Kelsey Lynch Email & Phone Number

Seattle, Wa, Us

Seattle, Washington, United States

Seattle, Washington, United States

Greater Seattle Area

I implemented studies in budding yeast and human cells to reveal that adenoviruses exploit the antagonism between two families of chromatin factors, linker histones and HMGB proteins, to dysregulate host cell cycle progression likely benefitting viral replication. Mentored by Daphne Avgousti, Ph.D. My work is currently in press at Current Biology-- see link to Biorxiv preprint.Accomplishments:- First author publication of research project that is in press at Current Biology- First author publication of review article at FEBS Letters exploring the relationship between adenovirus infection and host chromatin (see link)- Invited speaker for Fragile Nucleosome online seminar series focused on epigenetics and chromatin biology- Obtained funding through competitive training grant- Adapted new techniques for the lab such as next-gen sequencing library prep, ChIP-seq, budding yeast strain engineering and genetics experiments, soft agar colony formation assay, and flow cytometry- Developed standard lab protocols for adenovirus purification and titering- Extensive mentorship of undergraduate students, research technicians, and graduate students

Seattle, Washington, United States

I studied the effects of limiting DNA replication protein abundance on timing of DNA replication and genome stability in the model eukaryote Saccharomyces cerevisiae resulting in first author publication at PLoS Genetics (see below). Mentored by Bonny Brewer, Ph.D., and M.K. Raghuraman, Ph.D.Accomplishments: - First author publication at PLoS Genetics (see link): "The effects of manipulating levels of replication initiation factors on origin firing efficiency in yeast" - Obtained funding through competitive training grant - Presented research at Cold Spring Harbor Laboratories Eukaryotic DNA Replication & Genome Maintenance Meeting (2015 & 2017) and FASEB Yeast Chromosome Structure, Replication, and Segregation Conference (2016) - Mastered a wide range of molecular biology methods such as DNA purification, molecular cloning, yeast strain engineering, genome-wide DNA replication assays, Southern blotting, and pulsed-field gel electrophoresis - Nominee for UW Graduate School Medal for "academic expertise and social awareness [demonstrating] active civic engagement and a capacity to promote political, cultural and social change"

Carried out independent research project on the role of heterochromatin maintenance in genome stability in the model eukaryote Neurospora crassa. Managed lab organization, trained incoming lab members, and mentored undergraduate student worker. Mentored by Dr. Zachary Lewis, Ph.D. Accomplishments: - Second author publication at Eukaryotic Cell (see link)Accomplishments: - Second author publication at Eukaryotic Cell (PMID: 24879124): "Heterochromatin Controls γH2A Localization in Neurospora crassa"

Eugene, Oregon, United States

I was a summer research intern in the lab of Eric Selker at the University of Oregon Institute of Molecular Biology. I studied DNA methylation and heterochromatin maintenance in the model organism Neurospora crassa. I applied for and was granted competitive HHMI funding to support this research experience.

Doctor Of Philosophy - Phd, Molecular And Cellular Biology

Activities and Societies: UW Undergraduate Research Mentor, PAWS on Science volunteer, Seattle Expanding Your Horizons Planning Committee.

Bachelor Of Arts (B.A.)

Activities and Societies: HHMI Science Horizons Summer Undergraduate Research Fellowship (2010), Peer tutor for Bryn Mawr Deans Office.