Medicinal Chemistry Hit-to-Lead and Lead Optimization, Global Hit ID team

Medicinal Chemistry Hit-to-Lead and Lead Optimization

Infectious Disease: Telaprevir backup molecules, HCV NS3•4A proteasePain: GPCR antagonism, target: CGRP

Hepatitis C Virus: NS3•4A viral protease inhibition• Design and synthesis of α-ketoamide tetrapeptides as hepatitis C viral protease inhibitors• Synthesis of a variety of molecular classes in support of research goals: peptides, peptidomimetics, macrocycles, nucleosides, and small molecule diketoacids

Associate Chemist, Pioneering Research Group (February 1995 – August 1997)• Researched and synthesized novel hydantoin derivatives and sulfobetaines as biocides, Diels-Alder adducts as isotactic polypropylene clarifiers, and the Eschweiler-Clarke methylation of secondary alkyl amines• Experimental planning, operation, and maintenance of Mettler RC-1 reaction calorimeter with Chemical Engineering group for Process Chemistry evaluations and Research scale-up• Pilot plant experience up to 50 gallon scaleSenior Research Assistant (July 1993 – February 1995)• Optimized reaction to prepare quaternary ammonium salts of long chain 3° alkyl amines• Investigated reaction conditions and workup to obtain low flashpoint raw material product• Operated primarily in 2L high pressure Parr reactors• Hazardous Waste Coordinator