Eric Hobson Email and Phone Number

Contributed to the design, integration, and optimization of an acoustic platform for high-throughput mammalian cell transfection.Optimized transfection efficiency and viability through biological and acoustic optimization• Standardized methods and analysis of biological assays used to assess system performance, including flow cytometry and fluorescent microscopy.• Identified key operational parameters during sonoporation that enabled increases in transfection efficiency and reproducibility with a variety of genetic payloads. • Devised analytical acoustic methods for real-time detection of sonoporation.Designed and tested new acoustic hardware for high-throughput applications• Developed hardware and software for automated and repeatable measurements of electrical and acoustic performance and applied these tools to assess prototype hardware configurations and applications. • Utilized signal processing and data science tools to generate insights and drive decision on system design.Communicated research findings to relevant stakeholders.• Generated multiple internal technical disclosures and contributed to a patent filing on a novel analytical method.• Shared research findings and technical progress with technical experts and senior company leadership.• Supported communication and collaborative research with external scientists and engineers.

Developed ultrasound techniques and built custom instrumentation for the non-invasive manipulation and characterization of fluids and soft viscoelastic materials, including tissue engineered constructs and soft tissues.Invented a novel ultrasound technique, Resonant Acoustic Rheology (RAR), for non-contact, high-throughput viscoelastic measurements of soft biomaterials• Designed and built prototype system integrating a mixture of commercially available and custom electrical and mechanical components necessary for signal generation/detection, 3-D motion control, fluidics, temperature control, etc.• Created software tools for fully automated testing in a variety of usage modes while utilizing real-time sensor feedback for tasks such as alignment or anomaly detection.• Developed comprehensive software package for analysis to process raw sensor data, incorporating mechanistic and computational models of resonant surface waves, to accurately calculate intrinsic viscoelastic material properties.Developed computational tools to improve the diagnostic efficacy of ultrasound imaging.• Built novel image processing toolbox to enable clinical collaborators to view and process 3-D spectral ultrasound from a simple GUI.• Utilized this tool to detect early stages of mineralization in mouse and rat models of Heterotypic Ossification (HO)• Implemented machine learning algorithms to aid in discrimination between vasculogenic and osteogenic differentiation in tissue engineered constructs.Applied high-throughput experimental and computational tools, including bi-linear modeling and hierarchical clustering, to provide systems level analysis of biological questions.• Detected conserved regulatory pathways in the development of drug-resistance in BRCA mutant cancers using dynamic transcription factor activity measurements.• Adapted a method for the spatially controlled patterning and transduction of mammalian cells using an aqueous biphasic system

I help students in an introductory engineering programming class.