Liam Chase Email & Phone Number

Philadelphia, Pennsylvania, United States

• Project Leader: Developed a cost-effective screening assay for infusion reactions in mice during preclinical studies using artificial intelligence to track movement behavior resulting in a publication. (Chase LS et al., Automated measurement of distance-walked as a "sixth vital sign" for detecting infusion reactions during preclinical testing. International journal of pharmaceutics, 645, 123369.)• Co-Leader of Project: Collaborated with a pharmaceutical company to develop… Show more • Project Leader: Developed a cost-effective screening assay for infusion reactions in mice during preclinical studies using artificial intelligence to track movement behavior resulting in a publication. (Chase LS et al., Automated measurement of distance-walked as a "sixth vital sign" for detecting infusion reactions during preclinical testing. International journal of pharmaceutics, 645, 123369.)• Co-Leader of Project: Collaborated with a pharmaceutical company to develop nanomedicine-based therapeutics for Acute Respiratory Distress Syndrome (ARDS).• Co-Leader of Project: Investigated the impact of conjugation chemistry on antibody-targeted nanoparticles, revealing significant variations in complement activation and biodistribution. Developed novel solutions to mitigate complement activation, highlighting the importance of considering opsonins in conjugation chemistry for nanomedicine applications, resulting in a publication under review at ACS Nano.• Lab Manager: Coordinated the execution of the following types of experiments for all projects in the lab: small molecule drug loading into nanoparticles, protein modification and conjugation onto nanoparticles, animal models of ARDS and sepsis, protein transfections using DNA plasmids, murine surgeries including intravenous, intramuscular, and retro-orbital injections, organ harvests, nebulized LPS administrations, Bronchoalveolar Lavage (BAL) and Tissue Harvests, and IVC blood draws.• Colony Manager: In-charge of multiple mouse breeding colonies of genetically modified, immunocompromised mice. Show less

Philadelphia, Pennsylvania, United States

• Project Manager: Managed three other teammates and developed workflows for researching and designing novel ideas for the creation of skin constructs with fully vascularized hypodermal layers and physiologically accurate construction using extrusion bioprinting and electrospraying keratinocytes.• Designed a belt-driven linear actuator that positions an electrosprayer above constructs consisting of a layer of extruded gelatin containing adipocytes and seeded endothelial cells under a layer… Show more • Project Manager: Managed three other teammates and developed workflows for researching and designing novel ideas for the creation of skin constructs with fully vascularized hypodermal layers and physiologically accurate construction using extrusion bioprinting and electrospraying keratinocytes.• Designed a belt-driven linear actuator that positions an electrosprayer above constructs consisting of a layer of extruded gelatin containing adipocytes and seeded endothelial cells under a layer of fibroblasts.• Modeled a chassis in Solidworks that allows a Nema 17 stepper motor attached to an A4988 Stepstick stepper motor driver wired to an Arduino Mega/RAMPS v1.4 to rotate a hex nut within a syringe pusher to supply mechanical pressure on the syringe for electrospraying keratinocytes.• Developed a cell viability assay protocol to ensure a full-thickness skin model consisted of a vascularized subcutaneous layer, a dermis, and an epidermis with correct cell morphology using staining. Show less

00161, Rome, Latium, Italy

• Designed 3D printable microscope in PrusaSlicer, with a mechanical translation stage using Raspberry Pi.• Created an extrusion bioprinter to realize 3D models of biological skin and lung tissues by exploiting microfluidic techniques to improve the machine performance by integrating novel microfluidic tools at the extrusion nozzle.• Collaborated with the Nanotechnologies for Neurosciences Research Line of IIT to research microfluidic techniques for fiber spinning with international… Show more • Designed 3D printable microscope in PrusaSlicer, with a mechanical translation stage using Raspberry Pi.• Created an extrusion bioprinter to realize 3D models of biological skin and lung tissues by exploiting microfluidic techniques to improve the machine performance by integrating novel microfluidic tools at the extrusion nozzle.• Collaborated with the Nanotechnologies for Neurosciences Research Line of IIT to research microfluidic techniques for fiber spinning with international researchers. Show less

Milton, Massachusetts, United States

• Managed finances, employed 5 programmers, filed government forms, and created workflow plans.• Published and programmed multiple game apps on the Apple App Store using Objective C and Swift.• Released Swap Tiles which had a 4.9-star rating and over 60,000 downloads on the Apple App Store.

Doctor Of Philosophy - Phd, Bioengineering And Biomedical Engineering

The first doctorate degree in bioengineering in the nation was awarded at Penn in 1953, and since that time, Penn Bioengineering has been.

Master Of Science In Engineering, Bioengineering

The Bioengineering master’s program provides an interdisciplinary education in scientific and engineering fundamentals, with an emphasis.

Bachelor Of Science In Bioengineering, Bioengineering And Biomedical Engineering

Activities and Societies: Biomedical Engineering Society Bioengineering Major | Chemistry Minor | Cellular Engineering Concentration