Lucas Faustino, Ph.D. Email & Phone Number

Cambridge, MA, United States

Cambridge, MA, United States

Cambridge, MA, United States

• R&D – Immune Cell Redirection and Overcoming Immunosuppression, Oncology
• Oversight cross-functional team for a preclinical immuno-oncology program, overseeing target validation, PoC and MoA studies.
• Research and development of novel immuno-oncology therapeutic strategies (biologics) for innate and adaptive lymphocytes in TME.
• Manage two senior scientists, providing transparent feedback and fostering individual growth while emphasizing teamwork to achieve organizational goals.
• Champion external collaboration with academic partner institutions through the organizational Innovation Awards (iAwards) program to advance cutting-edge therapeutic solutions.

Boston, MA, United States

• Academic appointment: Junior Faculty
• Supervised a research technician and a postdoctoral fellow in immunology projects related to type 2 immunity and asthma therapy.
• Participated as speaker at national and international scientific conferences.
• Contributed as Ad hoc reviewer of immunology scientific journals

Boston, MA, United States

• T-cell and innate lymphocyte biology in respiratory diseases
• Conducted research focused on innate and adaptive immune mechanisms surrounding IL-33 axis in asthma and influenza virus infection, aiming to develop more effective therapeutic interventions.
• Led preclinical mouse studies in partnership with pharmaceutical companies to define the transcriptional program of tissue-resident memory T cells in asthma, seeking for novel therapeutic targets.
• Wrote proposals for the NIH R01 (a five-year grant) and the Sanofi iAwards (a one-year grant), both successfully awarded in 2022. The major goal of these projects was to investigate the mechanisms of Treg cell.

Boston, MA, United States

• Mentor: Dr. Andrew D. Luster, M.D., Ph.D.
• Conducted clinical research by analyzing bronchoalveolar lavage (BAL) specimens from allergic subjects with and without asthma to determine differences in airway immune responses to allergen challenges that may be.
• Investigated the IL-33–Treg axis in the regulation of pulmonary innate immunity. This study uncovered a novel fundamental function of tissue Treg cells in suppressing γδ T cell responses to lung injury in allergy and.
• Designed clinically relevant asthma models for common environmental allergens that have become standard for all laboratory asthma studies.
• Awarded the Tosteson & Fund for Medical Discovery (FMD) Awards in 2015 to investigate the IL-23–IL-33 axis in asthma.
• Investigated the mechanisms of leukocyte trafficking in cerebral malaria that leads to lethal neuropathological syndrome, contributing to a deeper understanding of the disease pathogenesis.

Sao Paulo, Brazil

• Mentor: Dr. Momtchilo Russo, M.D., Ph.D.
• Investigated the role of TGF-β, PD-1, FasL, and TRAIL in pulmonary inflammation. This study identified TRAIL as a key inhibitory molecule in reducing allergic airway inflammation to chronic allergen challenges.
• Awarded the National Council for Scientific and Technological Development (CNPq) Fellowship Awards in 2012 to develop research abroad.

Doctor Of Philosophy (Ph.D.), Immunology

Thesis title: Role of regulatory T cells in asthma Mentor: Dr. Momtchilo Russo, M.D., Ph.D. • Investigated the mechanisms underlying the.

Bachelor Of Science (B.Sc.), Biological Sciences

Mentor: Dr. Antenor A. Santos, Ph.D. • Participated in multidisciplinary research to investigate the phagocytic activity of macrophages.