Research Projects: Dissecting stromal evolutionary routes in primary versus metastatic microenvironmentsLaboratory of Prof. Dr. Mara H. Sherman

Research Projects: Understanding tumor initiation and drug-induced tumor evolution of the tumor microenvironment in pancreatic cancerLaboratory of Prof. Dr. Alexander Kleger

PhD Thesis Project: Molecular characterization of putative targets in pancreatic tissue regeneration and cancer homeostasisPrimary Investigator: Prof. Dr. Alexander Kleger

Master Thesis Project: Novel mechanistic insights in the tetraspanin CD37 in human B-cells by single point mutationPrimary Investigator: Dr. Sjoerd van Deventer

Department of protein biochemistry / cellular microbiologyResearch Project: Streptococcus pneumoniae pilus adhesin RrgA interacts with integrins α5β1 – an additional puzzle for successful host interaction?

Department of SurgeryBachelor Thesis Project: “Identification of predictive biomarkers and markers of therapeutic resistance in primary ovarian cancer.“ Main activities: • Genotyping of tumor cells using qPCR • Phenotyping of tumor cells using immunohistochemistry (IHC) • Immunoscoring of CD45, CD3 and CD8 using IHC • Working with patient-derived material and commercial available tumor cell lines

Department of SurgeryResearch Project: Establishment of biomarkers for detection of tumor-infiltrating lymphocytes and PD-L1 in primary ovarian cancer. Main activities: • Preparation and cryopreservation of human tissue • IHC staining of frozen sections • Microscopical evaluation of IHC-stained normal and cancer tissue • Documentation according to DIN EN ISO 9001

Main activities: • GMP- dependent production of human blood sera/ -plasma, immunoreagents and diverse proteins in laboratory and technical scale• Writing and revision of standard operation procedures • Optimization of e.g. scale-up processes • Characterization of products using analytical methods (e.g. HPLC) • Documentation according DIN ISO and GMP • Handling with plant, animal and human material