Jorge Lima Email & Phone Number

I obtained my degree in Biology at the Faculty of Sciences and Technology of the University of Coimbra (July 2000) and my PhD in Biomedicine at the Faculty of Medicine of the University of Porto in December 2006. At the moment I am Vice-Director of Ipatimup and also researcher in the "Cancer Signalling & Metabolism" group at i3S-Ipatimup. I am also affiliated professor at the Medical Faculty of the University of Porto and I have molecular diagnostic activities at Ipatimup, more precisely molecular diagnosis of adult and pediatric brain tumors. My research focuses on understanding the oncogenic properties and inherent biomarkers of adult and paediatric brain tumours. I am also interested in the crosstalk between altered metabolism and the oncogenic properties of cancer cells. My work has provided important insights for the role played by metabolic enzymes in inherited neoplasias and the effects of mitochondrial deficiency in cancer cells. I study brain tumours, and I contributed to understand the role played by IDH and TERTp mutations, identify biomarkers of therapy resistance, test novel delivery methods and investigate the metabolic features of stem-like cells. Recently I became involved in paediatric brain tumours and in translating their genomic features to the clinical practice, by creating a fruitful collaboration between Ipatimup and the departments of paediatric oncology of 3 reference clinical centres in Portugal - CHUSJ, IPO-Lisboa and Hospital Pediatrico de Coimbra. I am currently PI of 4 projects, 3 of them specifically dedicated to CNST. I have supervised 5 Msc and 3 PhD students to completion, and I am involved in several teaching activities. I have been leading collaborations between i3S/Ipatimup and international institutes, such as Roswell Park Cancer Institute, Weill Cornell Medical College, Wurzburg University and Heidelberg University. I am a permanent member of the Scientific Committee of the international conference “Porto Cancer Meeting”, member of the board in ASPIC (Portuguese Association for Cancer Research) and I integrate the Paediatric Oncology Tumour Board at CHUSJ. I have co-authored >40 peer-reviewed publications, with >3000 citations and a H-index of 23.

Listed skills include Cancer, Biologia Molecular, Cancer Research, Biologia Celular, and 17 others.