Lorène Crespin (Cazaux-Lerou) Email & Phone Number

Toulouse, Occitanie, France

- (Co) Lead chemist on several projects in the field of oncology and inflammatory diseases: supervision of up to 10 chemists, in charge of the chemistry program (synthesis of compounds from 10 mg to 20 g), SAR analysis and optimisation of ADME/PhysChem properties, presentation to the client, design of the molecules. One project led to a patent in collaboration with Dark Blue Therapeutics.- In charge of projects for hit expansion, hit to lead and lead optimisation stages.- Analysis and… Show more - (Co) Lead chemist on several projects in the field of oncology and inflammatory diseases: supervision of up to 10 chemists, in charge of the chemistry program (synthesis of compounds from 10 mg to 20 g), SAR analysis and optimisation of ADME/PhysChem properties, presentation to the client, design of the molecules. One project led to a patent in collaboration with Dark Blue Therapeutics.- In charge of projects for hit expansion, hit to lead and lead optimisation stages.- Analysis and reporting to the client of HTS.- Team leader: management of 3 chemists (1 technician and 2 master levels).- Medchem trainer for the medicinal chemistry course fundamental level within the compagny: preparation of the content of the formation and presentation to the chemists of Evotec. Show less

Toulouse

- Co chemistry lead on an oncology project from hit to lead to lead optimisation and designation of a the preclinical drug candidate: supervision of up to 10 chemists, project management, presentation to the client, in charge of the chemistry program (synthesis of compounds from 10 mg to 5 g), analysis of the SAR and optimisation of the ADME/PhysChem properties. This project led to a patent in collaboration with Escientia and EXS73565 is currently in IND enabling stage.- Efficient… Show more - Co chemistry lead on an oncology project from hit to lead to lead optimisation and designation of a the preclinical drug candidate: supervision of up to 10 chemists, project management, presentation to the client, in charge of the chemistry program (synthesis of compounds from 10 mg to 5 g), analysis of the SAR and optimisation of the ADME/PhysChem properties. This project led to a patent in collaboration with Escientia and EXS73565 is currently in IND enabling stage.- Efficient contribution on 5 different projects (mainly oncology).- Team Leader: management of 2 master level chemists.- Leader of the photochemistry working group: development of the photochemistry field within the compagny. Show less

Région De Toulouse, France

- Area of expertise: ADC (Antibody Drug Conjugate).- Handling and synthesis of hazardous and toxic compounds (OEB5 and OEB6 compounds): manipulation using an isolator and specific equipments to insure safety of the operators.- Supervision of one technician.

Cambridge, Royaume-Uni

Research associate in the group of Prof. Steven V. Ley (Whiffen Lab) at the University of Cambridge. Fellowship funded by Pfizer (Medicinal Chemistry Initiative Programme)- Development of new methodologies to access scaffolds with a therapeutic interest such as 1,2,4-triazines.- Photoredox and photo-radical reactions for the synthesis of heterocycles in batch and flow reactors.- Photolysis in flow reactor for the synthesis of highly instable intermediates.- Each of the… Show more Research associate in the group of Prof. Steven V. Ley (Whiffen Lab) at the University of Cambridge. Fellowship funded by Pfizer (Medicinal Chemistry Initiative Programme)- Development of new methodologies to access scaffolds with a therapeutic interest such as 1,2,4-triazines.- Photoredox and photo-radical reactions for the synthesis of heterocycles in batch and flow reactors.- Photolysis in flow reactor for the synthesis of highly instable intermediates.- Each of the projects led to a publication (3 in total in J. Org. Chem., Org. Lett. and Chem. Commun.).- In charge of the safety introduction for new lab members.- Supervision of students for M2 to PhD. Show less

Région De Grenoble, France

Département de Chimie Moléculaire, team SeRCO (Synthèse et Réactivité en Chimie Organique) PhD project : Total synthesis of Lycorine-type alkaloids by tandem metathesisAdvisors : Prof. Jean-Francois Poisson and Dr. Sébastien Carret- Development of an innovative pathway for the total synthesis of Lycorine-type alkaloids (Lycorine, Siculinine, ...)- Total synthesis of 3 Lycoranes via diastereoselective reactions- Towards the total synthesis of Fortucine and… Show more Département de Chimie Moléculaire, team SeRCO (Synthèse et Réactivité en Chimie Organique) PhD project : Total synthesis of Lycorine-type alkaloids by tandem metathesisAdvisors : Prof. Jean-Francois Poisson and Dr. Sébastien Carret- Development of an innovative pathway for the total synthesis of Lycorine-type alkaloids (Lycorine, Siculinine, ...)- Total synthesis of 3 Lycoranes via diastereoselective reactions- Towards the total synthesis of Fortucine and Kirkine- Supervision of Bachelor, MSc. level trainees Show less

Basel Und Umgebung, Schweiz

Pharma Research and Early Development department - F. Hoffmann - La Roche, BaselAdvisor : Dr. Emmanuel PinardProject : Multi-step synthesis of heterocycles through palladium-catalyzed coupling for the treatement of a central nervous system disease.

Région De Basel , Suisse

Discovery Chemistry Department - Novartis, BaselAdvisor : Dr. Richard HengProject : Heterocyclic chemistry and syntesis of derivatized aminoacids in the team of auto-immune and inflammatory diseases. Synthesis and characterization of molecules for the lead optimisation.

Montpellier, France

Advisors : Dr. Zohra Benfodda and Prof. Patrick MeffreProject : medicinal chemistry project for the synthesis of new ligands for glutamade metabotropic receptors. Multi-step syntheses of aminoacid derivatives.

Région De Montpellier, France

Advisor : Prof. Jean-Louis MonteroProject : synthesis of oligosaccharides with therapeutic interest. Development of a multi-step synthetic approach to a trisaccharide.

Mooc Project Management

A Massive Open Online Course MOOC is an online course aimed at unlimited participation and open access via the web. This MOOC aim was.

Doctor Of Philosophy (Phd) In Organic Chemistry

Diplome D'Ingenieur Chimiste, Organic Chemistry, 1St In A 100-Student Class, Distinction With The “Total Chaire”

"Diplôme d'ingénieur chimiste" is the equivalent to an Honour Master Degree, performed at the Graduate School of Chemistry of Montpellier.

Research Master'S Degree, Biomolecules Engineering And Organic Chemistry

M1 Biomolecular Chemistry, Organic Chemistry

Bachelor Of Science In Chemistry, General Chemistry