Jacob Mccright Email & Phone Number

Gaithersburg, Md, Us

Germantown, Maryland, United States

College Park, Maryland, United States

- Implemented novel computational modeling and machine learning algorithms to identify optimum nanoparticle formulations for lymphatic transport and mechanisms governing lymphatic transport.- Engineered polymeric nanoparticles that efficiently entered lymphatics and reached lymph nodes by optimizing nanoparticle size, shape, surface charge, and surface functionalization to improve immunotherapy efficacy.- Developed in-vitro lymphatic vessel models to probe mechanisms governing nanoparticle transport and how extracellular cues influence transport into lymphatic vessels to further inform nanoparticle design.- Identified the composition of the protein corona formed on the surface of nanoparticles within lymph, the effect of protein adsorption on lymphatic transport, and the immunogenicity of nanoparticle-protein complexes with respect to nanoparticle formulation using mass spectrometry and flow cytometry.

Gaithersburg, Maryland, United States

Purification Processes Sciences Supervisor: Dr. Thomas Linke- Analyzed and developed methods of using affinity chromatography to purify a viral vector serving as a therapeutic agent.- Successfully created novel chromatography columns using antibody-conjugated monolithic technology to bind and release the therapeutic under native conditions.- Optimized formulation and elution conditions to retain therapeutic efficacy.- Compiled findings into poster and presentations to share with peers as well as senior members of the company.

- Investigated methods of creating safer lentiviral vectors to deliver gene therapy treatments while learning many lab techniques such as: genetic and molecular cloning, transfection, transduction, PCR, and cell culture. - Used the CRISPR/Cas9 gene editing system to create gene-knockout cell lines to be used to engineer highly transfectable cell lines and study transfection mechanisms.- Helped develop and analyze methods to increase the purity and titer of lentiviral vectors using chromatography by engineering the vectors to express specific protein tags on their surface.

Silver Spring, Maryland, United States

- Designed and performed MRI simulations on virtual patients to investigate MRI safety at various operating settings and tissue composition.- Created a database of possible medical device placement in a patient undergoing MRI using MatLab and JAVA for data and image processing.- Investigated the effects of electrical and magnetic fields on medically implanted devices and helped evaluate the safety of those devices during an MRI procedure.

Bachelor Of Science (B.S.), Bioengineering And Biomedical Engineering

Activities and Societies: Dean's Scholarship Biomedical Engineering Society (BMES) Dean's ListCompleted Biotechnology and Therapeutics.

Doctor Of Philosophy - Phd, Bioengineering

Activities and Societies: American Heart Association Predoctoral Fellow 2021-2023 Clark Doctoral Fellow 2022-2023PhD Advisor: Dr..