Jonathan Messer Email & Phone Number

Gainesville, Florida, United States

West Lafayette, Indiana, United States

● Assist in preclinical development of novel, targeted pharmaceuticals for musculoskeletal diseases● Identify and establish preclinical models to understand efficacy of bone-related pharmaceuticals● MicroCT and mechanical testing of bone specimens● Histology and staining of bone specimens● Co-managed small team of animal technicians

Miami, Florida, United States

● Supervision and mentorship of R&D Research Associates ● Lead scientist in Interventional Pain Therapies team● Develop in vitro (primary human bone marrow skeletal stem cells and nucleus pulposus cells) and ex vivo (biomechanical compression testing) models to establish mechanism of action of allogeneic regenerative medicine products intended for spine application ● Laboratory investigation and characterization of allogeneic grafts over life cycle of products● Design and execute testing plans and research strategies to gather evidence to support FDA regulatory submissions● Technical writing (SOPs, Work Instructions, Research Protocols and Reports)

● Develop in vitro models to establish mechanism of action and to characterize products● Design and execute testing plans and research strategies to support FDA regulatory submissions● Technical writing of SOPs, Work Instructions, Research Protocols and Reports

Gainesville, Florida Area

● Led large-scale preclinical studies to examine the role of oral inflammation in medication-related osteonecrosis of the jaw, a disease affecting primarily older patients with osteoporosis or cancer ● Managed breeding and experimental colonies of rice rats (Oryzomys palustris), a non-conventional rodent model of periodontitis ● Wrote manuscripts published in peer-reviewed journals and presented research posters at professional conferences● Key role training and supervising undergraduate and graduate students, and non-student employees

Gainesville, Fl

● Led large-scale preclinical studies to examine the role of oral inflammation in medication-related osteonecrosis of the jaw, a disease affecting primarily older patients with osteoporosis or cancer ● Managed breeding and experimental colonies of rice rats (Oryzomys palustris), a non-conventional rodent model of periodontitis ● Performed histopathologic and gross analysis of healthy and diseased bones and jaw tissues, molecular biology and immuno-assays for gene and protein expression, three-point bending mechanical tests of long bones, dynamic and static histomorphometry in rodents, and densitometry● Wrote multiple manuscripts published in peer-reviewed journals and presented research posters at professional conferences

Department Of Nutrition

● Managed experiments to examine the role of iron and prolactin in the differentiation of osteoblasts and adipocytes using primary cultures of skeletal stem cells● Independently designed experiments, implemented new methodology, accrued data, and analyzed results● Implemented molecular biology techniques to determine protein and gene expression● Managed all aspects of daily lab operation● Key role in training and supervising undergraduate and graduate students● Wrote manuscripts for publication in peer-reviewed journals

● Managed incoming submissions and maintained comprehensive database of authors and associate editors

Department Of Biology

● Executed experiments to investigate neural development in marine mud snails (Ilyanassa obsoleta) and oysters (Crassostrea virginica)

Doctor Of Philosophy (Phd), Nutrition Sciences

Bachelor Of Science (Bs), Biology, General