Jon Ladd Email and Phone Number

• Develop workflows to produce novel assays for multiple pharmaceutical clients, including process improvement, methods development, and analysis optimization• Balance work between multiple clients to provide timely delivery of milestone-based development and services-based projects• Prepare statements of work and costing estimates for new projects• Interface with scientific, marketing, software, and manufacturing teams to expand product capabilities and reach• Manage multiple direct reports

• Led development of novel immunofluoresent assays to enumerate and characterize circulating tumor cells and white blood cells• Wrote SOPs to support assay transfer• Created custom R and Groovy scripts for extraction, analysis, and visualization of data

• Developed strategies for diagnostic development for longitudinal research studies for discovery and confirmation of biomarkers for diagnosis and assessment of risk and recurrence in solid tumor cancers• Evaluated various technologies to carry out large-scale validation studies in cohorts of several thousand serological samples that would minimize sample usage and maximize throughput• Developed customized assays (Luminex, ELISA, Chemiluminescence, and high-density microarrays) for protein-based diagnostics in solid tumor cancers• Directed cross-functional efforts with epidemiologists, clinicians, and statisticians, at academic institutions and businesses for clinical validation of biomarkers• Managed technicians and provided guidance for postdoctoral fellows conducting diagnostic development• Contributed to grant preparations, revisions, and submissions• Created custom R scripts for extraction, analysis, and visualization of data• Contributed to 7 original manuscripts and 4 invited presentations

Provided scientific input and design for microarray project development to labs at Fred Hutchinson Cancer Research Center and MD Anderson Cancer Center

• Designed, managed, and innovated autoantibody-based diagnostic development independently and in support of longitudinal research studies in lung, breast, and colon cancer directed by other lab members• Developed novel methods for identification of immunogenic proteins and epitopes using mass spectrometry and protein and peptide arrays• Integrated multiple datasets (proteomics, transcriptomics, immunomics, genomics) in a systems biology approach to diagnostic development• Directed numerous cross-functional efforts with research labs, other academic institutions (e.g. University of Washington, University of California-Davis), and companies (Invitrogen, Roche Nimblegen, MagArray)• Provided input and technical assistance on colleagues’ manuscripts and presentations• Contributed to 7 original manuscripts and 6 conference presentations and posters

• Developed, characterized and implemented novel surface chemistries for highly sensitive and robust diagnostics using surface plasmon resonance (SPR) sensors for biomarkers in a variety of matrices, including plasma and honey• Contributed to microfluidic sensor designs• Formulated novel DNA-antibody conjugate platforms for improved sensitivity and multi-channel detection capabilities• Contributed to 10 original manuscripts, 3 book chapters, and 16 conference presentations and posters