George Mayhew Email & Phone Number

Madison, Wisconsin, United States

Argyle, Wisconsin, United States

• Consulting services for bioinformatics, laboratory sequencing automation, and genetic data science, specializing in data-driven discovery in microbiology, biologics, cancer genomics, and agricultural science.• Perform sequence analysis using portable cloud-based containers, infrastructure, and tools.• Provide recommendations for sequencing projects and planning for data analysis pipelines.• Build and assist in deployment of custom sequence analysis pipelines for customers.• Provide custom data and process modeling and system configuration templates for sample-tracking and LIMS.

Madison, Wisconsin, United States

• Managed team of bioinformaticians; oversaw all informatics projects related to R&D, Operations, and Business Development functions. • Lead and project owner for deployment of Benchling (SaaS LIMS) across the entire organization, servicing 100 accounts. Directed teams for process mapping, building out data models, creating ERDs, and building out schemas and workflows. Built and maintained relationships with Benchling internal teams to expedite new features to our scientists. Reshaped entire organization’s data strategy in under eight months.• Lead organization towards complete end-to-end data integration, starting with experimental designs, through data acquisition and sample tracking, and ultimately to data summary and reports.• Built out an internal support infrastructure for Benchling that included the entire Bioinformatics team as well as contributions from volunteer scientists from each function group, consisting of up to twenty people.• Designed a change review process for the company, initially to support change management of the Benchling system. Deployed that process and oversaw change requests. Assigned priorities and resources in support of the System.• Administered three Benchling tenants for development, testing and training, and production environments. • Deployed an ITSM and ticket tracking system to manage requests to Bioinformatics. Worked with PMO and other development staff to move the system to Atlassian and establish guidelines for agile development practices across the organization.• Supervised API development for Benchling and PipeBio systems; building tools to enter and retrieve data from both and integrate these systems into a single workflow in the laboratory.• Built out pipelines and tools to support Sanger, Illumina, and nanopore sequencing, with an emphasis on antibody assembly and annotation.• Lead team of scientists investigating machine learning methods for antibody discovery.

Waunakee, Wisconsin, United States

• Senior scientist role in designing and analyzing experiments using RNA-Seq, scRNA-Seq, and WGS. Executed analysis and built reports to be included in internal and customer-facing documentation.• Developed pipelines for the above sequencing methods on test and production clusters using various tools and managing executions via Slurm.• Built out pipelines to support analysis of 10x Genomics scRNA-Seq data; trained other informaticists in use of these tools.• Advised Global IT/Data Science on infrastructure needed to support sequencing for NovaSeq data.• Participated in a team constructing pipelines for deep sequencing of complete cattle genomes.• Participated on a team improving on tools to annotate cattle genomes and track their variants across multiple lineages.• Participated on a team deploying a Snowflake data lake to cache genomic and expression data from public and private repositories for timely retrieval and viewing in an annotation workbench.• Built out methods of analyses of expression data for pathway analysis using Qiagen’s Ingenuity Pathway Analysis Workbench. Trained bench scientists in the use of the tools to explore their data sets after analysis.• Maintained an installation of CLC Bio for general use across the company. Became proficient in the tools and trained other informaticists and bench scientists in their use.

Madison, Wisconsin, United States

• Technical and project lead for several target enrichment diagnostic panels intended for the Laboratory Developed Test (LDT) market.• Developed panels, prepare testing parameters, and work with laboratory leads on test execution following approved corporate and local product development pipelines. • Coordinate with global research, marketing, and sales teams on developing differentiated products and proper product positioning for the target market.• Manage key metrics, track project status, proactively identify risks, issues and mitigation plans, and report status in team meetings and to senior leadership.• Lead global data governance project, defining data types/storage environment for multiple workgroups.• Identify and define new product ideas or technologies, conduct feasibility, optimization, verification and validation studies, perform method and product transfer to manufacturing and support of regulatory submissions within the context of ISO 9001 and 13485 quality systems.• Co-authored several customer-facing technical documents and developed analysis pipelines in support of product development.• Interfaced with cross-functional teams to improve technical processes by taking an end-to-end perspective with a focus on improved quality and increased stakeholder satisfaction.• Designed custom target enrichment experiments in coordination with customers; provided detailed sequence analysis and reports.• Provided bioinformatics support to Customer Support, Complaint Resolution, and Quality on product portfolio.• Mentor and coach junior researchers through a “lunch and learn” series, providing technical guidance to improve their subject matter expertise and individual performance in areas such as machine learning, artificial intelligence (AI), natural language processing, and large genomic data processing.• Served as local team member for division-wide culture initiative that drove cooperating-centric values into the global corporate structure.

