Lars Engstrom Email & Phone Number

San Diego, CA, US

San Diego, California, United States

Biology lead for the MTA-cooperative PRMT5 pharmacology team, overseeing studies to advance the program from target validation to IND submission. MRTX1719 (BMS-986504) is a potential best-in-class precision medicine for MTAP-deleted cancers, leveraging the concept of synthetic lethality.Expanded Mirati's research capabilities by leading translational.

In vitro assay development and data generation for PF-02341066 (crizotinib / Xalkori) NDA and sNDA study reports demonstrating potency in pALK and pROS1 ELISA assays, as well as viability and apoptosis assays.Engineered cell lines with secondary resistance mutations to first- and second-generation ALK inhibitors and developed cell-based assays, leading to.

Developed imaging methods to quantify hepatic endothelial cell proliferation in rats. Results were included in a follow-up data package to address FDA toxicology inquiries, facilitating the approval of CI-1008 (pregabalin/Lyrica). Provided expertise in epifluorescence and confocal imaging to create automated capture and analysis assays for toxicology.

Characterized DNA binding and protein interactions of an alternatively spliced Mxi isoform involved in the Myc/Max/Mad network. Managed laboratory operations, researched new instruments for purchase, assisted in manuscript and grant writing, and supervised and trained technicians, research fellows, post-doctoral researchers, undergraduate students, and.

Bachelor Of Science (Bs)

Biology, Economics

Activities and Societies: Varsity Soccer