Duc Phan Email & Phone Number

Cambridge, Massachusetts, United States

• Works with a senior scientist on an exploratory project to develop and optimize in vitro cell-based assays that can be translated into in vivo mouse studies
• Aseptic isolation, propagation, and cultivation of primary or established mammalian cell lines and tissue cultures
• Performance of analytical assays and complex multi-day cell-based functional assays (ELISA, qPCR, flow cytometry, Western Blotting) to support antibody characterization and/ or pharmacology studies
• Analysis, interpretation, and presentation of the results to all the relevant groups and team meetings
• Maintenance of detailed records of experimental protocols and data in the laboratory notebook in accordance with company policies

• Conducted an electrophysiology project on elucidating mechanisms of actions of Spec 36 specificity on Kir 3.1-containing subunit
• Performed TEVC to generate results to produce supporting data for the paper on a role of Spec 36 in the regulation of GIRK (Kir3) heterotetramers channels
• Executed site-directed mutagenesis tests to verify critical binding sites and elucidate the drug-ligand binding mechanisms of Spec 36 on homomeric and heteromeric GIRK channels
• Participated in weekly lab journal club meetings to discuss and analyze biomedical-related scientific papers to enhance the understanding of the pharmacology and pathophysiology of GPCR (G-protein-coupled receptors).
• Analyzed data with GraphPad Prism, Excel, and R programming to evaluate statistically the potency, efficacy, and specificity of Spec 36

• Conducted a project about overviewing drugs differentiate between homomeric& heteromeric subunits of GIRK (Kir3) channels
• Performed electrophysiology technique (TEVC – two-electrode-voltage clamp) to produce dose-response curves of IVM (Ivermectin), VU0529331, and Spec 59 and assess their selectivity for GIRK 2, GIRK 4, GIRK 1/2, and GIRK.
• Executed site-directed mutagenesis tests to verify critical binding sites and elucidated drug-receptor interaction mechanisms of VU05239931 and Spec 59 on GIRK 4
• Elucidated mechanisms of actions of small molecules that target GIRK (G protein-gated inwardly rectifying K+) channels as well as examine the dependence of GIRKs activity on phosphatidylinositol 4,5-bisphosphate (PIP2)
• Produced a scholarly work that puts a testable hypothesis, background, experimental data, results, and discussion into a literature context

Boston

• Worked closely with a research faculty (mentor) to be trained in electrophysiology method (two-electrode-voltage clamp – TEVC)
• Learned to do all other associated lab techniques to conduct TEVC experiment (DNA/RNA making with T7 Transcription Kit, gel electrophoresis, buffer preparation, cell isolations, oocyte injection)
• Performed TEVC to screen compounds (from drug library) to identify potent and efficacious small-novel molecules that can activate/ inhibit with complete specificity for GIRK (Kir3) channel
• Data analysis using GraphPad Prism, Excel and R program to assess statistically the potency, efficacy, and selectivity of new compounds
• Attended weekly personal meetings with Dr. Logothetis to gain insights into the laboratory research background with a focus on GIRK channels and their activity via the master regulator of membrane protein function.

Boston, Massachusetts, United States

• Served as an essential resource during the welcoming week for newly coming freshmen
• Hosted orientation week program and information session to aid newly enrolled undergraduate students and families to locate resources, programs, and platforms to chart their Northeastern path with global research, and.
• Assisted students in navigating and building networks within the Northeastern global community, and enhanced their “Husky” experience (both academic & social experiences)

Boston, Massachusetts, United States

• Responsible for providing access control at Northeastern University residence halls
• Maintained a quiet, well-lit, open space area and monitored surrounding activities to ensure a secure environment as well as reported any suspected irregularities to the supervisor
• Serve as the first contact for non-residents/ guests, on behalf of the university, by providing basic campus information, miscellanies/ trivia, and helpful resources

Woburn, Massachusetts, United States

• Planned and performed hands-on laboratory experiments using chromatographic analysis (HPLC) and UV-Vis spectrometer
• Conducted dissolution-testing experiment to assess the stability and efficiency of the drug
• Contributed and maintained detailed technical documentation (experimental plans, standard operating procedure, laboratory reports)
• Prepared buffers, and experimental chemicals (assays, organic solvents, mobile phase), and assisted other chemists as required

Ho Chi Minh City, Vietnam

• Consulted and helped about 20 patients daily understand the prescription and OTC drugs
• Learned more about commonly prescribed drugs on the market (e.g., cardiovascular agents, analgesics, and antidiabetic drugs)
• Monitored inventory daily selling drugs with low capacity and order replenishment in accordance with the pharmacy market’s plan
• Labeled and stocked medicine in storage within the Ministry of Health's compliance

Ho Chi Minh City, Vietnam

• Translated training materials related to company medicinal products, and pathologylectures from English to Vietnamese and vice versa; translated and proofread standardoperation procedures (SOPs) documents
• Organized, planned, and hosted product training sessions for the company pharmacists
• Attended, took notes, and learned about pharmacology of the drug from educationsession lectured by doctors, pharmacists, and scholars

Master Of Science - Ms, Pharmaceutic And Drug Delivery Systems, 3.8/4.0

Bachelor Of Science - Bs, Pharmaceutical Sciences, 3.6/ 4.0

High School Diploma