Sally Lee-Sayer Email & Phone Number

Vancouver, British Columbia, Canada

Vancouver, British Columbia, Canada

• Led R&D initiatives and antibody discovery programs (4), demonstrating adept project management skills• Provided support on immunization campaigns for the antibody discovery pipeline (10+ programs), utilizing knowledge and learnings in immunization strategies, and skills in coordination to liaise between stakeholders• Successfully executed various hands-on animal procedures for immunization campaigns (anesthesia, intradermal injection, saphenous vein blood and cardiac bleed collection)• Developed and performed target-specific titre testing and single cell screening assays to identify cells that secrete antibodies with desired properties• Managed a functional group, overseeing workflow infrastructure, providing training, and ensuring deliverables met target deadlines• Established and maintained productive relationships with a new Contract Research Organization (CRO), and contributed to feasibility evaluations of CRO to ensure project alignment with organizational goals• Contributed to the validation of novel immunization strategies• Successfully implemented new workflows and standard operating procedures (SOPs) for RNA-LNP production and quality control, and the technology demonstrated promise as an immunization strategy that aligns with company goals• Contributed to design and ordering of DNA vectors used for immunization and cell line generation, and provided support for vector QC and troubleshooting • Involved in training team members, including 2 direct reports (research technicians), fostering skill development and team growth• Prepared proposals and reports of experimental designs and results, and presented to external collaborators, global site team membersSkillsImmunization Strategies · Flow Cytometry · Cell Based Assays · Cell Culture · Program Execution · Cross-Functional Collaboration · Animal Procedures · Tissue Collection

Burnaby, British Columbia, Canada

• Spearheaded the design and coordination of preclinical rodent efficacy studies for one major program, demonstrating expertise in project management and CRO liaison• Developed and executed innovative assays, including multicolor flow cytometry for T cell response analysis and ELISA for evaluating target-specific sera titres• Directly contributed data package that enabled program progression to Phase I clinical trials, underlining a direct impact on project advancement and success• Actively involved in expanding the research pipeline through comprehensive literature research on novel targets and platform applications across various disease indications• Contributed to the progression of four novel targets to R&D and pre-clinical evaluation, highlighting a significant impact on research direction and organizational growth• Prepared and presented insightful proposals to team members and stakeholders, showcasing strong communication and analytical skills• Developed and executed SOP for analysis of clinical samples to profile the systemic immunological effects of the drug product while maintain appropriate clinical documentation• Participated in cross-disciplinary planning and experimental designs for internal projects and external collaboration, and provide immunological expertise• Interviewed for and managed two direct reports (co-op students) - web lab technique and scientific training, priority management for reports - received great feedback for mentorship and both students are pursuing careers in scene• Provided relevant training and mentorship to other junior team members when applicable - project proposal and literature review, web lab technique training, experimental troubleshootingSkills:Immune Profiling · Preclinical Animal Studies · Flow Cytometry · Assay Development · Molecular Biology · Program Execution · Project Management · Literature Research · Industry Collaboration

Vancouver, British Columbia, Canada

Vancouver, British Columbia, Canada

Supervisor: Dr. Pauline Johnson• Evaluated immune cell functions in vivo using diverse mouse models, including bone marrow transplant, adoptive T cell transfer, and infectious disease models• Demonstrated skills in various mouse techniques and procedures, including intravenous (IV; recognized for high proficiency by peers and animal technicians), intratracheal (IT), and intraperitoneal (IP) injections, anesthesia administration, terminal cardiac bleed collection, and working in a CL2 containment• Designed and conducted in vitro immunological and cell-based assays to investigate primary immune cell functions and mechanisms of function using multicolor flow cytometry, MSD (mesoscale discovery) platform, ELISA, T cell proliferation assay, Treg suppression assay, cell cycle analysis• Characterized immune populations from various tissues using multi-colour flow cytometry - cell surface labeling, intracellular labeling• Isolated primary immune cells from lymphoid (bone marrow, spleen, lymph nodes) and nonlymphoid (liver and lung) tissues and blood using magnetic enrichment or fluorescence-assisted cell sorting (FACS) for culturing, cell-based assays, and flow analysis • Evaluated and optimized retroviral transduction and transfection (lipofectamine and electroporation) protocols for primary hematopoietic cells and cell lines• Provided scientific mentorship to lab members• Participated in collaborative projects with other labs• Established and maintained lab organization, including meetings schedules, digital resources, and protocols• Participated in collaborative projects with other labs• Provided training and direct supervision of several undergraduate and junior graduate students• Scheduled and presented in weekly lab meetings and journal clubsSkills:Animal Studies · Flow Cytometry · Cell-Based Assays · Assay Development · Literature Research · ELISA · Research Collaboration

Doctor Of Philosophy - Phd, Immunology

Supervisor: Dr. Pauline Johnson Dissertation: Hyaluronan binding and CD44 in regulating haematopoiesis and CD8 T cell response.

Bachelor Of Science - Bs, Microbiology And Immunology

Research Supervisor: Dr. Franck Duong Undergraduate Dissertation: ATPase activity characterization of the Escherichia coli flippase MsbA.