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I am a Ph.D. in Chemical Biology with over a decade of expertise in protein engineering for applications in cell biology and therapeutic development.My skill set encompasses directed evolution, library construction and screening, structure/sequence-based protein analysis, as well as the design and engineering of enzymes and protein sensors. I have proficiency in both in vitro and live-cell assays, along with a robust background in molecular biology, protein science, enzymology, and various biochemical and cell biology techniques. My professional journey includes a proven track record highlighted by multiple publications and patents in the fields of fluorescent biosensor engineering and assay development.As an effective communicator, I excel in presenting research findings and have experience teaching graduate-level courses. My leadership capabilities extend to successfully guiding research teams, managing laboratory operations, and fostering a collaborative, interdisciplinary approach. My overarching objective is to contribute my expertise in protein engineering towards advancing scientific discovery and addressing the needs of patients.
Basecamp Research
View- Website:
- basecamp-research.com
- Employees:
- 55
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Principal Scientist, Protein EngineeringBasecamp ResearchBoston, Ma, Us
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Senior ScientistResonance Medicine, Inc.Boston, Ma, Us -
Senior Scientist, Protein EngineeringFapon Feb 2024 - PresentDongguan, Guangdong, Cn -
Senior Scientist, Protein EngineeringResonance Medicine, Inc. Aug 2022 - Jan 2024Cambridge, Ma, Us- Evolved and characterized proteases for therapeutic targets using phage-assisted evolution platform. - Rationally designed and engineered protease constructs for improved expressibility and cleave activity.- Established and deployed fluorescence-based assays for characterization of protease activities.- Led new protease project, identifying, and characterizing developable human protease scaffolds. - Led guided protease project to enhance target binding and cleavage by binder-protease fusions. - Coordinated and aligned cross-functional teams (platform, biochemistry, protein production) for effective communication to meet project goals and timelines. - Managed and mentored 2 FTE (1 scientist & 1 research associate) as protein engineering team lead. -
Research ScientistUniversity Of Alberta Dec 2016 - Aug 2022Edmonton, Ab, Ca- Engineered fluorescent protein-based molecular tools for probing cellular dynamics.- Mentored 4 graduate students and 2 postdocs, supervising research projects. -
InstructorUniversity Of Alberta Sep 2018 - May 2022Edmonton, Ab, CaLectured CHEM 451/551 Chemical Biology & CHEM 405/519 Bioanalytical Chemistry.
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Research FellowHarvard Medical School Apr 2015 - Nov 2016Boston, Ma, Us- Developed fluorescence (FRET) and luminescence (NanoBit) assays for bacterial toxin activity detection.- Engineered bacterial protease toxin for improved affinity, thermostability, and enzymatic activity.- Supported the identification and characterization of novel bacterial toxins. -
Graduate Research And Teaching AssistantUniversity Of Alberta Sep 2009 - Mar 2015Edmonton, Ab, Ca- Engineered novel fluorescent protein and fluorescent protein-based biosensors- Developed in vitro and cell-based assays for screening fluorescent protein-based biosensors- Responsible for lab management including supplies, maintenance, training lab personnel - Instructed chemistry lab courses
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Quality ControlJiangsu Wuzhong Industrial Co., Ltd. Jan 2009 - Jun 2009Suzhou, Jng, Cn- Performed quality control tests of recombinant human granulocyte colony-stimulating factor (rhG-CSF) -
Undergraduate Research AssistantChina Pharmaceutical University Jul 2008 - Jan 2009Nanjing, Jiangsu, Cn- Expressed and characterized of recombinant human stellate cell activation-associated protein (rhSTAP)
Yi Shen Skills
Yi Shen Education Details
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University Of AlbertaChemistry -
China Pharmaceutical UniversityBiopharmaceutical Sciences
Frequently Asked Questions about Yi Shen
What company does Yi Shen work for?
Yi Shen works for Basecamp Research
What is Yi Shen's role at the current company?
Yi Shen's current role is Principal Scientist, Protein Engineering.
What is Yi Shen's email address?
Yi Shen's email address is ea****@****ail.com
What is Yi Shen's direct phone number?
Yi Shen's direct phone number is +178065*****
What schools did Yi Shen attend?
Yi Shen attended University Of Alberta, China Pharmaceutical University.
What are some of Yi Shen's interests?
Yi Shen has interest in Children, Camera Store, Musician/band, Video Creator, Mcbain Camera, Cafe, The Fray, Education, Science And Technology, Khalil Fong 方大同.
What skills is Yi Shen known for?
Yi Shen has skills like Analytical Chemistry, Protein Expression, Fluorescence Microscopy, Molecular Biology, Spectroscopy, Protein Chemistry, Molecular Evolution, Protein Engineering, Scientific Writing, Laboratory Management, Molecular Cloning, Cell Culture.
Who are Yi Shen's colleagues?
Yi Shen's colleagues are Raphael Chaleil, Jonathan (John) Finn, Silvano Ulivi, D'arcy Doran, Emma Bolton, Gavin Ayres, Matthew Bakalar.
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