Iiro Kiiski Email & Phone Number

Oulu, North Ostrobothnia, Finland

- Study director role for drug-drug interaction (CYP, UGT) and permeability studies- Management of timelines and work in laboratories, and supervision of scientists and laboratory assistants- Processing, interpretation and reporting of research data, and development of calculation, modeling, and similar tools- Scientific communication and consultation with clients

Tokyo, Japan

Research on stimuli-responsive synthetic ion channels for applications in molecular roboticsMolecular robots are cell-like systems composed of molecular sensors, calculators and actuators, integrated in a micrometer-sized body, that have potential applications in numerous fields, such as targeted drug delivery. However, to allow controlled responses to external stimuli, there needs to be a way to control the movement of molecules in and out of the liposome casing of the robot, which has proven difficult to date. The purpose of this multi-disciplinary project is to create molecular robots that are able to respond to external stimuli via controllable synthetic ion channels made from metal-organic polyhedra, porous molecules formed by the self-assembly of metal ions and organic linkers. Ability to control molecular traffic to and from the robot constitutes a real advance towards real-life applications of molecular robotics.Funding: Japan Society for the Promotion of Science

Helsinki, Southern Finland, Finland

Research on the commercialization potential of immobilized enzyme microreactors based on the concept developed during my PhD thesis. Work resulted in 1 invention disclosure and 1 patent application (pending).A "Research to Business" -project funded by Business Finland

Helsinki Area, Finland

PhD thesis project: Immobilized enzyme microreactors in drug metabolism researchThe field of metabolism research would greatly benefit from the implementation of enzyme assays on immobilized enzyme microreactors. Most importantly, the use of flow conditions would allow for the spatiotemporal control of reaction parameters on demand by simply altering the chemical composition of the flow. However, immobilization of membrane-bound enzymes, which constitute the majority of enzymes responsible for human drug metabolism, has proven difficult, as the current immobilization approaches are not feasible for membrane proteins or result in unwanted alterations in enzyme function.The main goals of my thesis were twofold: (1) to develop a novel immobilization approach suitable for the immobilization of membrane-bound enzymes, without detrimental effects on enzyme activity or enzyme kinetics, and (2) to establish a microreactor platform for the study of drug metabolism in flow conditions. A central part of the thesis was also the utilization and characterization of a novel class of polymers, off-stoichiometric thiol-enes (OSTE), chosen for both their facile surface modification, and the ability to generate material-induced hypoxia.The thesis project resulted in 3 peer-reviewed articles, dissemination of results in 6 international conferences and 1 invention disclosure. The microreactor technology developed in the thesis project is now widely utilized within the research group and its commercialization is currently investigated in a Business Finland –funded project.Thesis available online: https://helda.helsinki.fi/handle/10138/324276

Tokyo, Japan

Helsinki, Finland

Development of Immobilized Enzyme Microreactors for Studying Cytochrome P450 Mediated Drug Metabolism

Helsinki, Finland

Chemical microsystems groupImmobilization of enzymes on microfabricated chip systems

Helsinki, Finland

Modern analytical chemistry (MAC) unit Research on ambient mass spectrometric techniques

Doctor Of Philosophy - Phd, Pharmaceutical Sciences, Passed With Distinction

Thesis title: Immobilized enzyme microreactors in drug metabolism research

Master Of Science (Tech.), Biotechnology

Helsinki Region Biotechnology Educational Programme HEBIOT (A multidisciplinary collaborative programme by University of Helsinki.

Bachelor Of Science (Farmaseutti), Pharmacy

Activities and Societies: Secretary, Helsinki Pharmacy Students’ Association, 2014 Student representative, Faculty of Pharmacy Admission.

Education record