Liam Chase

Liam Chase Email and Phone Number

PhD in Bioengineering Student at University of Pennsylvania
Liam Chase's Location
Philadelphia, Pennsylvania, United States, United States
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About Liam Chase

Experienced medical research scientist with a demonstrated history of working in the higher education industry and private industry.Current student for a PhD in Bioengineering from University of Pennsylvania.Strong research professional with a Bachelor of Science in Bioengineering focused in Bioengineering and Chemistry. Skilled in workflow management, nanomedicine, pharmacology, mouse work, tissue Engineering, engineering design, public speaking, and electrohydrodynamic atomization. Background in:Collaborating with a pharmaceutical company to develop nanomedicine-based therapeutics for Acute Respiratory Distress Syndrome(ARDS)Constructing and developing bioprinters that utilize electrospraying and microfluidic techniquesWorking in an international lab abroadProgramming and constructing artificial intelligence systemsPerforming intravenous, intramuscular, and retro-orbital injections, organ harvests, nebulized LPS administrations, Bronchoalveolar Lavage (BAL) and Tissue Harvests, and IVC blood draws on murine modelsMaintaining tissue cultures and cell culturesMaintaining mouse breeding colonies including colonies with genetically modified, immunocompromised miceProducing nanoparticles with different formulations using various extrusion techniques and conjugating antibodies to them with different targeting moieties to use for in-vivo studiesPerformed a broad range of experiments in nanomedicine, pharmacology, and mouse work. The methods include producing and characterizing drug-loaded nanoparticles; pharmacological biodistribution experiments, and injecting our nanomedicines into mouse models of ARDS, such as intra-tracheal LPS followed, by organ harvest within 24 hours to determine ARDS phenotypes and drug side effects, as well as much more!

Liam Chase's Current Company Details

PhD in Bioengineering Student at University of Pennsylvania
Liam Chase Work Experience Details
  • University Of Pennsylvania Perelman School Of Medicine
    Research Specialist
    University Of Pennsylvania Perelman School Of Medicine Jul 2021 - Jul 2024
    Philadelphia, Pennsylvania, United States
    • Project Leader: Developed a cost-effective screening assay for infusion reactions in mice during preclinical studies using artificial intelligence to track movement behavior resulting in a publication. (Chase LS et al., Automated measurement of distance-walked as a "sixth vital sign" for detecting infusion reactions during preclinical testing. International journal of pharmaceutics, 645, 123369.)• Co-Leader of Project: Collaborated with a pharmaceutical company to develop… Show more • Project Leader: Developed a cost-effective screening assay for infusion reactions in mice during preclinical studies using artificial intelligence to track movement behavior resulting in a publication. (Chase LS et al., Automated measurement of distance-walked as a "sixth vital sign" for detecting infusion reactions during preclinical testing. International journal of pharmaceutics, 645, 123369.)• Co-Leader of Project: Collaborated with a pharmaceutical company to develop nanomedicine-based therapeutics for Acute Respiratory Distress Syndrome (ARDS).• Co-Leader of Project: Investigated the impact of conjugation chemistry on antibody-targeted nanoparticles, revealing significant variations in complement activation and biodistribution. Developed novel solutions to mitigate complement activation, highlighting the importance of considering opsonins in conjugation chemistry for nanomedicine applications, resulting in a publication under review at ACS Nano.• Lab Manager: Coordinated the execution of the following types of experiments for all projects in the lab: small molecule drug loading into nanoparticles, protein modification and conjugation onto nanoparticles, animal models of ARDS and sepsis, protein transfections using DNA plasmids, murine surgeries including intravenous, intramuscular, and retro-orbital injections, organ harvests, nebulized LPS administrations, Bronchoalveolar Lavage (BAL) and Tissue Harvests, and IVC blood draws.• Colony Manager: In-charge of multiple mouse breeding colonies of genetically modified, immunocompromised mice. Show less
  • Temple University
    Project Manager For Automated Epidermis Electrosprayer For Skin Bioprinter
    Temple University Jan 2020 - May 2021
    Philadelphia, Pennsylvania, United States
    • Project Manager: Managed three other teammates and developed workflows for researching and designing novel ideas for the creation of skin constructs with fully vascularized hypodermal layers and physiologically accurate construction using extrusion bioprinting and electrospraying keratinocytes.• Designed a belt-driven linear actuator that positions an electrosprayer above constructs consisting of a layer of extruded gelatin containing adipocytes and seeded endothelial cells under a layer… Show more • Project Manager: Managed three other teammates and developed workflows for researching and designing novel ideas for the creation of skin constructs with fully vascularized hypodermal layers and physiologically accurate construction using extrusion bioprinting and electrospraying keratinocytes.• Designed a belt-driven linear actuator that positions an electrosprayer above constructs consisting of a layer of extruded gelatin containing adipocytes and seeded endothelial cells under a layer of fibroblasts.• Modeled a chassis in Solidworks that allows a Nema 17 stepper motor attached to an A4988 Stepstick stepper motor driver wired to an Arduino Mega/RAMPS v1.4 to rotate a hex nut within a syringe pusher to supply mechanical pressure on the syringe for electrospraying keratinocytes.• Developed a cell viability assay protocol to ensure a full-thickness skin model consisted of a vascularized subcutaneous layer, a dermis, and an epidermis with correct cell morphology using staining. Show less
  • Istituto Italiano Di Tecnologia
    Visiting Researcher
    Istituto Italiano Di Tecnologia Jan 2021 - Apr 2021
    00161, Rome, Latium, Italy
    • Designed 3D printable microscope in PrusaSlicer, with a mechanical translation stage using Raspberry Pi.• Created an extrusion bioprinter to realize 3D models of biological skin and lung tissues by exploiting microfluidic techniques to improve the machine performance by integrating novel microfluidic tools at the extrusion nozzle.• Collaborated with the Nanotechnologies for Neurosciences Research Line of IIT to research microfluidic techniques for fiber spinning with international… Show more • Designed 3D printable microscope in PrusaSlicer, with a mechanical translation stage using Raspberry Pi.• Created an extrusion bioprinter to realize 3D models of biological skin and lung tissues by exploiting microfluidic techniques to improve the machine performance by integrating novel microfluidic tools at the extrusion nozzle.• Collaborated with the Nanotechnologies for Neurosciences Research Line of IIT to research microfluidic techniques for fiber spinning with international researchers. Show less
  • Orandasoft Llc
    Company Owner
    Orandasoft Llc Nov 2017 - Aug 2020
    Milton, Massachusetts, United States
    • Managed finances, employed 5 programmers, filed government forms, and created workflow plans.• Published and programmed multiple game apps on the Apple App Store using Objective C and Swift.• Released Swap Tiles which had a 4.9-star rating and over 60,000 downloads on the Apple App Store.

Liam Chase Education Details

Frequently Asked Questions about Liam Chase

What is Liam Chase's role at the current company?

Liam Chase's current role is PhD in Bioengineering Student at University of Pennsylvania.

What is Liam Chase's email address?

Liam Chase's email address is li****@****enn.edu

What schools did Liam Chase attend?

Liam Chase attended University Of Pennsylvania, University Of Pennsylvania, Temple University.

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