Dr. Amit Kumar Email & Phone Number

Hyderabad, In

Hyderabad, Telangana, India

Specialized in leveraging bioinformatics tools and statistical methods to derive meaningful insights from complex genomic datasets, with a particular focus on drug discovery.Expertise:NGS Data Analysis for Drug DiscoveryGenomic Data InterpretationVariant Calling and AnnotationStatistical Analysis and Machine LearningBioinformatics Tools and SoftwareThroughout my career, I have actively contributed to drug discovery projects, applying advanced… Show more Specialized in leveraging bioinformatics tools and statistical methods to derive meaningful insights from complex genomic datasets, with a particular focus on drug discovery.Expertise:NGS Data Analysis for Drug DiscoveryGenomic Data InterpretationVariant Calling and AnnotationStatistical Analysis and Machine LearningBioinformatics Tools and SoftwareThroughout my career, I have actively contributed to drug discovery projects, applying advanced bioinformatics techniques to identify potential drug targets, analyze target-protein interactions, and predict drug efficacy. My experience spans across various therapeutic areas, including oncology, infectious diseases, and neurodegenerative disorders.With a strong passion for advancing scientific knowledge and improving healthcare outcomes, I am dedicated to staying abreast of the latest developments in bioinformatics and genomics. My multidisciplinary background, coupled with my expertise in drug discovery, enables me to effectively collaborate with cross-functional teams and deliver valuable insights for the development of novel therapeutics.I am actively seeking new opportunities to apply my expertise in NGS data analysis and drug discovery. If you're looking for a bioinformatics professional who can contribute to cutting-edge research and drug development projects, let's connect and explore potential collaborations. Show less

New Delhi, Delhi, India

• Conducted NGS data analysis on COVID-19 samples from a specific geographical area, analyzing viral evolution patterns and genetic variations over time.• Analyzed entomological and community behaviour surveillances for malaria control across multiple funded centres in India, presenting findings and recommendations through an interactive dashboard.• Reviewed research proposals for funding allocation, ensuring scientific rigor and feasibility, managing the grant cycle from proposal… Show more • Conducted NGS data analysis on COVID-19 samples from a specific geographical area, analyzing viral evolution patterns and genetic variations over time.• Analyzed entomological and community behaviour surveillances for malaria control across multiple funded centres in India, presenting findings and recommendations through an interactive dashboard.• Reviewed research proposals for funding allocation, ensuring scientific rigor and feasibility, managing the grant cycle from proposal solicitation to post-award administration. Show less

Hyderabad Area, India

• Elucidated the molecular mechanism behind the drug-like action of peptide antagonists on a bacterial transcription terminator, Rho by computational investigation.• Established the pathway network that is under the influence of Rho-dependent termination based on the microarray and metabolomics data which would determine Rho as pleiotropic regulator.• Analysed the mass spectrometry data of novel mycobactericidal gene products from Mycobacteriophage D29 & Che12 and predicted their… Show more • Elucidated the molecular mechanism behind the drug-like action of peptide antagonists on a bacterial transcription terminator, Rho by computational investigation.• Established the pathway network that is under the influence of Rho-dependent termination based on the microarray and metabolomics data which would determine Rho as pleiotropic regulator.• Analysed the mass spectrometry data of novel mycobactericidal gene products from Mycobacteriophage D29 & Che12 and predicted their structure and function. Show less

Nampally, Hyderabad

Analyzed the mass spectrometry data and predicted the structure and function of novel mycobacteriocidal gene products from Mycobacteriophage D29 & Che12.

Puducherry, India

In brief:- F. nucleatum, an anaerobic opportunistic pathogen has been well known for its role in oral and gut infections such as periodontitis and inflammatory bowel disease (IBD). Its association with CRC progression was just then identified by different research groups but, the mechanism underlying this progression was not revealed. Hence, I predicted the possible interactions between host and F. nucleatum followed by enrichment analysis of host proteins. Taken together the previous… Show more In brief:- F. nucleatum, an anaerobic opportunistic pathogen has been well known for its role in oral and gut infections such as periodontitis and inflammatory bowel disease (IBD). Its association with CRC progression was just then identified by different research groups but, the mechanism underlying this progression was not revealed. Hence, I predicted the possible interactions between host and F. nucleatum followed by enrichment analysis of host proteins. Taken together the previous experimental studies, I hypothesized that F. nucleatum infection might enhance CRC progression by regulation of signaling cascades such as wnt/β-catenin pathway which lead to up-regulation of proinflammatory responses, oncogenes, modulation of host immune defense mechanism along with suppression of DNA repair system. With insights into the key role of F. nucleatum in several diseases, I predicted a set of druggable target proteins by implementing subtractive genomics studies. Among them, MurA enzyme that catalyzes the first committed step of peptidoglycan synthesis pathway was selected for in silico and in vitro inhibition studies. Orientin and quercetin-3-O-glucuronide (Q3G) were identified as potential inhibitors based on structure-based virtual screening (SBVS) and molecular dynamic (MD) simulation analysis. Simultaneously, I cloned the murA gene from F. nucleatum into BL21 cells and purified MurA protein with affinity column chromatography. These two compounds inhibited MurA activity in vitro with inhibitory constant (Ki) of 51.09 ± 2.06 and 9.53 ± 1.58µM, respectively. Simultaneous studies by other research group showed the inhibitory potential of Q3G on bacterial infection, which suggest that the compound can well pass through various membrane barrier and has antibacterial activity as well. Show less

Doctor Of Philosophy - Phd, Bioinformatics

Hypothesized the mechanisms involved in CRC progression due to Fusobacterium nucleatum infection by enrichment analysis of host-pathogen.

Master'S Degree, Bioinformatics, And Computational Biology, 6.7 Cgpa

Bachelor Of Science In Applied Biotechnology, Health, Medical And Technological Sciences, 1St