microbiologists, pharmacologists, molecular biolgists) developing novel tetracyclines; tigecycline was eventually approved.Designed and implemented several sensitive screening systems for the discovery of novel antibacterials.Analyzed the molecular genetics of tetracycline resistance mechanisms.Molecular genetics of the bacteria that produces calicheamicin, a potent anti-tumor agent, and conceived of a method to produce modified forms of calicheamicin. Show less
Expression systems in bacteria.Inducible systems by physiological switch.Molecular genetics of Costridia (ethanol producers)
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David Rothstein works for David Rothstein Consulting LLC.
David Rothstein is listed as Consultant for Biotech and Pharma at David Rothstein Consulting LLC.
AeroLeads has found 1 work email signal at @imagesofjazz.com for David Rothstein at David Rothstein Consulting LLC.
AeroLeads has found 2 phone signal(s) with area code 773 for David Rothstein at David Rothstein Consulting LLC.
David Rothstein is based in Lexington, Massachusetts, United States while working with David Rothstein Consulting LLC.
David Rothstein has worked for David Rothstein Consulting Llc, Tetraphase Pharmaceuticals, Activbiotics, Inc., Periodontix, Inc., and Millennium Pharmaceuticals.
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David Rothstein holds Ph.D., Microbiolgy And Molecular Biology from Tufts University School Of Medicine.
David Rothstein is listed with skills including Molecular Biology, Development, Recruitment, Design, Scientists, Biotechnology, Genetics, and Research.
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