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A thought-provoking drug discovery professional who leads integrated projects through the different stages of pre-clinical development from target identification to candidate nomination. Combines strong analytical and problem-solving skills with expertise in chemical biology, genetics and proteomics to identify and validate novel targets for the treatment of autoimmune and inflammatory diseases, which are increasingly exploited in immuno-oncology. Effectively converts this knowledge into screening cascades and pharmacodynamic biomarkers to drive the development of clinical candidates. Closely involved with the delivery of two candidate molecules in the (immuno)oncology space with one currently in phase I clinical trials. A highly effective mentor with a proven ability to develop high performing individuals and teams as well as internal and external networks that operate collaboratively to deliver project results within agreed timelines and budgets. Passionate about working in an innovative environment at the interface between academia, biotech and pharmaceutical industries and thereby contributing to the next generation of therapeutics.
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Head Of BiologyGreywolf TherapeuticsNottingham, Gb -
Head Of BiologyGreywolf Therapeutics Mar 2023 - PresentMilton, Oxfordshire, Gb -
Director Of Kinase BiologyExscientia Sep 2021 - Feb 2023Oxford, Oxfordshire, Gb -
Principal ScientistSygnature Discovery Apr 2019 - Sep 2021Nottingham, Gb•Leader of 11-12 FTEs in a matrix management system (7 FTEs line management + 4-5 FTEs project team)•Lead Bioscientist and Deputy Project Leader on integrated drug discovery projects with oversight on internal and outsourced activities•Supported the development of two pre-clinical candidates; one now in phase I clinical trials and the other going through final stages of pre-clinical development•Successfully worked across different therapeutic areas (immuno-oncology, neuroscience) and target classes (kinases, proteases, metabolic enzymes)•Delivered bespoke biochemical, cellular assays and PD biomarkers, including complex co-culture assays for immuno-oncology targets, within agreed budget and timelines•Presented outcome of partnership at international conference and contributed key data to several posters presented at meetings such as AACR and SITC•Built strong relationships with clients to influence direction of the research project with an overall benefit to client and company•Led technical interviews during candidate selection•Authored key opinion blog on target identification and target validation -
Senior ScientistSygnature Discovery Feb 2016 - Apr 2019Nottingham, Gb
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Independent InvestigatorMrc Protein Phosphorylation And Ubiquitylation Unit, University Of Dundee May 2014 - Jan 2016Dundee, Gb•Led a team of young scientists whose goal was to dissect signalling pathways in innate immunity and identify novel strategies for treating autoimmune and inflammatory diseases. -
Senior Postdoctoral FellowMrc Protein Phosphorylation And Ubiquitylation Unit, University Of Dundee May 2009 - May 2014Dundee, Angus, Gb•Discovered that inhibition of Salt-Inducible Kinases induces an anti-inflammatory gene signature in macrophages and represents a novel strategy for treating inflammation. (co-inventor on patent)•Mapped the signalling pathways regulating TBK1/IKKi activation in innate immunity. •Identified novel cell-based biomarkers for TBK1/IKKi activity using chemical biology and phosphoproteomics methodologies. •Supported our partners in the pharmaceutical industry on projects to validate key drug targets. -
Embo Long-Term FellowMrc Protein Phosphorylation And Ubiquitylation Unit, University Of Dundee 2007 - 2009•Identified the first potent pharmacological inhibitor suitable for studying TBK1 and IKKi function in mammalian cells. •Developed, in collaboration with the biotech industry, a second generation inhibitor of TBK1 and IKKi. •Used these inhibitors to dissect the molecular mechanisms regulating TBK1 and IKKi activation in innate immunity and to assess TBK1 and IKKi as targets for treating cancer.
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Junior ResearcherNcmls, Radboud University Nijmegen, The Netherlands 2002 - 2007PhD Dissertation: TRPM7, a novel regulator of the actomyosin cytoskeleton. •Investigated the role of TRPM7 in cancer cell adhesion and migration using molecular and cellular biology.•Defined the TRPM7 interactome by mass spectrometry leading to the identification of a novel diagnostic signature for cancer progression.
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Research TechnicianNetherlands Cancer Institute (Nki) Apr 2001 - Jul 2002Amsterdam, Noord Holland, Nl•Assisted scientists in projects aimed at defining the role of Tiam1 in mouse models of cancer.
Kris Clark Skills
Kris Clark Education Details
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Radboud University Nijmegen, NetherlandsMedical Sciences -
Jcsmr, Australian National University, AustraliaMedical Sciences
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Université De Montréal, CanadaMolecular Biology
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Concordia University, CanadaChemistry/ Biochemistry
Frequently Asked Questions about Kris Clark
What company does Kris Clark work for?
Kris Clark works for Greywolf Therapeutics
What is Kris Clark's role at the current company?
Kris Clark's current role is Head of Biology.
What is Kris Clark's email address?
Kris Clark's email address is kc****@****a.co.uk
What is Kris Clark's direct phone number?
Kris Clark's direct phone number is +44 1382 3*****
What schools did Kris Clark attend?
Kris Clark attended Radboud University Nijmegen, Netherlands, Jcsmr, Australian National University, Australia, Université De Montréal, Canada, Concordia University, Canada.
What skills is Kris Clark known for?
Kris Clark has skills like Molecular Biology, Cell Biology, Cell Culture, Cell Signaling, Biochemistry, Protein Expression, Western Blotting, Immunology, Qpcr, Innate Immunity, Phosphoproteomics, Enzymology.
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