John Dowling Email & Phone Number

Willow Grove, Pa, Us

Exton, Pa

Philadelphia, Pa

Dissecting the mechanisms of cell death regulation and their effects on the immune system, homeostasis, and mouse development • Investigating how RIPK1 can regulate apoptosis and necroptosis in the context of T cell biology and mouse development utilizing a variety of knockout and knockin mouse models as well as potential applications to autoimmune and inflammatory diseases• Independently developing and planning multiple high impact projects simultaneously• Serving as a mentor for masters and undergraduate students by participating in thesis committee meetings and summer research programs

Philadelphia, Pa

Investigated the role of cell death pathways in the development and function of lymphocytes as well as embryonic and perinatal development of the mouse under the mentorship of Dr. Jianke Zhang• Quickly contributed to a new field of study (cell death) as evidenced by a 1st author publication within 1 year of joining a laboratory• Demonstrated in depth knowledge of fundamental immunology and a wide variety of experimental techniques that can be applied to studying immune cell function, autoimmune disease, and cancer• Received the Thomas Jefferson Thesis Award for outstanding written dissertation and thesis defense by displaying a wide range of knowledge in immunology and cell death and effectively communicate these disciplines in a written and oral manner

Developed a cancer immunotherapy approach to target melanoma using chimeric antigen receptor (CAR)-expressing natural killer (NK) cells working with a group of scientists and clinicians• Coordinated a multi-institutional group of clinicians and basic scientists to drive progress of several cancer immunotherapy projects• Set up a new lab at Thomas Jefferson University, including all equipment, reagents, and IBC approvals to develop anti-melanoma specific CAR natural killer cells in a clinical setting• Worked with human cell lines as well as melanoma patient samples to develop novel therapies• Developed a vast knowledge and passion for cancer immunotherapy participating in tumor immunology groups at Jefferson and Society for the Immunotherapy of Cancer (SITC) meetings

State College, Pennsylvania

Investigated gene regulation by transcription factors in budding yeast in the lab of Dr. B. Frank Pugh within the Center for Eukaryotic Gene Regulation• Optimized and standardized chromatin immunoprecipitation sequencing (ChIP-seq) procedures, streamlining this technique by reducing starting material by 50%• Organized and maintained a library of transcription factor-tagged budding yeast for the whole lab• Prepared samples for high throughput sequencing projects in coordination with postdoctoral fellows

Doctor Of Philosophy (Ph.D.), Immunology And Microbial Pathogenesis

Bachelor'S Degree, Biochemistry And Molecular Biology