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David Shaya is listed as Lead discovery protein biophysics, biochemistry | Binding/Inhibition assay development | Hit-to-Lead | SPR | Structure Biology at Exelixis, a company with 51 employees, based in San Francisco Bay Area, United States, United States. AeroLeads shows a work email signal at exelixis.com and a matched LinkedIn profile for David Shaya.
David Shaya previously worked as Senior Scientist I/II at Exelixis and Senior Scientist, lead drug discovery at Bluelight Therapeutics, Inc.. David Shaya holds Postdoctoral Research Scholar, Structural Biology - Ion Channels from University Of California, San Francisco.
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AeroLeads found 1 current-domain work email signal for David Shaya. Compare company email patterns before reaching out.
Protein Biochemist/Biophysicist with 8 years experience in Biotech and drug discovery Accomplished, versatile, multifaceted and energetic PhD scientist with demonstrated hands-on experience implementing protein biophysical and biochemical techniques for drug discovery and study of difficult protein targets.- Demonstrated success developing and implementing novel biophysical methodologies for protein- small molecule and protein-protein interactions in drug discovery (8 years)- Extensive background in structural biology (X-ray crystallography, 13 years), rational construct design and protein expression-purification-characterization- Collaborative, passionate and enthusiastic team player that thrives in a diverse multifunctional environment working with a sense of urgency- Goal-oriented leader, focused and organized, with demonstrated capacity to conceive, design and execute projects with a high commitment to patients Areas of Expertise:Drug discovery: HTS screening ♦ Hit to lead assay development ♦ Fluorescent techniques (FRET - HTRF allosteric/orthosteric probe displacement) ♦ Mechanism Of Action ♦ DNA encoded library screens ♦ Activity assays (ADP-Glo, GTPase, DiFMUP, ELISA, enzyme kinetics etc..)♦ SPR ♦ Protein biochemistry: Soluble/Membrane Protein Expression and Purification ♦ Protein Quality Control Analysis PAGE, SEC, chromatography, CD, dynamic/static Light Scattering, Mass Spec., Chemical Cross-linking, Thermal Denaturation Assays (DSF) ♦ Protein engineering and construct rational design ♦ Protein labeling and conjugation Leadership: Effective communication skills ♦ Efficient Project time Management to meet goals on marked time frames ♦ Team leadership ♦ Creative problem solving ♦ Synergistic across various disciplines
Listed skills include Protein Expression, Protein Purification, Protein Chemistry, Molecular Biology, and 30 others.
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Alameda, California, US
Sr. Scientist I/II, Lead discovery - developed and executed successful biophysical and biochemical assays for high-throughput screening, effective SAR campaigns and target MOA characterization.♦ Lead discovery project leadership in cross-functional teams, responsible for project aspects from conceptualizing screening strategies to a successful execution of.
South San Francisco, CA, US
I Leveraged structure-driven platform to develop novel therapeutic application for high-value drug targets. I played a central role in developing and validating BlueLight’s Second Harmonic Generation (SHG) technology to study protein conformational changes upon ligand application. Subsequently, I successfully executed the first SHG high-throughput screen.
South San Francisco, CA, US
♦ I established large scale protein expression and labeling to generate and QC proteins enabling HTS.♦ I designed and executed orthogonal assays for hit validation including ADP-Glo, DiFMUP and HTRF assay.♦ I biophysically characterized protein targets and developed activity assays for early discovery targets.
South San Francisco, CA, US
♦ I worked with external pharma and academic partners on key collaboration projects.♦ I adapted the SHG technology and workflows to characterize novel hard-to-drug targets and membrane protein samples (RAS, GPCR).
South San Francisco, CA, US
♦ I launched 2 novel surface products: Phosphatidylserine (PS) and biotinylated surfaces expanding the company applicability portfolio. This included developing model proteins to develop, test and validate these surfaces (used in SHG technology application for RAS and biotinylated targets).♦ Managed construct design, protein expression and purification in.
Los Alamos, NM, US
Postdoctoral Research Associate, Structural studies of Multi-Drug-resistance Efflux pumps complexes♦ I screened efflux pumps components cloning and expression optimization to identify high over-expressing, properly folded 24-TM inner membrane transporter constructs leading to crystallizable constructs.♦ Membrane protein engineering and construct.
San Francisco, California, US
American Heart and Stroke Assoc. Postdoctoral Research Fellow (2011-2013), Structural and Biophysical Investigations of Sodium Channels (membrane spanning proteins)♦ Using innovative protein engineering, I created high over-expressing tetrameric, active ‘pore-protein’ ion channels by removing the voltage sensor and expressing the ion permeation pathway of.
Ottawa, Ontario, CA
Structural and Kinetic Studies of Glycosaminoglycan (GAG) Degrading Enzymes♦ Structural and functional analysis of 3 heparin-degrading enzymes. I solved the 3D structures of 3enzymes mastering protein expression, purification, crystallization, labeling with heavy-atom derivatives and Se-met incorporation, X-ray data collection, 3D-model building and PDB.
Rehovot, Hamerkaz, IL
Biochemical and structural characterization of an engineered 3‐finger snake toxin♦ Protein engineering of a chimera protein inhibitor for Acetylcholinesterase.♦ Protein purification enzyme activity assay.
Other employees you can reach at exelixis.com. View company contacts for 51 employees →
Vaishali Sangale
Colleague at Exelixis
Tracy, California, United States, United States
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Owen Baxter
Colleague at Exelixis
Ghana, Ghana
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Erin Niemeyer
Colleague at Exelixis
Henderson, Nevada, United States, United States
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Andreas Kaklios
Colleague at Exelixis
Greece, Greece
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Dawood Tariq
Colleague at Exelixis
Saudi Arabia, Saudi Arabia
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Alex Charruyer-Reinwald
Colleague at Exelixis
Alameda, California, United States, United States
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Lu Ding
Colleague at Exelixis
San Francisco, California, United States, United States
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James Corrado
Colleague at Exelixis
Greater Philadelphia, United States, United States
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Chuck Forcier
Colleague at Exelixis
Metro Jacksonville, United States, United States
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Senthil Balusamy
Colleague at Exelixis
Pleasanton, California, United States, United States
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Quick answers generated from the profile data available on this page.
David Shaya works for Exelixis.
David Shaya is listed as Lead discovery protein biophysics, biochemistry | Binding/Inhibition assay development | Hit-to-Lead | SPR | Structure Biology at Exelixis.
AeroLeads has found 1 work email signal at @exelixis.com for David Shaya at Exelixis.
David Shaya is based in San Francisco Bay Area, United States, United States while working with Exelixis.
David Shaya has worked for Exelixis, Bluelight Therapeutics, Inc., Los Alamos National Laboratory, Ucsf, and National Research Council, Mcgill University, Montreal.
David Shaya's colleagues at Exelixis include Vaishali Sangale, Owen Baxter, Erin Niemeyer, Andreas Kaklios, and Dawood Tariq.
You can use AeroLeads to view verified contact signals for David Shaya at Exelixis, including work email, phone, and LinkedIn data when available.
David Shaya holds Postdoctoral Research Scholar, Structural Biology - Ion Channels from University Of California, San Francisco.
David Shaya is listed with skills including Protein Expression, Protein Purification, Protein Chemistry, Molecular Biology, Purification, Pcr, Biochemistry, and Dna.
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