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Principal Scientist with over 5 years of biotech research experience (14 years including academia) working both independently and in a matrixed environment to develop antibody therapies against novel targets• Project leader that can drive progress of multiple programs simultaneously through collaboration, resource allocation, CRO and project team management, design/execution of complex experiments, and clear communication of results and recommendations• Established people and project manager who successfully managed multiple direct reports, mentoring of junior scientists, and completion of formal project management training (CAPM and internal company training)• Major intellectual and scientific contributions to the fields of immunology, cancer immunotherapy, and cell death as evidenced by 4 patents and 10 publications on these topics in peer-reviewed journals, including Science Immunology and Nature Communications• Expertise in a wide variety of immunology and molecular biology techniques using novel mouse models, primary cells, and established cell lines in the context of developing of antibody drug conjugates, immune-oncology therapies, and anti-viral therapies
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Associate Principal ScientistMerckWillow Grove, Pa, Us
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Principal ScientistImmunome, Inc. Jan 2023 - Oct 2024 -
Senior Research ScientistImmunome, Inc. Nov 2020 - Dec 2022
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Research ScientistImmunome Apr 2019 - Nov 2020Exton, Pa
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Postdoctoral FellowThomas Jefferson University Jan 2017 - Apr 2019Philadelphia, PaDissecting the mechanisms of cell death regulation and their effects on the immune system, homeostasis, and mouse development • Investigating how RIPK1 can regulate apoptosis and necroptosis in the context of T cell biology and mouse development utilizing a variety of knockout and knockin mouse models as well as potential applications to autoimmune and inflammatory diseases• Independently developing and planning multiple high impact projects simultaneously• Serving as a mentor for masters and undergraduate students by participating in thesis committee meetings and summer research programs -
Phd Candidate In Immunology And Microbial PathogenesisThomas Jefferson University Jan 2014 - Dec 2016Philadelphia, PaInvestigated the role of cell death pathways in the development and function of lymphocytes as well as embryonic and perinatal development of the mouse under the mentorship of Dr. Jianke Zhang• Quickly contributed to a new field of study (cell death) as evidenced by a 1st author publication within 1 year of joining a laboratory• Demonstrated in depth knowledge of fundamental immunology and a wide variety of experimental techniques that can be applied to studying immune cell function, autoimmune disease, and cancer• Received the Thomas Jefferson Thesis Award for outstanding written dissertation and thesis defense by displaying a wide range of knowledge in immunology and cell death and effectively communicate these disciplines in a written and oral manner
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Phd Student In Immunology And Microbial PathogenesisThomas Jefferson University Sep 2011 - Dec 2014Developed a cancer immunotherapy approach to target melanoma using chimeric antigen receptor (CAR)-expressing natural killer (NK) cells working with a group of scientists and clinicians• Coordinated a multi-institutional group of clinicians and basic scientists to drive progress of several cancer immunotherapy projects• Set up a new lab at Thomas Jefferson University, including all equipment, reagents, and IBC approvals to develop anti-melanoma specific CAR natural killer cells in a clinical setting• Worked with human cell lines as well as melanoma patient samples to develop novel therapies• Developed a vast knowledge and passion for cancer immunotherapy participating in tumor immunology groups at Jefferson and Society for the Immunotherapy of Cancer (SITC) meetings
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Research TechnicianPenn State University May 2010 - Aug 2011State College, PennsylvaniaInvestigated gene regulation by transcription factors in budding yeast in the lab of Dr. B. Frank Pugh within the Center for Eukaryotic Gene Regulation• Optimized and standardized chromatin immunoprecipitation sequencing (ChIP-seq) procedures, streamlining this technique by reducing starting material by 50%• Organized and maintained a library of transcription factor-tagged budding yeast for the whole lab• Prepared samples for high throughput sequencing projects in coordination with postdoctoral fellows
John Dowling Skills
John Dowling Education Details
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Immunology And Microbial Pathogenesis -
Biochemistry And Molecular Biology
Frequently Asked Questions about John Dowling
What company does John Dowling work for?
John Dowling works for Merck
What is John Dowling's role at the current company?
John Dowling's current role is Associate Principal Scientist.
What is John Dowling's email address?
John Dowling's email address is jd****@****ome.com
What schools did John Dowling attend?
John Dowling attended Thomas Jefferson University, Penn State University.
What skills is John Dowling known for?
John Dowling has skills like Cell Culture, Western Blotting, Cell Biology, Molecular Biology, Microsoft Office, Flow Cytometry, Biochemistry, Life Sciences, Research, Science, Dna Sequencing, Microsoft Word.
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