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At One Vector, my focus is on deploying robust data infrastructure and strategizing digital roadmaps tailored for cutting-edge Data Science services. This recent endeavor builds on a rich legacy of leading computational teams at Arrakis Therapeutics, where we pioneered RNA-targeted small molecule development through innovative computational biology and machine learning applications.My expertise lies in assembling and nurturing high-caliber teams, exemplified by forming a department of computational scientists that served as a bridge between computational methods and practical bench science. Our collective efforts facilitated an enterprise-level digital transformation, including the creation of new functions in Research Informatics and ML/AI, optimizing a multimillion-dollar budget, and empowering bench scientists with democratized analytical tools.
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Senior Director Data ScienceAscidian Therapeutics Jun 2024 - PresentBoston, Massachusetts, Us -
Principal Consultant Data ScienceOne Vector Apr 2024 - PresentCambridge, Ma, UsHelping launch Data Infrastructure and Digital Strategy Roadmapping for Data Science services -
Director Of Data Sciences (Comp Bio, Research Informatics, Ml/Ai)Arrakis Therapeutics Dec 2021 - Mar 2024Waltham, Ma, UsBuild and lead computational teams at Arrakis Therapeutics to advance the development of RNA-targeted small molecules.•. Built a department of 11 computational scientists/engineers across 3 functions headed by AD/PE-level managers: - Coach and develop talent, create opportunities for team members’ growth with a focus on becoming ‘translators’ bridging computational methods and bench science - Planned and managed a budget of $2.7 million (FY2023) focusing on cost optimization•. Lead an enterprise level digital transformation at Arrakis: - Created and shaped 2 new functions (Research Informatics and ML/AI) - Supervised creation a centralized, secure Data Lake (informatics platform) to standardize data governance and data collection/analysis in order to improve data accuracy and save FTE time of bench scientists•. Launched efforts to curate internal data into version-controlled data assets to enable state-of- the-art predictive modeling (ML/AI)•. Member of Research Leadership Team that collectively managed programs, activities, resources and performance across research organization•. Represented the scientific and business value of the company’s data and infrastructure at conferences and meetings with investors -
Associate Director Of Computational BiologyArrakis Therapeutics Dec 2019 - Dec 2021Waltham, Ma, Us•. Tripled the size of the computational biology to support internal and collaboration programs, manage priorities, and coordinate cross-functional activities•. Supported target identification and screening construct design through mining of public and internal datasets including: RNAseq, CAGE-seq, structure probing (SHAPE/DMS-MaP), and Pearl- seq•. Built and supported containerized analysis pipelines to support democratization of analysis for routine assays to bench-scientists
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Principal Scientist, BioinformaticsModerna Feb 2019 - Dec 2019Cambridge, Massachusetts, Us•. Supervised and mentored a team of 1 - 4 researchers (FTEs and contractors) responsible for performing end-to-end NGS experiments from the lab bench through analysis and visualization of results•. Created internal NGS core facility and group prior•. Co-led an internal research program including: determining deliverables for individual projects, setting timelines, advising project leaders, and communicating results to upper management•. Led research efforts to understand how structure impacts therapeutic mRNA function •. Implemented and developed internal RNA structure probing capabilities (SHAPE-MaP/DMS) using NGS•. Implemented computational structure modeling for mRNAs containing modified nucleotides•. Wrote and maintained custom NGS analysis pipelines for an AWS high-performance computing environment using Docker, Python, Jupyter, and Pandas•. Managed deliverables from external CROs and sponsored research agreements -
Senior Scientist, Molecular Biology & BioinformaticsModerna Feb 2016 - Dec 2019Cambridge, Massachusetts, UsLead a team implementing various technologies that use next-generation sequencing and computational tools in order to characterize and improve mRNA therapeutics and their biological effects.
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Scientist, Molecular Biology & InformaticsModerna May 2014 - Feb 2016Cambridge, Massachusetts, UsFounding bioinformatic scientist at Moderna Therapeutics responsible for advancing the development of the mRNA therapeutic platform: design, manufacturing, and QC processes leading to 3 publications and 2 patent applicationsLeveraged next-generation sequencing technologies and computational tools to characterize and improve mRNA therapeutics.
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Contract Content ReviewerAmerican Journal Experts Jun 2010 - Apr 2014Durham, North Carolina, UsProvided contract editing services for scientific manuscripts prior to submission to an academic journal focusing on both clarity and rigor of scientific conclusions -
Post-Doctoral Research FellowUniversity Of North Carolina At Chapel Hill Jun 2008 - Apr 2014Chapel Hill, Nc, Us• Developed genome scale technology to chemically probe RNA structure using Illumina next-generation sequencing• Wrote two successful research fellowship applications securing a total of four years of support totaling $178,000 • Created new methods for preparing and sequencings custom RNA-seq and amplicon libraries using NGS• Wrote custom computer scripts in perl, python, and bash for analyzing FASTQ files• Supervised the installation, upgrade, and use of a MiSeq• Led a collaboration to characterize the structure of three Hepatitis C Virus genomes.• Establish a structural mechanism that explains how a SNP reduces the clinical response to standard HCV therapy by altering the structure and expression of the IL28B mRNA -
Graduate StudentDuke University Aug 2001 - Dec 2007Durham, North Carolina, Us• Used RNAi technology to knock-down four human genes, confirming those genes as regulators of FGFR2 gene expression during prostate cancer progression• Used a pool of multiple siRNA duplexes targeted against different genes in order to overcome the compensatory regulation in mammalian cells where related genes are up-regulated in response to RNAi knock-down of a specific gene• Used RNA affinity chromatography to identify the protein binding sites within the FGFR2 mRNA critical to regulation of alternative splicing of FGFR2 gene• Designed, sub-cloned, and expressed a panel of targeted mutations within regulatory proteins in order to characterize functional protein domains -
Undergraduate Research AssistantUniversity Of Pittsburgh Sep 1998 - Jun 2001Pittsburgh, Pa, Us• Used random PCR mutagenesis to generate a library of mutations within a yeast transcription factor and performed a genetic screen for specific phenotypes -
InternMerck May 2000 - Aug 2000• Sub-cloned and expressed a panel of targeted mutations within a neuroreceptor in order to determine the binding affinities to both natural ligand and antagonist compounds
David Mauger Skills
David Mauger Education Details
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Duke UniversityMolecular Genetics And Microbiology -
University Of PittsburghChemistry And Biology
Frequently Asked Questions about David Mauger
What company does David Mauger work for?
David Mauger works for Ascidian Therapeutics
What is David Mauger's role at the current company?
David Mauger's current role is Head of Data Sciences.
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What is David Mauger's direct phone number?
David Mauger's direct phone number is (919) 684*****
What schools did David Mauger attend?
David Mauger attended Duke University, University Of Pittsburgh.
What skills is David Mauger known for?
David Mauger has skills like Pcr, Western Blotting, Cell Culture, Research, Rnai, Genetics, Molecular Cloning, Protein Purification, Dna Sequencing, Polymerase Chain Reaction, Next Gen Dna Sequencing, Gel Electrophoresis.
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