Hans Brightbill Email & Phone Number

Thousand Oaks, Ca, Us

South San Francisco, California, Us

South San Francisco, California, Us

Publications:Sun. T., Huang, Z., Liang, W.C., Yin, J., Lin, W.Y., Wu, J., Vernes, J.M., Lutman, J., Caplazi, P., Jeet, S., Wong, T., Wong, M., DePianto, D.J., Morshead, K.B., Sun, K.H., Modrusan, Z., Vander Heiden, J.A., Abbas, A.R., Zhang, H., Xu, M., N'Diaye, E.N., Roose-Girma, M., Wolters, P.J., Yadav, R., Sukumaran, S., Ghilardi, N., Corpuz, R., Emson, C., Meng, Y.G., Ramalingam, T.R., Lupardus, P., Brightbill, H.D., Seshasayee, D., Wu, Y., Arron, J.R. (2021) TGFβ2 and TGFβ3 isoforms drive fibrotic disease pathogenesis. Sci. Transl. Med. 13(605):eabe0407. doi: 10.1126/scitranslmed.abe0407.Gu, M., Zhou, X. , Sohn, J.H., Zhu, L-L. , Jie, Z., Yang, J-Y. , Zheng, X., Xie, X., Yang, J., Shi, Y., Brightbill, H., Kim, J.B., Wang, J., Cheng, X., S-C. Sun. (2021) NF-kB inducing kinase maintains T cell metabolic fitness in antitumor immunity. Nat Immunol. 22:530. doi: 10.1038/s41590-021-00892-7.Presentations:Anti-Fibrotic Drug Development Conference (AFDD) 2020. “A Comparison of CDA-HFD & High Cholesterol Diet Induced NASH Models Using Automated Quantitative Image Analysis and Deuterated Hydroxyproline Mass Spectrometry”. November 2020. Virtual Conference.IPF Summit 2020. Panel discussion: Preclinical Fibrosis Models. August 2020.

South San Francisco, California, Us

South San Francisco, California, Us

Awards:2019 Research Biology Recognition AwardPublications:Corzo C., U., et al. The kinase IRAK4 promotes endosomal TLR and immune complex signaling in B cells and plasmacytoid dendritic cells. Science Signaling 13:eaaz1053. Doi:10.1126/scisignal.aaz1053 (2020).Rajapaksa, N.S., et al. Discovery of Potent Benzolactam IRAK4 Inhibitors with Robust in Vivo Activity. ACS Med Chem Lett. 11:327-333. doi: 10.1021/acsmedchemlett.9b00380 (2019).Sun T, et al. (2019) TAZ is required for lung alveolar epithelial cell differentiation after injury. JCI Insight. pii:128674. doi: 10.1172/jci.insight.128674.Bryan MC, Drobnick J, Gobbi A, Kolesnikov A, Chen Y, Rajapaksa N, Ndubaku C, Feng J, Chang W, Francis R, Yu C, Choo EF, DeMent K, Ran Y, An L, Emson C, Huang Z, Sujatha-Bhaskar S, Brightbill H, DiPasquale A, Maher J, Wai J, McKenzie BS, Lupardus PJ, Zarrin AA, Kiefer JR. (2019) Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors. J Med Chem. doi:10.1021/acs.jmedchem.9b00439.Jie Z, et al. (2018) NIK signaling axis regulates dendritic cell function in intestinal immunity and homeostasis. Nat Immunol. 19:1224-1235. doi: 10.1038/s41590-018-0206-z. Epub 2018 Sep 24.Blaquiere N, et al. (2018) A scaffold-hopping approach to discover potent, selective and efficacious inhibitors of NF-κB inducing kinase. J. Med. Chem. doin:10.1021/acs.jmedchem.8b00678.Presentations:H.D. Brightbill. “Looking at the kinetics of transcriptional and extracellular matrix responses to Bleomycin induced lung fibrosis”. IPF Summit 2019, San Diego, CA.

