My research uses single-nucleus and spatial transcriptomics to map the gene expression landscape of the human brain. I develop reproducible analysis pipelines to integrate large-scale omics datasets across species and data modalities, leveraging cutting-edge machine learning methods to identify both functionally relevant gene expression signatures and potential therapeutic targets.
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Principal ScientistGskPhiladelphia, Pa, Us -
Computational Biologist - Translational OmicsGsk Dec 2024 - Present -
Graduate Student ResearcherLieber Institute For Brain Development Aug 2019 - Jul 2024Washington Dc-Baltimore Area• Built a comprehensive molecular map of the human hippocampus using spatial transcriptomics and single-nucleus RNA-seq• Designed and implemented advanced machine learning pipelines to automate discovery of cell types and tissue cytoarchitecture• Integrated cross-species epigenomic and viral circuit tracing data using transfer learning to predict human neuron connectivity• Leveraged nonnegative matrix factorization (NMF) to uncover neuron cell states and activity-regulated gene expression signatures• Processed GWAS data and integrated with transcriptomic atlas to identify cell types and cell states vulnerable in disease• Developed scalable computational pipelines for genomics data analyses to facilitate reproducibility and accessibility -
Technical Research AssociateMassachusetts Institute Of Technology (Mit) May 2016 - Jul 2019Greater Boston Area• Pioneered a high-throughput, automated confocal microscopy pipeline to rapidly scale high-quality image acquisition• Designed and optimized immunofluorescence assays to characterize pathology in mouse models of stress and Huntington’s• Collaborated with software engineers to build and implement an automated computational microscope image analysis pipeline• Contributed to 2 high-impact publications through significant experimental and computational efforts -
Honors Research FellowWilliam & Mary Apr 2015 - May 2016Dublin, IrelandWith an interdisciplinary approach, I explored the formation, development, and alteration of collective memory within social groups by combining principles from neuroscience, psychology, and sociology. -
Undergraduate Research AssistantWilliam & Mary Sep 2013 - May 2016I conducted rodent behavioral assays to examine the role of the basal forebrain cholinergic system in attention and impulsivity. I collected and analyzed data and assisted with rat surgeries. -
Summer Research FellowCincinnati Children'S Hospital Medical Center May 2014 - Aug 2014I studied hippocampal dentate granule cell neurogenesis and development in the context of epilepsy. I characterized a novel transgenic mouse model and created 3D reconstructions of hippocampal neurons to analyze morphological changes. I performed mouse breeding and other colony maintenance tasks.
Erik Nelson Education Details
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Cellular And Molecular Medicine -
Neuroscience And English
Frequently Asked Questions about Erik Nelson
What company does Erik Nelson work for?
Erik Nelson works for Gsk
What is Erik Nelson's role at the current company?
Erik Nelson's current role is Principal Scientist.
What schools did Erik Nelson attend?
Erik Nelson attended The Johns Hopkins University School Of Medicine, William & Mary.
Who are Erik Nelson's colleagues?
Erik Nelson's colleagues are Arpit Dixit.
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Erik Nelson
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Erik Nelson
Washington, Dc
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