DeltaG is the start, but there is lots more to think about. Understanding is the key.A reductionist approach to libraries makes many more things possible.

Available to exploit over 20 year's experience in academia and industry in a range of life sciences including antibody drug discovery, peptide drug discovery, CAR T, protein crystallography, biotransformations and protein engineering.

Miti Biosystems GmbH is developing libraries of polycyclic peptides called RiPPs. This special class of natural peptides resemble many antibiotics in use today, but the structures can be diversified into large libraries using phage display and specialised enzymes from nature which form constraining bonds. Miti's RiPP libraries represent the most highly constrained peptides known to date and offer a new alternative to more established constrained peptide companies such as Aileron, Ensemble, Ra, PeptiDream, Bicycle and LanthioPharm. The company has raised €1m to date. Web: www.mitibio.com

I, along with my team, developed a process for the selection, screening and sequencing of bicyclic peptides within a week. Low nM to pM peptides were often isolated directly from the libraries. One compound that I discovered has been out licensed and another has entered clinical trials http://pharmaphorum.com/news/bicycle-therapeutics-signs-deal-cancer-research-uk/

First structural determination of PI3K, leading to publications in Nature, Cell and Molecular Cell.

Protein engineering of morphine dehydrogenase for improved properties in the biotransformation of morphine.