Hoi-Ting Wu Q. Email & Phone Number

Thousand Oaks, Ca, Us

San Mateo, California, Us

San Mateo, California, Us

• Developed a 24-minute targeted MS method using 6495D TQ and Evosep to quantify 802 peptides in human plasma for cancer biomarker discovery. • Led and developed untargeted and targeted MS methods on several MS platforms, ensuring accurate and reproducible results in identifying and quantifying cancer biomarkers in human plasma samples.• Established and implemented robust, rigorous quality control (QC) measures to monitor LC-MS performance and ensure data integrity and instrument reliability.• Followed FDA guidelines to document test protocols and test reports for regulatory filing.• Trained and guided junior staff members on project workflows to increase team productivity.• Collaborated with cross-functional teams and provided technical support on proteomics experiments for assay and platform development.

Riverside, Ca, Us

• Developed a novel statistical analysis framework to identify peptide isomers and locate the isoAsp sites using mass spectrometry.• Provided technical expertise in mass spectrometry to interdisciplinary research teams from both academic and industry settings (e.g., organic chemistry department, ThermoFisher, Waters, and research groups at other universities).Project: Innovative Isomer Characterization via Advanced Mass Spectrometry Techniques• Developed analytical methods to characterize peptide isomers using tandem MS, offering a streamlined MS approach to pinpoint the isomerized sites.• Formulated an unbiased method for quantifying structural differences in Asp/isoAsp fragments using Traveling Wave Ion Mobility Spectrometry Mass Spectrometry (TWIMS-MS).• Developed an isomer differentiation method to identify isoAsp residues in an isomer mixture using Waters cyclic ion mobility. (Project outcome to be presented at ASMS 2021 in collaboration with Waters)Project: Peptide Isomers Differentiation via Mass Spectrometry and Statistical Analysis.• Developed a statistical framework to differentiate similar mass spectra observed in peptide isomers.• Collected extensive datasets to provide comprehensive insights into the differentiation of peptide isomers using various fragmentation methods, such as CID, HCD, ETD, and RDD.• Successfully differentiated peptide isomers in human lens lysate digestion with CID, expanding the MS capability to differentiate isomers.Selected Collaborations:1. Provided expertise to the UCLA Joseph Loo Group, facilitating the collection of top-down protein data with 213 nm UVPD on the modified ThermoFisher Velos Pro Orbitrap.2. Provided MS measurement to Dr. Richard Hooley’s organic chemistry group for molecular assessment and structure elucidation on fragile self-assemble cages, resulting in four publications.

Riverside, Ca, Us

• Assisted and implemented flipped classroom & PhET simulation activities for educational research.• Head TA in General Chemistry 001A discussion with 200 students. • Head TA in General Chemistry 002C discussion for chemistry major students only.• Led Generate Chemistry 001A and 001B labs with 60 students.

Doctor Of Philosophy - Phd, Analytical Chemistry

Master Of Science - Ms, Analytical Chemistry

Bachelor Of Science - Bs, Chemistry/ Material Sciences

Associate’S Degree, Biology, General