Justin Guild work email
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A Biopharmaceutical Development Expert with eighteen years of continuous experience in research and GLP labs. Utilized ever expanding skill sets in the fields of Immunology, Cellular, and Molecular Biology to support and facilitate drug discovery with a high level of competence and speed. Flexibility, excellent communication and interpersonal skills enable a high level of effectiveness both independently, and in a team, to achieve significant contributions to research and GLP preclinical assay development. Have recognized expertise with multiparameter Flow Cytometry, molecular biology, cell-based assays, ELISA and cell culture. Have advanced the development of cardiovascular, rare disease, cancer, vaccine, and type I diabetes drug candidates.
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UndisclosedUndisclosed Oct 2024 - Present -
Senior ManagerModerna Apr 2022 - PresentNorwood, Massachusetts, United States• Expansion of duties listed under former Manager role including Bioassay Team Operational and Early Program Lead.• Continuation of cell based potency assay development, qualification and transfer activities.• Potency, cellular and molecular biology SME. -
ManagerModerna Dec 2019 - PresentNorwood, Massachusetts, United States• Developed, optimized, pre-qualified and implemented multiple cell-based bioassays for lead programs• Authored method development, assay robustness, and pre-qualification reports. • Facilitated assay transfers to QC bioassay group. • Rapidly developed and implemented a cell-based protein expression bioassay for the Moderna Sars-Cov-2 vaccine. • Implemented a ribosomal engagement assay (REDA) for seasonal and/or personalized programs.
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Scientist, Preclinical PharmacologyModerna Therapeutics Mar 2015 - Dec 2019Cambridge, Massachusetts• Lead LDLR program to key findings regarding effect of inclusion of miR recognition elements on expression, mRNA codon optimization performance, LDLR independence properties of LNPs, G6 and LNP derivatives screening. • Demonstrated a dramatic improvement in the duration of LDL-c lowering in the mouse animal model in a key PK/PD study. Demonstrated resistance to PCSK9 downregulation of PCSK9 LDLR binding mutants in vitro.• Additional five patents published during this time regarding mRNA technology (20150086614, 20150111248, 20150246139, 20150368665, 20150376648)
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Principal Research AssociateModerna Apr 2013 - Mar 2015Cambridge, Massachusetts, United States• Implemented flow cytometry and ELISA based methods to successfully detect extracellular, intracellular and secreted proteins. Optimized miniaturized Western blot (Capillary Electrophoresis) method to rapidly characterize in vivo protein expression.• Five patents published during this time relating to modified polynucleotide performance and production of protein (20130259923, 20130259924, 20140010861, 20150064235, 20150064236)
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Senior Research AssociateModerna Nov 2011 - Apr 2013Cambridge, Massachusetts, United States• End to end mRNA synthesis, characterization of mRNA performance, including nucleotide chemistries evaluation, in vitro, in vivo and ex vivo protein expression evaluation. • Proof of concept generation on rare disease mRNA targets.
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Contract ResearcherMerrimack Pharmaceuticals Jun 2011 - Nov 2011Cambridge, Ma• Successfully affinity matured an anti-EGFR single chain variable fragment (scFv) using a yeast library display system. • Ongoing application of flow cytometry and immunology expertise to optimize processes within the Merrimack Antibody Technology Team. -
Senior Preclinical Associate ITolerx Nov 2007 - Apr 2011Cambridge, Massachusetts, United States• Instrumental in demonstrating that otelixizumab differentially regulates human T Regulatory and non T Regulatory T cell subsets.• Planned and executed all cellular assays pertaining to the anti-CD3 antibody program including mixed lymphocyte reaction, flow cytometry acquisition, cell sorting, and phosphoflow to further investigate and characterize the in vitro immunoregulatory properties of the company’s lead drug candidate.• Completed the majority of experiments related to the characterization of the immunoregulatory properties of anti-ILT (Ig-Like Transcript) antibodies. -
In Vitro SupervisorToxikon Corporation Nov 2005 - Oct 2007Bedford, Massachusetts, United States• Performed an extensive variety of cell culture, cytotoxicity, hematology and genetic toxicology assays in a GLP setting.• Ensured GLP and ISO compliance of the lab.
Justin Guild Skills
Justin Guild Education Details
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Biotechnology -
Bioinformatics
Frequently Asked Questions about Justin Guild
What company does Justin Guild work for?
Justin Guild works for Undisclosed
What is Justin Guild's role at the current company?
Justin Guild's current role is Scientist.
What is Justin Guild's email address?
Justin Guild's email address is ju****@****ail.com
What schools did Justin Guild attend?
Justin Guild attended Harvard University, Western University.
What skills is Justin Guild known for?
Justin Guild has skills like Assay Development, Elisa, Cell Culture, Flow Cytometry, Immunology, Drug Discovery, Molecular Biology, Biotechnology, In Vitro, Tissue Culture, Glp, Western Blotting.
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Justin Guild
Experience In Inventory And Warehouse Management; Driven For Process Improvement With A Focus On Management And Training Of The WorkforceWichita, Ks1bestbuy.com -
Justin Guild
Managing Member - Property Manager At Daytona Realty And Property Management, Llc.Daytona Beach, Fl -
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