Lauren Yarrow-Wright Ph.D Mchem Pgce Email & Phone Number

6 month secondment to the organic and chemical biology team - worked on Organic & Biomolecular Chemistry, Molecular Omics, Natural Product Reports and RSC Medicinal Chemistry journals.

I currently teach A Level chemistry at Barton Peveril Sixth Form College. I teach OCR A but have taught AQA during my PGCE.

Leeds, United Kingdom

Leeds, United Kingdom

Supervised by Professor Joanne Tipper, Dr Sophie Williams and Dr Eric Hewitt.Part of the EPSRC-funded White Rose consortium DTC between the Universities of Leeds, Sheffield and York.Thousands of total hip replacements are performed every year; the current gold standard hip prosthesis is metal on polyethylene which is successful in the majority of patients. However, ultra-high molecular weight polyethylene (UHMWPE) produces the highest volume of wear debris compared to metal and ceramic implants, which causes osteolysis and aseptic loosening (the cause of 50% of all revision surgeries). UHMWPE can be radiatively cross-linked to reduce the volume of wear debris produced. However, irradiation creates free radicals which can cause oxidative damage to the material. Antioxidants can be added which directly interact with free radicals and prevent structural damage. Antioxidant doped cross-linked UHMWPE, in particular with vitamin E, also appears to exhibit anti-inflammatory properties which could reduce the incidence of osteolysis in vivo. My project aims to investigate vitamin E and hindered phenol doped highly cross-linked UHMWPEs to establish whether osteolysis can be reduced through the anti-inflammatory effect of such materials. I produce clinically relevant UHMWPE wear debris using single and six station wear simulators and study the cellular response to the particles generated by probing inflammatory and oxidative damage pathways.

Leeds, United Kingdom

I was part of a team who provided a public engagement stall at the Great Yorkshire Show 2015 on behalf of the Institute of Medical and Biological Engineering. We spoke to people of all ages and backgrounds about our work - in my case, primarily joint replacements - and provided activities such as make your own neuron.I have also helped to run similar activities at the Otley Science Fair.

Leeds, United Kingdom

Leeds, United Kingdom

Leeds, United Kingdom

Supervised by Louise Crabtree.As a STEM education outreach fellow, I work with the chemistry department to design and deliver chemistry workshops and activities to schools and students of all ages either on site at the university or out in schools.

Leeds, United Kingdom

I was an occasional tutor on the first year medics course - introduction to medical sciences. I provided classroom assistance on immunology, neurology and musculoskeletal workshops.

Leeds, United Kingdom

I was a demonstrator on the first year biochemistry practical module - I looked after two benches (16 students); regularly assisting with practical procedures, such as UV-vis spectroscopy and plate reading, and marking lab books and reports.

Leeds, United Kingdom

York, United Kingdom

Supervised by Professor Anthony Wilkinson and Dr Jim Brannigan.This project endeavoured to structurally resolve malarial N-myristoyltransferase (NMT) from the strain, Plasmodium falciparum (Pf). NMT catalyses the transfer of 14 carbon fatty acid, myristate, onto proteins; both post- and co-translationally. It is important for membrane affinity and proliferation/apoptosis therefore providing a potential drug target through its inhibition. During this project, I used recombinant techniques such as site directed mutagenesis and overexpression (in E-Coli), isolation and purification techniques such as affinity chromatography.

York, United Kingdom

York, United Kingdom

Leeds, United Kingdom

Wakefield, United Kingdom

Leeds, United Kingdom

Wakefield, United Kingdom

Pgce, Science

I chose to specialise in chemistry during my PGCE in science. I taught at 3 different secondary schools throughout the year (The Forest.

Doctor Of Philosophy (Ph.D.), Tissue Engineering And Regenerative Medicine

Activities and Societies: Demonstrating, Invigilating, Outreach, Public engagement, Professional development I was attracted to the DTC.

Master Of Chemistry, Chemistry, 2:1

Throughout my chemistry degree, I developed a keen interest in applying my chemistry knowledge to medical, biological and environmental.

Languages For All Programme, Spanish - Level 2, 3 And 4, Distinction/Merit/Pass Respectively

During my undergraduate studies, I continued to improve my Spanish language skills - I began with level 2 as I already had GCSE level.

A-Levels, Biology, Chemistry, General Studies, Geology, Mathematics, B,B,B,A,A

Activities and Societies: Yoga, Karate, Running I chose subjects that would lead me down a scientific path at college. I was particularly.

Key Skills, Information Technology And Communication Skills & Application Of Number, Level 3 - Pass

High School, Gcse'S: 12, 7 A*'S, 3 A'S And 2 B'S

Activities and Societies: Cross country/track running, Netball GCSE's taken: Double science award (A*A*), Maths (A*), English language.