Leonardo Sanchez Solis Email & Phone Number

San Diego, California, United States

• Spearheaded the creation of a novel machine learning model for automated endoscopy, enhancing clinical endpoint quality and treatment prediction in IBD and colorectal cancer
• Integrated spatial and single-cell transcriptomics to identify novel tumor microenvironments across 3 cancer types and over 2500 patients; performed spatial analysis in a murine model to investigate immune system.
• Generated a prostate cancer-specific epigenetic atlas with over 3000 samples, 30 cell lines, and 30 unique antigens using parallel computing, accelerating target discovery, biomarker identification, and predictive.
• Developed cellular-based assays to assess histone modifications and downstream immune signaling cascades, advancing tumor immunogenicity biomarker screening and enriching exploratory biology research on transcriptional.

Houston, Texas Area

• Employed CRISPR activation technologies in mesenchymal stem cell immunoengineering to modulate stimulus-responsive transcription factors; characterized activation mechanisms using RNAseq and multi-dimensional image.
• Investigated immune cell interactions with biomaterials, optimizing time-lapse microscopy for dynamic monitoring of immune cell taxis
• Advanced cryopreservation techniques for microencapsulated therapeutic secreting cells by establishing imaging criteria for post-cryopreservation cell viability assessment and devising novel scoring methods for capsule.
• Designed a DNA-based plasmid library for targeted protein expression in mammalian cells, fine-tuning steady-state gene expression to develop more accurate in-vitro disease models

• Acquired essential skills in microbiology and synthetic biology, laying the groundwork for future intensive research projects.
• Interacted with faculty mentors and fellow REU participants, enhancing understanding of biomolecular dynamics and the nature of academic research