Jamie H. Aldridge, Phd, Pa-C Email & Phone Number

High Point, Nc, Us

High Point, North Carolina, United States

› Maintained an impact-first mindset to support the successful launches of Vyvgart and Vyvgart Hytrulo across multiple indications with exceptional healthcare provider relationships and insight generation.› Responsible for ongoing support of clinical trial sites and externally sponsored research projects on an ongoing basis.› Worked with internal medical affairs on discrete projects, including ground-up development of advisory boards, conference symposia, competitive data analytics and… Show more › Maintained an impact-first mindset to support the successful launches of Vyvgart and Vyvgart Hytrulo across multiple indications with exceptional healthcare provider relationships and insight generation.› Responsible for ongoing support of clinical trial sites and externally sponsored research projects on an ongoing basis.› Worked with internal medical affairs on discrete projects, including ground-up development of advisory boards, conference symposia, competitive data analytics and focus-group discussions.› Lead US medical affairs through multiple major academic conferences: Planning, execution, insights and action items in a strongly cross-functional and global environment with C-Suite expectations of specific outcomes. › Developed and delivered several culture- and experience- changing initiatives.› Mentored and coached multiple MSLs new to the company and industry through their first years at argenx. Show less

Durham, North Carolina, United States

Durham, North Carolina, United States

Allergan was acquired by AbbVie in May, 2020.

Raleigh-Durham, North Carolina Area

Greensboro, North Carolina, United States

Physician Assistant on the Neurohospitalist team. I left the position because of a family move to GA.

Online biological and social sciences tutor, writing coach and editor.

Winston-Salem, Nc

Alcohol use disorders are a rampant economic and health concern in the United States; however, the neurobiological underpinnings of this disorder are not well understood. Previous work has shown that chronic ethanol (EtOH) exposure and withdrawal downregulates dopamine transmission in the nucleus accumbens (NAc) which may be due to upregulated presynaptic receptor proteins such as kappa opioid receptors (KOR) and dopamine D2/D3 autoreceptors (D2R/D3R). Changes in receptor-system function may… Show more Alcohol use disorders are a rampant economic and health concern in the United States; however, the neurobiological underpinnings of this disorder are not well understood. Previous work has shown that chronic ethanol (EtOH) exposure and withdrawal downregulates dopamine transmission in the nucleus accumbens (NAc) which may be due to upregulated presynaptic receptor proteins such as kappa opioid receptors (KOR) and dopamine D2/D3 autoreceptors (D2R/D3R). Changes in receptor-system function may, in part, drive symptoms of EtOH withdrawal and relapse behavior. The present body of work identified some of the effects of five weeks of chronic intermittent EtOH (CIE) exposure on EtOH withdrawal behavioral phenotypes, including EtOH drinking parameters and anxiety/compulsive- like behavior, as well as dopamine transmission and presynaptic receptor function in the NAc of C57BL/6J mice. We found that CIE increased EtOH drinking and anxiety/compulsive-like marble burying compared to air-exposed mice, phenotypes that were reduced by KOR blockade and replicated with KOR activation. Neurobiological examination of NAc dopamine transmission with slice fast scan cyclic voltammetry showed reduced dopamine release, augmented uptake and increased sensitivity of KORs and D3Rs following five weeks of CIE exposure. A subsequent examination of interactions between KORs and dopamine autoreceptors showed that D3Rs and KORs are functionally linked. Finally, the effects nalmefene (NAL), a high-affinity KOR partial agonist used to treat EtOH use disorders, on dopamine terminal and KOR function were examined to understand its clinical efficacy. NAL reduced dopamine uptake rates and reversed the dopamine- decreasing effects of KOR activation selectively in brain slices from CIE-exposed mice, likely due to the increased affinity and distinct effects of NAL on KORs. We hope that this work supports the development of KOR-specific ligands to reduce ethanol withdrawal symptoms and relapse drinking. Show less

Graduated summa cum laude with dual degrees in biology and psychology and a minor in chemistry. I maintained a rigorous class schedule in addition to several on- and off- campus jobs, including University Ambassador and Slane Student Center Manager.

During this internship, I worked to discern the interaction between cocaine, ethanol and disulfiram in non-human primates. The internship culminated in a poster that was presented at an end-of-summer conference. Additional details available upon request.

Master’S Degree, Physician Assistant Studies

Doctor Of Philosophy (Ph.D.), Neuroscience

Bachelor Of Science (Bs) Biology, Summa Cum Laude

Bachelor’S Degree, (Bs) Psychology, Summa Cum Laude