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Kevin Walsh is listed as Director, Immunology at BreezeBio, based in San Francisco Bay Area, United States. AeroLeads shows a matched LinkedIn profile for Kevin Walsh.
Kevin Walsh previously worked as Director, Immunology at Genedit and Senior Principal Scientist at Genentech. Kevin Walsh holds Doctor Of Philosophy, Biological Sciences from University Of California, Irvine.
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About Kevin Walsh
Background: Cancer Immunology, Viral Immunobiology, Cell BiologyResearch & Development: Biological insights from my lab spawned 4 pipeline programs which I was team lead of 3. My target discovery and validation efforts established 1 pipeline program where I served as team lead and several other pre-early-stage research programs. I developed T cell-based functional assays including HTP screening platforms currently being used to support multiple pipeline programs.Management: I have served as program team lead, biology lead or as a member for multiple programs at varying stages in pipeline development. All program teams were cross-functional groups which I effectively organized and worked across to move projects forward or terminate them based on biological or clinical development rationale. I acted as team lead for a small molecule business development opportunity that we declined based on strong data under my leadership. I run a successful lab of up to 5 individuals where we perform discovery, target validation and mechanistic studies for pipeline programs. The main goals of my lab are: 1) Identify/validate novel targets, 2) Obtain mechanistic insights into targets/therapeutics & 3) Support outside programs where possible to improve path to success.Leadership: I believe that a leader is only as good as their team and a team is only as good as their leader. It is a reciprocal relationship that requires respect, trust and integrity. A leader needs to provide direction, delegate appropriately and utilize resources efficiently. More importantly, a leader needs to listen to their team members, take their suggestions to heart and pivot pending sound rationale. For all of my program teams we have performed critical experiments when the appropriate tools/assays were available to either move the program forward or deprioritize it. All pertinent data is compiled and presented to the team including recommendations based on the data and the decision are made as a unit. Empowering your team, encouraging them to provide their suggestions as well as incorporating their ideas on the direction of the program creates a strong team that is more contiguous and efficient. Lastly, leading by example through hard-work, dedication, initiative and integrity is critical to effective leadership and what I strive for on a daily basis.
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7 roles
Kevin Walsh work experience
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Director, Immunology
Senior Principal Scientist
Senior Principal Scientist in the department of Oncology. For the past 8 years I have worked on synthetic immunity, specifically bispecifics. The biological insights from my laboratory spawned initiation of 4 bispecific programs in which I served as team lead on 3 of them. My laboratory also performed validation on numerous other targets, both co-stimulatory and tumor antigen targets, which resulted in agonist antibody programs where I served as team lead with several pre-early-stage research programs ongoing. All program teams were cross-functional groups which I effectively organized and worked across to move projects forward or terminate them based on biological or clinical development rationale. I also run a successful laboratory of up to 5 individuals where we perform most of the discovery, target validation and mechanistic studies. I have also focused on hypertension and aspects of cancer immunology such as the effects of VEGF and myeloid cells as well as mechanisms of activity and resistance to bispecifics. These efforts have resulted in 6 peer-reviewed publication with 1 in preparation. I also focused efforts on novel and innovative techniques to assess immune cell function. Assays developed by my laboratory have been utilized by multiple other program teams at Genentech to perform HTP identification and validation of candidates. I have also explored the effects of cytokines on augmenting T cell bispecific responses. A cytokine that could enhance bispecific response without exacerbating cytokine storm was identified and I serve as biology lead for this specific program.
Postdoctoral Fellow
Postdoctoral fellowship in the laboratory of Michael B. A. Oldstone. Mechanistic understanding of virus-induced cytokine release syndrome & therapeutic prevention utilizing sphingosine analogues with a focus on influenza virus (mouse adapted & H1N1) & paramyxovirus (pneumonia virus of mice). Treatment significantly improved host outcome highlighting the potential therapeutic implementation of S1P receptor based drugs for human viral-induced pathology.Regulation of chronic viral infection & T cell dysfunction utilizing lymphocytic choriomeningitis virus (LCMV). Determined that TLR7 signaling is required for control of chronic LCMV infection.Postdoctoral work resulted in 17 publications.
Jan 2008 - Jun 2012
Graduate Student
Graduate student in the laboratory of Tom Lane. Thesis: The protective roles of CXCL10 and NKG2D during murine coronavirus infection of the central nervous system and liver.Assessed the protective role of chemokine CXC ligand 10 in murine coronavirus (mouse hepatits virus, MHV) infection of the central nervous system (CNS) and liver. Determined the requirement of CXC ligand 10 for the recruitment of lymphocytes into the CNS that provided insight into the pathogenesis of human CNS diseases.Identified the functional role of the immunoreceptor NKG2D on T cells in the CNS following murine coronavirus (MHV) infection. Determined that optimal cytoxic T cell activity in the CNS requires NKG2D signaling highlighting a novel mechanism for such cells in viral CNS disease.Determined the effects of NKG2D signaling on NK cells during murine coronavirus (MHV) infection of the liver. Graduate student work resulted in 6 publications.
Aug 2002 - Sep 2007
Research Associate
Sugen, Inc
Identified novel kinases associated with cancer for development of small molecule kinase inhibitors. Cloned and validated novel kinases to identify potential therapeutic targets. Evaluated the oncogenic potential of novel kinases.
Feb 2001 - Aug 2002
Summer Internship
Sugen, Inc
Cloned and sequenced novel kinases.
Jun 2000 - Aug 2000
3 education records
Kevin Walsh education
Doctor Of Philosophy, Biological Sciences
Bachelor Of Science, Biochemistry
Bachelor Of Arts, Chemistry
FAQ
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What company does Kevin Walsh work for?
Kevin Walsh works for BreezeBio.
What is Kevin Walsh's role at BreezeBio?
Kevin Walsh is listed as Director, Immunology at BreezeBio.
Where is Kevin Walsh based?
Kevin Walsh is based in San Francisco Bay Area, United States while working with BreezeBio.
What companies has Kevin Walsh worked for?
Kevin Walsh has worked for Breezebio, Genedit, Genentech, Scripps Research, and Uc Irvine.
How can I contact Kevin Walsh?
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What schools did Kevin Walsh attend?
Kevin Walsh holds Doctor Of Philosophy, Biological Sciences from University Of California, Irvine.
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