-Synthesis and evaluation of linker-payload constructs with novel mechanisms of action for ADCs.-Synthesis of pro-drug technologies for delivery of impermeable drugs.-High level presentations and advocacy to executive leadership for advancement of novel payloads for ADCs.

-Synthesis and conjugation of NAMPT inhibitor linker-payload constructs to antibodies to form antibody-drug conjugates (ADCs).-Optimization and execution of biochemical assays to evaluate NAMPT inhibition.-Synthesis and evaluation of linker-payload constructs targeting novel mechanisms of action with ADC delivery.

-Synthesis and evaluation of carbohydrate linkers for antibody-drug conjugates (ADCs).-Synthesis and evaluation of multiple scaffolds of inhibitors of nicotinamide phosphoribosyltransferase (NAMPT), and evaluation as payloads in ADCs.-Synthesis of alternate linker technologies for attachment and release of payloads in ADCs.

- Synthesis (by solution and solid phase) of heterocyclic small molecule inhibitors of Gram-negative bacterial secretion systems and bacterial signaling.- Synthesis of bi- and tri-functional crosslinkers for chemical proteomics, including natural product derived affinity probes for target identification.- Synthesis of alkylindole derivatives for novel cannabinoid receptors in CB1/CB2 negative cells. - Total synthesis of two monophosphoryl lipid A structures from P. Gingivali, 21 steps each starting from glucosamine.- Synthesis of transition state inhibitors for 2-component regulatory systems.

-Analysis of patient steroid hormone profiles involving solid phase extraction, enzyme hydrolysis, chemical derivitization, and analysis by GC/MS.

- Synthesis of heterocyclic anti-cancer enzyme inhibitors targeting lysophosphatidic acid acyl transferase beta (LPAATb).- Management and formulation of compound libraries for in vitro assays and high-throughput screening.- Administration of chemical databases and creation of templates for data capture and analysis.- Development of robust HTS assays for successful screening campaigns against anti-cancer targets.

-Synthesis of a receptor for inositol 1,4,5-triphosphate. -NMR binding equilibrium studies and molecular modeling studies.