Manage team of five permanent staff (technologists and scientist) within the Biochemistry Platform, Analytical Sciences Dept. North America (AnSci-NA). Oversee work of additional contingent scientists to support agile response to changes in workload demand.Support Platform Director to develop mid to long term staffing and CAPEX plan and develop staff to ensure continuous performance in delivering NV and licensed product portfolio objectives while expanding expertise in novel analytical technologies.Lead analytical test strategy in areas of protein characterization and biophysics for clinical development of new vaccine candidates, for development and validation of process changes for licensed products and in support of QC and IA investigations.Lead method development, qualification/validation and release/characterization testing of new vaccine candidates (such as Meningitis and Covid-19 projects) using various liquid chromatography, electrophoresis, particle sizing and biophysical characterization methodologies.Subject matter expert in area of protein biochemistry, responsible for analytical test strategy development, execution and regulatory submission for clinical trials and non-routine testing support for process changes for licensed commercial vaccines. Area manager for GMP QC testing lab as well as sample management and test forecasting/scheduling for all of local Toronto Vaccine R&D Department.Provided technical scientific expertise where applicable as Biochemistry platform representative at cross-department interfaces ( such as R&D Bioprocess development, R&D Quality and Industrial Affairs) and technical workshops (vaccine development QbD, project risk assessments, scenario planning and long-range project planning).

North American Analytical R&D - Biochemistry Platform.Lead for the analytical method development of AAA, HPLC/UPLC, UV andLC-MS based quantitative assays for release and stability testing of biopharmaceuticalproducts in development, including viral and protein-based vaccines as well as aluminumand biomolecular based adjuvants (oligonucleotide, lipid and oil emulsions).• Primary author of method development reports, SOP, qualification plans and qualificationreports for analytical test methods for new vaccine projects.• Review and approve non-GMP testing results to support process development decisions.• Provided technical scientific expertise where applicable as representative for BiochemistryPlatform at cross-department interfaces (Bioprocess R&D, Pre-clinical Research, QC,Commercial manufacturing technologies).

North American Analytical R&D Biochemistry Platform.Lead teams of technologists in the analytical method development of HPLC/UPLC and UVbased quantitative assays for release and stability testing of biopharmaceutical products.• Provided technical scientific expertise to analytical working group to develop testing andrisk mitigation strategy of global new vaccine projects in clinical development.• Review and provide comments to Pharmacopeia revision in area of expertise.• Performed analytical testing in compliance with a GMP environment.• Coordinated and provided technical expertise to outsourcing of assay development (HPLC, GC),qualification and testing to CROs.

• Among select group of clinicians and scientists, discussed and brainstormed latest developments in radiation biology and translational oncology research. • Received focused training on research translation and scientific communication from top leaders in the scientific and cancer research community from across Canada.• Acted as session leader for the CIHR – Cross STHIR Training Day, and as a program representative for high school student outreach – awarded Representation Prize, 2013. • Participated and led year long group projects focused on research translation and scientific communication – awarded Team Research Proposal Prize, 2013.

Supervisor – Dr. Shana O. Kelley (Professor, Dept. of Pharmacy).• Used chemical biology techniques to develop peptide-conjugated versions of common chemotherapeutic agents (2), imparting improved efficacy and evasion of clinical resistance mechanisms. • Created peptide-conjugated versions of common chemotherapeutic agents (2).• Developed assays to probe cellular effects of drug treatment using flow cytometry and cell-based functional and cytotoxicity assays.• Designed and directed preclinical mouse model studies (2) of drug efficacy and toxicity.• Managed collaborative projects with both local and international researchers.

Co-supervisors – Dr. R. Scott Prosser (Professor, Dept. of Chemistry, University of Toronto, Mississauga)• Developed and lead collaborative project to develop novel NMR based assay for investigation of membrane protein-detergent interactions.• Provided expert support to fellow trainees in the application of fluorescence spectroscopy and circular dichroism (CD) techniques to protein characterization.• Member of steering committee for PrioNet/ CHIR Protein Folding International Conference.

Tutorial session leader: Biochemistry I: Proteins, Lipids and Metabolism.(Department of Biochemistry)• Lead help sessions and review lectures for class enrolments of up to ~1000 students.• Provide online support for questions related to course material.• Aid in preparation and marking of midterm and exams.• Received Department of Biochemistry Teaching Assistant Achievement Award, 2011.Lab Demonstrator: Laboratory Course in Biochemical Techniques.(Department of Biochemistry) • Trained and supervised undergraduate students in modern laboratory techniques.• Conducted lectures explaining theoretical basis of such techniques.• Evaluated and provided constructive feedback to students on formal lab reports.• Received Department of Biochemistry Teaching Assistant Achievement Award, 2008.Lab Demonstrator: Introductory Organic Chemistry.(Department of Chemistry)

Supervisors – Dr. Stephan Matilé (Professor) – Dr. Aurélien Roux (Professor).• Provided input and expertise for (Switzerland) National Centre of Competence in Research: Chemical Biology in the development of cellular assays for uptake and visualization of a novel class of polymer-based cell delivery nanotechnology.• Trained Postdoctoral chemists on mammalian cellular analysis methods.

Thesis: Detergents as membrane-mimetic media for structural characterization of membrane proteins.Supervisor – Dr. Charles M. Deber (Professor, University of Toronto; Senior Scientist, Hospital for Sick Children)• Developed novel upstream and downstream protocols to express and purify libraries of recombinant proteins with varying characteristics.• Performed biophysical characterization of protein/peptide structure, function and interaction with detergent and lipid formulations. • Independently prepared scientific manuscripts for publication in peer reviewed journals, as well as reports and presentations for a variety of audiences.• Managed and trained fellow students on technical use of laboratory instrumentation.• Developed ad utilized a wide range of modern biophysical, molecular biology and biochemistry techniques including; HPLC, ELISA, CD, Flourecence Spectroscopy, SDS-PAGE, Western blotting, molecular cloning, solid-phase peptide synthesis, protein tagging/modification, protein quantification/purification and NMR.• Awarded over $110,000 in scholarships, bursaries and awards including: Mary H. Beatty Fellowship, NSERC Canadian Graduate Scholarship (Master’s), NSERC Canadian Graduate Scholarship (Doctorial), CIHR Student Fellowship (Training Program in Protein Folding).

Lab Demonstrator: Introductory Chemistry(Department of Chemistry)

Department of Biochemistry and Biomedical Sciences, summer 2004.Supervisor – Dr. Graham A. McGibbon (Assistant Professor)• Assisted in ordering and set up of equipment for modern protein chemistry lab facilities.• Developed heterologous protein expression and purification protocols.Department of Chemistry, summer 2002,2003Supervisor – Dr. Adam P. Hitchcock (Professor)• Operated, maintained and repaired specialized experimental equipment (Inner Shell Electron Energy Loss Spectrometer).• Authored initial version of user manual for subsequent students.• Converted existing locally hosted experimental database to web-based platform.• Contributed to work published in four peer reviewed articles.