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Hannah Doss is a Graduate Research Assistant at Rensselaer Polytechnic Institute. She possess expertise in process development analytics, downstream process development, monoclonal antibody purification, lean six sigma, design of experiments and 22 more skills. Colleagues describe her as "Hannah had worked with me at BMS Devens for the past one year. She was highly detail oriented and did an excellent job accomplishing a few continuous lab improvement projects. During the process, she elicited cooperation from others and demonstrated a skill to work with different personalities. Besides the lab improvement projects, Hannah had been acting as an MS&T lead in supporting the external manufacturing of a best selling biologic drug in the immunology therapeutic area. She… Show more"
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Graduate Research AssistantRensselaer Polytechnic InstituteTroy, Ny, Us
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Graduate Research AssistantRensselaer Polytechnic Institute Aug 2018 - PresentTroy, New York, United States
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Associate Engineer I - Downstream Manufacturing Sciences And TechnologyBristol-Myers Squibb Apr 2017 - Aug 2018Devens, MassachusettsServed as Matrix-Lead/MST Downstream point of contact for two simultaneous commercial manufacturing campaigns (internal and third-party manufacturing). Responsible for providing MST downstream support of process deviations/investigations/CAPA’s/change controls/ filing revisions. Successfully lead end-to-end UF/DF process characterization in support of a CBE-30 filing revision. Lead process characterization projects for fc fusion proteins regarding aggregate modulation across hydrophobic interaction chromatography.Lead aggregate characterization studies of fc fusion proteins to determine bioactivity discrepancies between monomer and aggregate species. Data used to finalize DS aggregate IPC acceptance criteria. Supported chromatography and viral filtration viral clearance studies for fc fusion proteins. -
Associate Scientist 1 - Downstream Process DevelopmentBristol-Myers Squibb Jun 2015 - Apr 2017Devens, MaLead and supported intensive development and characterization for the downstream processes of numerous late-stage clinical molecules (monoclonal antibodies/Fc fusion proteins) utilizing the following chromatography/filtration methods and analytical assays: Protein A Affinity/Viral Inactivation, CEX, AEX, HIC,Depth Filtration, UF/DF, HPLC/UPLC, Caliper (high throughput SDS-PAGE), iCIEF (imaged capillary isoelectric focusing), Tecan high throughput purification.Lead projects for the following: Viral Clearance Studies, Cumulative Hold Time Stability Studies, CEX/AEX Screening DOE's, AEX/Viral Inactivation process development, Intensive molecular aggregate characterization Supported scale-up runs to support Tech Transfer to Clinical Manufacturing.Utilized equipment and software: AKTA Avant 25/150, AKTA Pilot, DropSense96, LabChip GX II Touch, Tecan, Unicorn (versions 5.5, 6.0, 7.0), Empower 3.0, EvoWare, JMP.***Lean Six Sigma Yellow Belt Certified!
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Pilot Plant Fermentation (Process Development) Co-OpCubist Pharmaceuticals Jul 2014 - Dec 2014Lexington, MassachusettsPrepared bioreactors (1L, 20L, 100L), supplemental equipment, media, and other batch feed materials. Ran and monitored pilot-scale fermentations, harvested fermentation batches for purification, performed qualified SIP and CIP procedures, and ran and monitored scaled-down purification. Fermentations were monitored via daily sampling (Sterility, pH, Packed Cell Volume, concentration of essential ions and carbon sources, and product titer). Other Responsibilities: - Tested and presented a scaled down model of an optimized Tangential Flow Filtration system. - Executed comparability studies between raw material media components of two different manufacturers via scale down models. - Determined feasibility of using NIR as a replacement process analytical technology for HPLC. - Assisted in Cell Bank Autoclave Validation. - Prepared experimental protocol for extraction of a biopolymer from potato skins for utilization in production of natural products via organic extraction.Equipment, techniques, and software utilized: DeltaV, glass and stainless steel bioreactors, batch-fed fermentation, TFF, aseptic technique, buffer and media preparation, HPLC/UPLC, titer approximation, Nova Bioprofile analyzer, NIR, PAT -
Network Manufacturing Sciences And Technology Co-OpGenzyme May 2013 - Aug 2013Framingham, MassachusettsIndependently designed and performed experiments to compare settling behaviors of two types of microcarriers. Experimentation included time-based settling analysis, initial suspension sampling (obtain positional microcarrier concentration profile in 3D printed 70L "reactor"), minimum required agitation analysis for proper microcarrier suspension, Harvest (Batch) Re-feed Simulation (to determine the percent loss of valuable material lost during a harvest re-feed). Other supporting responsibilities: - Assisted in data analysis of harvest cone oscillations. - Participated in the early stages of the scale-up process of commercial product. -
Bioprocess Engineering CoopGenzyme Jul 2012 - Dec 2012Framingham, MassachusettsIndependently ran a study on heat transfer through different types of vessels, testing done to find vessel-specific heat transfer coefficient. Information needed to prevent disposing of useable product after a warm/cold room temperature deviation: wrote experimental protocol and technical report, ordered experimental equipment, ran studies, constructed MATLAB code to analyze and interpret data, worked with data logging equipment, thermocouples, and temperature-mediated rooms. Study results and conclusions used in current situations in the company.
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Center For Excellence In The Neurosciences InternUniversity Of New England Jun 2011 - Aug 2011Biddeford, MeAssisted in "in vivo" studies (mice) to determine functionality of opiate antagonist drug. Drug was used against Morphine (opiate agonist) and compared to Naloxone (opiate antagonist). Studies conducted:- Tail-flick Assay: measures antinociception. - Locomotor Analysis: shows how drug affects physical activity.- Dependence Studies (Acute and Chronic): Allows observance of withdrawal symptoms.- Gastrointestinal Transit: measures how drug increases/decreases rate of digestion.Met with various business CEO's from around southern Maine and learned fundamental entrepeneurship skills.Presented work to other interns, UNE professors, small Maine business associates and CEO's at the end of the employment period.
Hannah Doss Skills
Hannah Doss Education Details
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Chemical And Biological Engineering
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B.S. Chemical Engineering -
B.S. Chemical Engineering
Frequently Asked Questions about Hannah Doss
What company does Hannah Doss work for?
Hannah Doss works for Rensselaer Polytechnic Institute
What is Hannah Doss's role at the current company?
Hannah Doss's current role is Graduate Research Assistant.
What is Hannah Doss's email address?
Hannah Doss's email address is ha****@****bms.com
What is Hannah Doss's direct phone number?
Hannah Doss's direct phone number is +120721*****
What schools did Hannah Doss attend?
Hannah Doss attended Rensselaer Polytechnic Institute, Northeastern University, The University Of Edinburgh.
What skills is Hannah Doss known for?
Hannah Doss has skills like Process Development Analytics, Downstream Process Development, Monoclonal Antibody Purification, Lean Six Sigma, Design Of Experiments, Purification, Fermentation Process Development, Protein Purification, Affinity Chromatography, Ion Exchange Chromatography, Cell Culture, Tangential Flow Filtration.
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1virginiamason.org -
Hannah Rae Doss
Greenville, Sc2 +177078XXXXX
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