South San Francisco, California, Us

Biology Lead for NIK small molecule program.Publications:Brightbill HD, et al. (2017) NF-kB inducing kinase is a therapeutic target for systemic lupus erythematosus. Nature Communications 9:179.Castanedo GM, et al. (2017) Structure-Based Design of Tricyclic NF-κB Inducing Kinase (NIK) Inhibitors That Have High Selectivity over Phosphoinositide-3-kinase (PI3K). J Med Chem. 60:627-640.Li Y, Wang H, et al. (2016) Cell intrinsic role of NF-κB-inducing kinase in regulating T cell mediated immune and autoimmune responses. Scientific Reports 6:22115.Katakam AK, Brightbill H, et al. (2015) Dendritic cells require NIK for CD40-dependent cross-priming of CD8+ T cells. Proc Natl Acad Sci U S A 112:14664-9. Presentations:American Association of Immunologists Conference 2017. Talk and poster, “Selective inhibition of NF-kappaB inducing kinase reduces disease and inflammation in IFNa-accelerated lupus nephritis prone mice.”Keystone Conference 2017, Immune regulation in Autoimmunity and Cancer. Poster, “Selective inhibition of NF-kappaB inducing kinase reduces disease and inflammation in IFNa-accelerated lupus nephritis prone mice.”Cytokine 2016 Conference. Poster, “Selective inhibition of NF-kappaB inducing kinase reduces disease and inflammation in IFNa-accelerated lupus nephritis prone mice.”LEADERSHIP:Summer Intern Mentor, 2017

South San Francisco, California, Us

R&D. Basic research and therapeutics for the treatment of allergy, asthma, and autoimmune disease.THERAPEUTIC PROJECTS:Quilizumab, anti-M1'​-IgE. Late stage, Early Development, IND Filing. 2007, 2009.Small Molecule therapeutic. Late stage transition, 2014.PRESENTATIONS:Keystone Symposium: The NF-κB System in Health and Disease, Keystone, CO, 2014. Poster: Conditional deletion of NF-κB Inducing Kinase (NIK) in adult mice disrupts mature B cell homeostasis and survival.AAI. Honolulu, 2013. Poster presentation entitled "Development of a Conditional NIK knockout Mouse".FOCIS Meeting. San Francisco, 2009. Oral presentation entitled “Therapeutic anti-human membrane IgE antibodies reduce serum IgE and deplete IgE producing cells in vivo” in session entitled “IgE”.Keystone Symposium: Allergy and Asthma. Keystone, C.O. Poster Presentation. January, 2009LEADERSHIP:Summer Intern Mentor, 2011 and 2014Research Trouble Shooters Committee, 2008-2014Department Representative, Radiation Safety Committee, 2015

Berkeley, Ca, Us

Research on the role of c-Abl in early B cell development and survival. 2004-2005: National Institutes of Health Fellowship, #CA09179-29.

Berkeley, Ca, Us

AWARDS:2001-2004. Leukemia and Lymphoma Society Fellowship #5325-02.

Los Angeles, Ca, Us

Research on cytokine gene regulation and the innate immune response to microbial lipid antigens through Toll-like Receptors.

Los Angeles, Ca, Us

Teaching assistant for undergraduate courses in Immunology and Molecular Biology.

Irvine, Ca, Us

PUBLICATIONS:Burger, R.A., et al. (1994) Host-tumor interaction in ovarian cancer. Spontaneous release of Tumor Necrosis Factor and Interluekin-1 inhibitors by purified cell populations form human ovarian carcinoma in vitro. Gynecol. Oncol. 55:294 – 303.Abe, Y., M. et al. (1993) The role of lymphotoxin in the IL-2-driven differentiation of human lymphokine-activated T-killer (T-LAK) cell in vitro. Lymphokine Cytokine Res. 12:279-283.

Ph.D., Microbiology And Immunology

B.S. Biological Sciences, B.M. Cello Performance, Biological Sciences, Music

Education record