Duncan Hay Email & Phone Number

Oxfordshire, England, United Kingdom

Oxford, United Kingdom

Led a team of chemists working on preclinical drug discovery collaborations. Co-inventor on published and filed patent applications. Co-organised chemistry seminars and coordination of external sponsorship strategy. Participated in recruitment.

Oxford, United Kingdom

Discovered chemical probe for CBP/p300 bromodomain. Utilized structure-based drug design to optimize a weak and non-selective fragment into a potent, selective and cell-active probe compound. Synthesized ~200 test compounds in pursuit of probe also developed new skills in protein expression/purification and isothermal titration calorimetry.

Developed routes to challenging targets which helped projects to meet targets. Key part of a strategy group which aimed to highlight and solve solid form issues early on in the discovery process. Chaired Seminar Committee which organised symposia with invited academic speakers. Led a contractor chemistry team and supervised a placement student and project.

Synthesized monomers and designed protocols for larger library chemistry resulting in successful delivery of large numbers of new targets to various projects. Investigated hits from high-throughput screens to generate new lead matter for medicinal chemistry projects. Utilized parallel synthesis/purification, microwave chemistry and solid supported reagents

Dphil, Organic Chemistry

Design and synthesis of small molecule chemical probes for bromodomain-containing proteins under supervision of Prof. C. Schofield and.

Mchem, Chemistry, 1St Class Honours

Activities and Societies: Class Representative for Chemical Pharmacology, member of University Chemistry Society, participated in.