Chen-Yu Lee, M.D. Email & Phone Number

Baltimore, Maryland, United States

• Conducted single-cell analysis on a dataset comprising 2M+ cells obtained from multiplex immunohistochemistry staining and identified distinct lymphoid and myeloid subclusters, establishing their correlation with the progression of lupus nephritis• Utilized statistical testing, machine learning algorithms, and medical insights to bridge CD68+ myeloid cluster findings with practical solutions for membranous lupus nephritis Research Topics: . Lupus. Lupus nephritisSkill sets:. Biostatistics analysis. Single-cell RNA sequencing analysis. Spatial transcriptomics analysis. Multiplex immunohistochemistry analysis. Urine proteomics analysis. Experimental design. Literature review. Scientific communication

Research Topic: Genetics in Human Hereditary Hearing DiseasesResearch Description:. Analyzed NGS panel/WES/WGS data for variant identification and established prognostics and diagnostics . Combined clinical and bioinformatics insights to identify the molecular mechanisms of hereditary hearing impairment and enable precision medicine. Identified 8 novel variants in Waardenburg syndrome and two distinct phenotype-genotype correlations in unilateral hearing loss patients. Established the largest hearing impairment database in Taiwan with 7000+ patients' genotypes and phenotypes information, facilitating genomic research and prognostics establishment . Drafted grant proposals and successfully received USD 30K grants from the Ministry of Health and Welfare for rare disease prevention in 2022. Bioinformatics Analysis Applied: NGS analysis (GATK, Sentieon, Dragen), variant annotation (ANNOVAR), common variant association test (SAIGE), rare variant association test (SAIGE-GENE), genomic data quality control (PLINK, KGGseq), image segmentation (Unet using Keras), bulk RNAseq analysis (Kallisto, DAVID), single-cell RNAseq analysis (Cell Ranger, Seurat, UMAP)

Taipei City, Taiwan

• Identified potential gene therapy and immunotherapy products through a literature review of over 50 research papers and performing due diligence checks on one biotechnology company per week• Counseled over 15 investment cases, one leading to a successful USD 1M deal on fusion protein technology

Taipei City, Taiwan

. Treated oncology patients with immunotherapies and chemotherapies and managed related complications. Presented immunotherapy trial results to the management teams to invest in promising therapeutic agents

Taiwan

• Researched clinical trial regulations, protocols, criteria, terms, and mechanisms of drugs• Participated in 12 clinical trial protocol translations for top 10 pharmaceutical companies in the world

. Provided clinical care to 1,000+ patients in internal medicine wards, including informing patients about their disease insights and prognosis according to their blood and genetic testing results. Assisted in 500+ surgery and helped collect cancer samples for pathology and molecular diagnosis

Project Name: Profiling the timing of Rbfox3 deletion in the hippocampal dentate gyrus of three cell-type specific mouse Cre lines: Gad2-Cre::Rbfox3loxp/loxp, Pomc-Cre:: Rbfox3loxp/loxp, and Camk2a-iCre:: Rbfox3loxp/loxp”Methods and Results:. Confirmed the Rbfox3 deletion in the GABAergic interneurons of hippocampal dentate gyrus may induce seizures in mice . Ascertained the deletion of Rbfox3 in interneurons of the three mice lines before postnatal day 7 using genotyping, immunohistochemistry (IHC) staining, and confocal microscopy

Tokyo, Japan

Research Topic: quality of life and sleep in Japnese elderlyMethods:. Investigated the relationship between quality of life and quality of health of the elderly people in Kodaira City, Tokyo, and processed the research data by SPSS software • Led a four-person project and designed the experiment, coordinated researchers and community residents in Japanese, and ensured the execution of the project was right on scheduleResults:. The quality of life of the Japanese elderly living in Kodaira, Tokyo, was associated with their quality of sleep. . The education level was was correlated with higher scores in quality of life and quality of health.

Doctor Of Medicine - Md, Medicine

International Exchaged Student Program, Public Health

Master Of Science - Ms, Bioinformatics