AeroLeads people directory · profile
Kyle Simonetta, Ph.D. Email & Phone Number
SVP, Research
at
Site Therapeutics
1 work email found
@interlinetx.com
LinkedIn matched
✓ Verified August 2026
4 data sources
Profile completeness 100%
Current company
Role
SVP, Research
Location
South San Francisco, California, United States
Company size
Who is Kyle Simonetta, Ph.D.? Overview
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Quick answer
Kyle Simonetta, Ph.D. is listed as SVP, Research at Site Therapeutics, a with 15 employees, based in South San Francisco, California, United States. AeroLeads shows a work email signal at interlinetx.com and a matched LinkedIn profile for Kyle Simonetta, Ph.D..
Kyle Simonetta, Ph.D. previously worked as Vice President, Research at Site Therapeutics and Senior Director, Lead Discovery at Interline Therapeutics. Kyle Simonetta, Ph.D. holds Ph.D., Molecular And Cell Biology from University Of California, Berkeley.
Company email context
Email format at Site Therapeutics
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*@interlinetx.com
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AeroLeads found 1 current-domain work email signal for Kyle Simonetta, Ph.D.. Compare company email patterns before reaching out.
Profile bio
About Kyle Simonetta, Ph.D.
-Highly motivated and creative drug discovery leader with 12 years of industry experience and expertise in using biochemistry, biophysics, and structural biology to drive discovery, characterization, and development of small molecules through screening and structure-based drug design campaigns-Proven track record in the discovery and development of small molecules that modulate protein-protein interaction (inhibitors and molecular glues) as well as targeted degraders (PROTACs)-Project leader with experience driving programs from inception through hit identification, hit-to-lead progression, cellular proof-of-concept, and in vivo lead optimization-Group leader guiding early drug discovery activities across internal and partnered programs, including biochemical/enzymatic/HTS assay development, biophysics, and structural biology
Listed skills include Molecular Biology, Protein Purification, X Ray Crystallography, Biochemistry, and 13 others.
Current workplace
Kyle Simonetta, Ph.D.'s current company
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8 roles
Kyle Simonetta, Ph.D. work experience
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Vice President, Research
Current
May 2024 - Present
Senior Director, Lead Discovery
Oct 2021 - Mar 2024
Director, Lead Discovery
Apr 2021 - Sep 2021
Director, Lead Discovery
Aug 2019 - Mar 2021
Associate Director, Lead Discovery
Project lead on programs aimed at drugging E3 ubiquitin ligases, including the first prospective discovery of molecular glue small molecules that enhance the interaction between an E3 ligase and its substrate. We employed high-throughput screening and structure-based drug design to identify and optimize small molecules that bind at the protein-protein interface of the E3 ligase ß-TrCP and its substrate ß-Catenin, improving the binding affinity of degradation resistant ß-Catenin for ß-TrCP over 1500-fold, causing its ubiquitylation and degradation. This approach of restoring degradative function by identifying molecular glue that enhances protein-protein interactions disrupted in disease is complementary to the bifunctional PROTAC approach of induced protein degradation and can be applied to many other difficult-to-drug disease targets.Project leadership and support for various lead discovery programs through: • Target identification and validation• Protein design and purification• Fluorescence-based protein-protein interaction assay development• Biophysical assay development• Enzymatic (ubiquitylation) assay development• High-throughput screening• X-ray crystallography (crystal growth, data collection, structure solution, model building)• Cellular target engagement assay development• Close collaboration and communication with medicinal and computational chemistry
Mar 2012 - Aug 2019
Postdoctoral Scientist
Advisor: Michael Rape, Ph.D.- Used biochemical assays and high-throughput screening methodologies to investigate the druggability of E3 ubiquitin ligases
Mar 2010 - Mar 2012
Senior Laboratory Technician
Jul 2002 - Jul 2004
2 education records
Kyle Simonetta, Ph.D. education
Ph.D., Molecular And Cell Biology
University Of California, Berkeley
B.A., Biophysical Chemistry
Dartmouth College
FAQ
Frequently asked questions about Kyle Simonetta, Ph.D.
Quick answers generated from the profile data available on this page.
What company does Kyle Simonetta, Ph.D. work for?
Kyle Simonetta, Ph.D. works for Site Therapeutics.
What is Kyle Simonetta, Ph.D.'s role at Site Therapeutics?
Kyle Simonetta, Ph.D. is listed as SVP, Research at Site Therapeutics.
What is Kyle Simonetta, Ph.D.'s email address?
AeroLeads has found 1 work email signal at @interlinetx.com for Kyle Simonetta, Ph.D. at Site Therapeutics.
Where is Kyle Simonetta, Ph.D. based?
Kyle Simonetta, Ph.D. is based in South San Francisco, California, United States while working with Site Therapeutics.
What companies has Kyle Simonetta, Ph.D. worked for?
Kyle Simonetta, Ph.D. has worked for Site Therapeutics, Interline Therapeutics, Nurix Therapeutics, Uc Berkeley, and Columbia University.
How can I contact Kyle Simonetta, Ph.D.?
You can use AeroLeads to view verified contact signals for Kyle Simonetta, Ph.D. at Site Therapeutics, including work email, phone, and LinkedIn data when available.
What schools did Kyle Simonetta, Ph.D. attend?
Kyle Simonetta, Ph.D. holds Ph.D., Molecular And Cell Biology from University Of California, Berkeley.
What skills is Kyle Simonetta, Ph.D. known for?
Kyle Simonetta, Ph.D. is listed with skills including Molecular Biology, Protein Purification, X Ray Crystallography, Biochemistry, Cell Biology, Protein Chemistry, Pcr, and Protein Expression.
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