Keith Everett Email & Phone Number

Pittsboro, Nc

Designed, developed, and implemented 2 successful plant-based bio-pharmaceutical production systems; one being reusable and based on clean-in-place technology; and the other being based entirely on our proprietary single-use technologies. These upstream process projects were designed to provide a scalable pharmaceutical-grade manufacturing system for application to a highly productive, epipelagic, aquatic plant culture (Lemna minor). I acted as team lead for the group that created and tested all upstream designs including those related to MPB, bioproduction, scale-up, culturing, harvest and biomass sequestration. Directed the development of the industrialized version conforming to GMP and USP requirements and assisted with QA guideline development/implementation. These designs now include issued patents and patent applications currently in process. (For a full description of the SU process, see the publication listing below.) This particular project and its side projects were engaging; more so due to the inherent complexity and the lack of any prior art or comparable systems. Once the development projects were successfully completed, I then provided SME assistance, further scale-up design and integration consulting for the GMP installation.

Responsible for creation of a novel automated plant based high-throughput screening system based on a modified TECAN liquid handler platform. Created a novel automated plant growth maintenance system used for screening and propagating the plant-based (Lemna sp.) production platform. Modified and programmed liquid handlers for use in asymmetric processes for non-standard applications as required for the Lemna sp. platform. Designed additional hardware not available OTS--as well, I was responsible for the conception, design, and fabrication of preliminary upstream production prototypes. Served as a member of the Biolex Executive Committee.

Directed 12 engineers and was directly responsible for GMP compliance of analytical and development instrumentation for all RTP campuses in and around the Moore Drive Facility. Consulted on R&D automation projects and process design projects. Conceived, developed, and implemented tech transfer education program, HPLC operation techniques course, electronics basics for technical resources.

Created and operated a private consulting firm primary assisting government and private laboratories with automation and equipment related issues. Consulted as an instrument broker and a process design consultant. Intellectual Property and Publications Issued Patents (does not include foreign patents):

Durham, Nc

Co-lecturer for a business ethics course addressing ethics and morality in technologically complex world.

Set up and operated a university wide core facility providing analytical and prepartive HPLC services, DNA/RNA oligonucleotide synthesis services, instrumentation engineering, fluorescent spectroscopy, Scientific illustration.