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Experienced research scientist in strain and enzyme engineering.• Work in a multi-disciplinary team on microbiology projects.• Expertise in molecular microbiology and host-bacterial pathogen interactions.• Excellent technical skills in bacterial genetic manipulation, molecular biology, protein science, cellular microbiology, and microscopy.• Strong communication skills: I routinely communicate experiment results and lead discussions with colleagues. I have presented my work at national and international conferences and have authored high-impact publications.
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Scientist IiManusUnited States -
Research Scientist IManus Bio Aug 2022 - PresentWaltham, Massachusetts, United StatesDevelop a biocatalyst for generation of a natural product using a novel biosynthetic pathway.• Use strain and metabolic engineering to develop a bacterial chassis for improved product titres. Engineering strategies include construct design, chromosomal deletions and integrations, tuning of enzyme expression levels.• Optimise molecular biology workflows and biocatalyst fermentation conditions.• Responsible for implementation and execution of design-build-test-learn cycles of enzyme engineering.• Communicate results to colleagues in fast-paced collaborative environment. -
Postdoctoral ResearcherMassachusetts General Hospital May 2018 - Aug 2022Boston, Massachusetts, United StatesResearcher in the group of Professor Marcia Goldberg, investigating the pathogenesis of Shigella species, which are responsible for up to 165 million infections and 600 000 deaths annually worldwide.• Discovered the function of a virulence factor delivered during bacterial infection• Characterized a human innate immune complex protecting against bacterial infection• Determined modes of cell death in peripheral blood mononuclear cells of hospitalized COVID-19 patients and analyzed blood sample proteomes• Mentor of undergraduate and graduate students -
Postdoctoral ResearcherHarvard Medical School May 2018 - Aug 2022Boston, Massachusetts, United StatesAcademic appointment for postdoctoral position at Massachusetts General Hospital. -
Phd StudentImperial College London Oct 2014 - Jun 2018London, United KingdomWellcome Trust PhD program, group of Professor Alain Filloux• Characterized a secretion system virulence factor of the bacterium Pseudomonas aeruginosa, an important pathogen causing severe hospital-acquired infections. • Defined experimental conditions for demonstrating antibacterial activity of this type VI secretion system• Discovered that a structural component of secretion system in fact displays potent antibacterial activity• Determined mechanism of delivery of distinct repertoires of toxins• Identified several associated toxins delivered into target cells -
Summer Research InternNimr Jul 2012 - Sep 2012London, United KingdomStudentship position in the group of Dr Katrin Rittinger. I developed a high-throughput protein purification platform and initiated structural and biophysical characterization of human innate immune complexes. -
Visiting Research StudentCentre National De La Recherche Scientifique Sep 2011 - Jun 2012Toulouse, FranceResearch project as an Erasmus students at the Laboratoire de Microbiologie et Génétiques Moléculaires (LMGM), in the group of Dr Pierre Genevaux. Worked towards a purification method for a toxin-antitoxin-chaperone system. -
Summer Research StudentImperial College London Jul 2011 - Sep 2011London, United KingdomSummer studentship funded by the Biochemical Society, in the group of Dr James Murray. I carried out the purification of native macromolecular protein compexes from algae and undertook structural analyses.
Thomas Wood Skills
Thomas Wood Education Details
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Molecular And Cellular Basis Of Infection
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Distinction
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First
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Bootham School, YorkBiology (A), Chemistry (A), Maths (A), French (A), Latin As (A)
Frequently Asked Questions about Thomas Wood
What company does Thomas Wood work for?
Thomas Wood works for Manus
What is Thomas Wood's role at the current company?
Thomas Wood's current role is Scientist II.
What is Thomas Wood's email address?
Thomas Wood's email address is th****@****ard.edu
What schools did Thomas Wood attend?
Thomas Wood attended Imperial College London, Imperial College London, Imperial College London, Bootham School, York.
What are some of Thomas Wood's interests?
Thomas Wood has interest in Travel, Languages, Sport.
What skills is Thomas Wood known for?
Thomas Wood has skills like Private Sector, Sustainability, Climate Change, Finance.
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