Madison, Wisconsin, United States

• Provided custom Sequence Capture designs for Roche Nimblegen customers and used Standard Operating Procedures (SOPs) to create custom probe designs for human and non-human capture experiments. • Strategized, developed, and executed new bioinformatics tools to help laboratory scientists.• Collaborated with leadership and other team members to structure the bioinformatics tool/pipeline development process to improve the efficiency of the bioinformatics team.• Managed change orders, participated in design control process for new product release, and update/maintain SOPs as product specifications change.• Interfaced with cross-functional teams and customers during the design process to identify technical requirements and address potential technical risks.• Stayed current on scientific developments and assessed new technology/new product process capabilities. • Liaison with Nimbledesign web portal developers and updated/maintained scripts for production support following computer systems validation guidelines.• Mentored and coached junior bioinformatics scientists and provided technical training for scientific and operational staff members.

• Led complex projects, oversaw multi-disciplined teams and subject matter experts to conduct experiments within several technology and research areas.• Performed biostatistical, computational, and laboratory studies of global expression profiling of parasite-host interactomes using RNA-Seq and hybridization arrays. • Managed the laboratory, designed and printed customer arrays, supported the grant writing/ submission process, performed experimental design consultation, budget inputs, and regulatory protocol submission.• Prepared reports and documentation providing an analysis or summarization of project status/results.• Planned, designed, and executed technical studies that met laboratory objectives and goals.• Presented findings at scientific meetings and published multiple research papers. • Oversaw computer support for research lab and instructional staff and trained graduate researchers in the methods of discovery using high- throughput techniques.

• Automation and technology development team leader at UW-Madison's Genome Sequencing Laboratory. Evaluate, implement, and supervise all automation hardware and software in a high-throughput genome-sequencing laboratory. Planned, tested, implemented new procedures to improve throughput and automate workflows for sample processing and management. Tech transferred procedures to operational teams and trained staff in procedures. Maintained SOPs for use by operational staff.• Technical advisor/bioinformaticist for the Genome Center of Wisconsin Genome Sequencing Facility.• Supervised R&D of engineering, biochemical, and microbiological processes for use in the high-throughput sequencing production line. • Integrated automation hardware and LIMS. Sequencing and comparison of enteric bacterial pathogens; contract sequencing for several UW investigators.• Built, deployed, and maintained LIMS for use with high-throughput fluorescent sequencers and robots • Trained staff on use of new systems. • Engineered, programmed, and maintained liquid/sample-handling automation platforms for the laboratory.• Collected specifications for systems, built out requirements, and followed through with vendors for equipment and software.• Built visualizations to track performance of equipment and laboratory staff to focus on optimizing efficiency. • Worked with software development teams to build analysis pipelines for data, both for quality monitoring and end-stream data analysis.• Re-engineered some components of our sequencers to increase accuracy of base calls and increase sample through rates.• Participated in grant-writing.• Published findings and presented data at international meetings.

Frederick, Md

• Design and perform a wide variety of experiments in immunology, microbiology, and molecular and cellular biology.• Purify toxins from various recombinant and native strains of Staphylococcus.• Maintain animals necessary for experiments.• Design experiments using laboratory animals.• Maintain all laboratory equipment and track supplies.• Laboratory radiation specialist.• Train and supervise new laboratory personnel.• Perform computational analysis of various staphylococcus genes and gene constructs.• Perform experiments in P-1, BL-2, and BL-3 containment suites as well as “clean” suites and gnotobiotic animal labs.

Masters Of Science, Microbiology

Activities and Societies: American Society for MicrobiologyResearch project on the genetic nature of Anthrax toxin at USAMRIID, Ft. Detrick.

Bachelor Of Arts, Biology/Chemistry/Genetics

Activities and Societies: American Chemical Society, American Society for Microbiology, Alpha Psi Omega Honor Society - President

Associate Of Arts, Biology/Chemistry