Iván Caballero Email & Phone Number

Basel, Baselstadt, Ch

+ Assay development - Development of medium and high-throughput biochemical and cellular assays for hit identification, specificity/selectivity analysis and triage in drug discovery programs.+ HTS - Designing, planning and execution of high-throughput biochemical and cellular compound screens. Assay optimization, miniaturization and adaptation to robotics. In vitro data management: extensive data processing for the generation of comprehensive information packages. Statistical hit selection, triage and compound profiling

San Diego, California, Us

+ Screening - Compound management, execution, analysis and publication of biochemical high-throughput screenings for immunology and oncology targets+ Assay development - Development of medium and high throughput assays for immunooncology+ Product development from concept to transfer to manufacturing+ Protein expression and purification

Madrid, España, Es

+ CNB-CSIC, Dept. of Molecular and Cellular Biology - Gene edition by CRISPR-Cas9 technology. Overall strategy design, guide RNA engeenering, molecular and cellular in vitro validation and generation of knockout mice for albinism. + CNB-CSIC, Dept. of Immunology and Oncology - Application of CRISPR-Cas9 technology to generate stable protein-deficient B cell lines.

Brentford, Middlesex, Gb

+ HTS - Designing, planning and execution of high-throughput biochemical and cellular compound screens. Assay optimization, miniaturization and adaptation to robotics. In vitro data management: extensive data processing for the generation of comprehensive information packages. Statistical hit selection, triage and compound profiling+ Management - Mentoring and supervision of junior scientists, technician teams and HTS platforms. Biology project management+ Lab creation - Acquisition, testing and setup of automatized laboratory equipment and HTS platforms+ Communication - Elaboration and communication of decision-making reports, participate in discussions and generate and execute actions in cross-functional teams (Pharma-Pharma/Pharma-Academia)+ Biology - Deep understanding of complex cellular biology systems. Data mining for hit deconvolution in phenotypic screens. Drug target identification and validation. Natural products screeningAchievements:+ 2 Candidate Selections: Alzheimer’s disease and Malaria+ Identification and patent register of drug bioproducer for Fabry’s disease

Brentford, Middlesex, Gb

+ Assay development - Development of medium and high-throughput biochemical and cellular assays for hit identification, specificity/selectivity analysis and triage in drug discovery programs. Cell culturing of inmortalized and primary cells. DOE+ MoA - Characterization of pharmacological targets and mode of action of compounds. Detailed enzymology works in steady and pre-steady state. Compound profiling for hit to lead and lead to candidate (SAR). + Reagent generation and validation - Construct design, cloning, expression, purification and analysis of recombinant proteins in bacterial and eukaryotic cells. Antibodies and small molecules modification. Biological and chemical reagents for assaysAchievements:+ 50+ assays developed in 10+ technologies, from 96- to 1536-well, biochemical and cellular, all levels of automatization+ Assay toolbox for neurosciences to elucidate Candidate MoA+ Design and implementation of a biological reagents production platform: 8 proteins designed, expressed and purified