Dirk Smith Email and Phone Number
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I believe in the power of science to disentangle biological complexity and improve human life. During my 25 year career in the biotechnology industry I’ve been privileged to direct original research and lead therapeutic programs along the difficult but satisfying path from discovery to clinical testing. High quality science does not have shortcuts and drug development has its own set of rules, however creativity and an open mind are as important as rigor. I've also learned not to underestimate the power of working effectively as part of a high quality team.More about me:Deep expertise in core disciplines of drug development, including target rationale, lead identification, large and small molecule pharmacology and biomarker developmentStrong foundation in immunology and human genetics with experience in respiratory disease, oncology, autoimmune and inflammation therapeutic areasExtensive leadership experience, including oversight of asthma research and patient stratification strategies at Amgen. Global Research Lead for AMG 282 (Astegolimab/MSTT1041A/RG6149), a late stage clinical antibody targeting the IL-33 receptor; Founding Partner of a fully-integrated drug development consulting group; VP, R&D for respiratory disease-focused biotech company.Over 50 published articles, 7 issued patents, frequent invitations to speak at scientific conferences and a robust worldwide scientific network
Cascadia Drug Development Group
View- Website:
- thecddg.com
- Employees:
- 8
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Founding Partner And ManagerCascadia Drug Development GroupBainbridge Island, Wa, Us
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Founding PartnerCascadia Drug Development Group Jan 2017 - PresentSeattle, Wa, UsFounding Partner and Acting Manager of a drug development consulting group providing strategic guidance and direct oversight of early therapeutic programs in immunology, oncology and other indication spaces.
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Vp, R&DAeon Respire Jan 2022 - PresentNewbury Park, Ca, UsCo-Founder and Vice President of R&D of a startup advancing a new inhaled treatment for asthma, COPD, viral infections and other respiratory diseases. -
Industry AdvisorAspect Biosystems Mar 2016 - PresentVancouver, Bc, CaIndustry advisor for a 3D bioprinting technology company that develops innovative models to enable smarter preclinical research. -
Guest LecturerUniversity Of Washington 2016 - PresentSeattle, Wa, UsI teach a course on Drug Discovery of Biologic agents for the UW Masters program in Pharmaceutical Bioengineering. -
TreasurerInflammation Research Association 2016 - Presenthttp://www.inflammationresearch.org/
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Biotherapeutics ConsultantInsight Bioconsulting Aug 2015 - Dec 2021Provide personalized consulting support to clients large or small. I solve preclinical pharmacology issues and provide strategic input to advance therapeutic portfolios.
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Scientific DirectorAmgen Mar 2013 - Aug 2015Thousand Oaks, Ca, UsGlobal Research Team Leader for two immunology programs in the clinical pipeline, including AMG 282, a first in class IL-33 pathway inhibitor.As leader of asthma research team, collaborated with clinical and business development colleagues to develop a new strategy for asthma and helped spearhead involvement in UBIOPRED, an international asthma research consortium. Also implemented novel human models of airway disease to advance therapeutic approaches targeting core phenotypes of disease.Provided vision and managed cross-functional team to champion sophisticated biomarker technologies and advance a patient stratification strategy Directed collaboration between immunology group and deCODE Genetics, an Iceland-based human genetics organizationRegularly provided critical evaluation of licensing opportunities, reviewed for scientific journals and served on advisory boards -
Principal ScientistAmgen 2008 - 2012Thousand Oaks, Ca, UsAdvanced several new research projects (novel B cell inhibition, cytokine inhibitors, genetic control of human immune responses, novel brain receptor isoform, etc.)Conducted and published independent research including the discovery of novel immune interactions and the elucidation of previously unknown human immune biology. Published several papers on novel IL-33 biology and authored highly-cited review articles.Served as project team leader to champion and advance first-in-class human antibodies from preclinical target validation and lead identification to clinical development stage Organized the Amgen/University of Washington Joint Immunology Symposium
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Senior ScientistImmunex 1996 - 2002UsMember of the Molecular Biology DepartmentCloned 4 cytokines and receptors, including IL-36 and novel IL-1 co-receptor.Devised biological screens to elucidate signaling responses and biological function of novel cytokines -
Senior Research TechnicianFred Hutch 1992 - 1996Seattle, Wa, UsPerformed research and published novel data that advanced our understanding of tumor drug resistanceDeveloped methodologies for mapping DNA:protein interactions and measuring regulation of the MDR1 gene
Dirk Smith Skills
Dirk Smith Education Details
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University Of New HampshireGenetics -
Washington State UniversityMinor In Philosophy
Frequently Asked Questions about Dirk Smith
What company does Dirk Smith work for?
Dirk Smith works for Cascadia Drug Development Group
What is Dirk Smith's role at the current company?
Dirk Smith's current role is Founding Partner and Manager.
What is Dirk Smith's email address?
Dirk Smith's email address is sm****@****ail.com
What is Dirk Smith's direct phone number?
Dirk Smith's direct phone number is +120626*****
What schools did Dirk Smith attend?
Dirk Smith attended University Of New Hampshire, Washington State University.
What are some of Dirk Smith's interests?
Dirk Smith has interest in Environment, Science And Technology, Human Rights, Arts And Culture, Health.
What skills is Dirk Smith known for?
Dirk Smith has skills like Immunology, Molecular Biology, Drug Development, Life Sciences, Biotechnology, Drug Discovery, Pharmacology, Clinical Development, Assay Development, Inflammation, Biomarkers, Cell Biology.
Who are Dirk Smith's colleagues?
Dirk Smith's colleagues are Kelly Byrnes-Blake, Jeannette Bigler, Eric Butz.
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