Leading drug‐research programs in the areas of epigenetical regulation of cancer, metabolism and inflammation using small molecules.

Development of molecular biology approaches to identify mode of action of herbal extracts in the treatment of cancer, inflammation and metabolic disorders, and translation of them into new product ideas.

Elucidation of molecular mechanisms of tumour metabolism regulation.Management and Project Leading Experience:• Management: supervised and coached PhD, masters and internship students to successful theses completion. Successfully led recruitment efforts into the lab, resulting in direct supervision and training of new lab members• Finances: met financial and budgetary responsibility for internal and external research projects• Project Management: proven success in developing and achieving project schedules and milestone delivery• Business Development and Marketing: experience presenting and pitching projects to possible investors• Communication skills: exemplary communication, interpersonal and problem-solving skillsTechnical and Laboratory Proficiencies:• strong background in biochemistry and molecular/cellular biology• design and performance of phenotypic screens assays • CRISPR technology: design and creation of stable knock-in cell lines, mono- and polyclonal dual reporter cell lines • genome wide massively parallel sequencing and analysis: RNAseq, ChIPseq, MBDseq, bisulfite sequencing • numerous tissue culture techniques • molecular cloning• protein expression and purification, protein analytics, antibody generation• immunoprecipitation, SILAC, mass-spectrometry • luciferase assays, ELISA• immunofluorescence, confocal microscopy

Small molecules-modulated gene expression

Small molecules-modulated active DNA demethylation

Dosage compensation in D. melanogaster

During my work at EMBL I significantly contributed to the understanding of molecular mechanisms of dosage compensation in D. melanogaster. I purified and characterized a novel Non Specific Lethal (NSL) protein complex involved in general transcriptional regulation, and demonstrated the involvement of the histone acetyl transferase MOF, expanding the role of NSL beyond dosage compensation.

DNA replication and genome stability in S. pombe

Elg1-RFC and Ctf18-RFC in DNA replication and repair