● Investigated solid state properties, salt forms, and polymorphic behavior of active pharmaceuticalingredients (API) in various stages of pharmaceutical development, and authored many technical reports for client partners.● Performed polymorph, salt and co-crystal screening projects with client API compounds.● Solved many process-related problems for SSPI’s client partners, scaling up production for polymorphic form and particle specificity, improving yields, process efficiency, handling conditions, and minimization of batch impurities.● Participated in several workflow development initiatives and internal research projects.● Routine use of X-ray Powder Diffraction (XRPD), Differential Scanning Calorimetry (DSC), Thermogravimetric Analysis (TGA), Gas Chromatography (GC), Dynamic Vapor Sorption (DVS), Karl Fischer titration (KF), microscopy and particle size analysis.● Routine use of Agilent 1100 series high-performance liquid chromatography systems for method validation and development, and purity assessment of materials.● Routine use of spectroscopic analytical instrumentation: Nuclear Magnetic Resonance spectroscopy (NMR), spectrophotometer (UV-Vis), Fourier-Transform Infrared spectrometer (FTIR).● Utilized Mettler Toledo’s process analytical tools such as Focused Beam Reflectance Measurement(FBRM) with Particle Track, Particle View, ReactIR for monitoring large scale crystallization experiments.● Sourced, validated, maintained, calibrated, and repaired all analytical and process development-related instrumentation.● Ensured the company met all goals and milestones as part of the team that implemented the Quality Management System and obtained ISO-9001 accreditation.● Coordinated activities in designing a workspace and relocating the company to a new, customized facility in downtown Halifax.● Acted as head of the Occupational Health and Safety Committee, organizing all meetings, inspections, and coordinating follow up on all action items.

● Synthesized thousands of molecules in parallel for hit-to-lead efforts in medicinal chemistry programs.● Collaborated with FORMA’s teams, academic, and external partners in designing chemical libraries for a unique high-throughput screening platform utilizing mixture-based, DNA-encoded libraries.● Designed and performed experiments to validate reaction conditions for introduction to a production environment.● Acquired and operated Tecan robotic instruments with EvoWare software for thousands of chemical solution transfers.● Introduced BioMicrolab’s XL100 automated weigh station to acquire vial tare and gross weights for purified fractions and for cherry-picking barcoded vials.● Verified and informatically tagged the stereochemistry of materials received from synthesis partners.● Analysis of compounds by LCMS with ThermoScientific mass spectrometers and Waters’ high-performance liquid chromatography (HPLC) systems, including Empower chromatography software.● Used Core Informatics’ Platform for Science for workflow management, Cambridgesoft’s Electronic Lab Notebook, Coupa purchasing application, and SciFinder for seeking out scientific literature.● Worked with third-party engineering firms to design custom lab facilities and instrumentation.

● Acted as lab manager for Lead Discovery group’s hit follow-up library synthesis lab.● Synthesized thousands of molecules in parallel, for hit-to-lead efforts in medicinal chemistry programs.● Ensured lab members were in compliance with Merck’s safety policies and that our lab met company standards for cleanliness and organization (5S methods).● Trained new lab members on a variety of the methods and tools of molecular library synthesis and completely rewrote all synthesis Standard Operating Procedures for clarity and uniformity.● Acquired and operated Hamilton STAR robotic instruments and software for thousands of chemical solution transfers.● Collaborated with Merck and Hamilton engineers in designing a workflow to utilize MRL Boston’spurification group for library purification, including designing necessary software updates, andemploying a Pipeline Pilot interface.● Successfully set up and ran a quality control line for confirming synthesized compounds by mass with Thermo Exactive Orbitrap mass spectrometer and Agilent 1200 series HPLC components using Xcalibur software, including maintenance of analytical instrumentation.● Performed a variety of NMR experiments with Varian instrumentation including analysis with vNMRj software suite.● Used Merck’s web-based ordering/tracking system, Cambridgesoft’s Electronic Lab Notebook, and SciFinder for seeking out scientific literature.

● Synthesized discrete compounds and mixture-based libraries for screening in the Automated Ligand Identification System (ALIS), a mixture-based screening technology for pharmaceutical discovery.● Synthesized thousands of molecules with the Mettler-Toledo MiniBlock parallel synthesis equipment for hit-to-lead efforts in a variety of medicinal chemistry programs.● Utilized the Tecan Genesis robotics platform and Gemini software for liquid handling in compoundsynthesis, aliquoting, dilution, screening, testing, and confirmation of thousands of samples.● Worked with automation and database engineers to develop tools to improve workflow with the Tecan platform, increasing the amount of automated synthetic liquid handling processes at the company, and performed analytical experiments to validate methods and technology.● Enhanced data handling and instrument deck layouts for automated synthesis, including rack, vial, and MiniBlock relationships.● Synthesized scaffold/core and building block materials for project related activities.● Analyzed chemical data with Chemstation, Masslynx and Chemdraw programs; set up NMR experiments and analyzed data with NUTS NMR program.● Adhered to a strict notebook and document protection policy.● Attended safety training meetings and participated in the lab safety committee.

● Synthesized thousands of molecules for process and mass confirmation using Cavro liquid handlingrobots with RSP Integrator program for the company’s collaborations with external partners.● Assisted with experiments in the development of solution phase and solid phase synthesis processes.● Operated Tecan Genesis robots for sample preparation in support of compound screening with the Automated Ligand Identification System (ALIS).● Designed and programmed robotics systems for Tecan Genesis instruments with Gemini software, and for Cavro robotics systems with RSP Integrator program.● Programmed and operated Mettler-Toledo Balance Automator weighing system for acquisition of product yields.● Used CisPro and ISIS software for inventory management of reagents, product libraries, synthetic cores, and building blocks.● Ordered and received stocks of lab supplies and reagents for the chemistry department.● Maintained synthesis-oriented equipment and facilities.