Lucas Faustino, Ph.D. Email & Phone Number

Cambridge, Ma, United States

Cambridge, Ma, United States

Cambridge, Ma, United States

R&D – Immune Cell Redirection and Overcoming Immunosuppression, Oncology• Oversight cross-functional team for a preclinical immuno-oncology program, overseeing target validation, PoC and MoA studies.• Research and development of novel immuno-oncology therapeutic strategies (biologics) for innate and adaptive lymphocytes in TME. • Manage two senior scientists, providing transparent feedback and fostering individual growth while emphasizing teamwork to achieve organizational goals.• Champion external collaboration with academic partner institutions through the organizational Innovation Awards (iAwards) program to advance cutting-edge therapeutic solutions.

Boston, Ma, United States

Academic appointment: Junior Faculty• Supervised a research technician and a postdoctoral fellow in immunology projects related to type 2 immunity and asthma therapy.• Participated as speaker at national and international scientific conferences.• Contributed as Ad hoc reviewer of immunology scientific journals

Boston, Ma, United States

T-cell and innate lymphocyte biology in respiratory diseases• Conducted research focused on innate and adaptive immune mechanisms surrounding IL-33 axis in asthma and influenza virus infection, aiming to develop more effective therapeutic interventions.• Led preclinical mouse studies in partnership with pharmaceutical companies to define the transcriptional program of tissue-resident memory T cells in asthma, seeking for novel therapeutic targets.• Wrote proposals for the NIH R01 (a five-year grant) and the Sanofi iAwards (a one-year grant), both successfully awarded in 2022. The major goal of these projects was to investigate the mechanisms of Treg cell persistence and function in allergic lungs to develop new therapeutic strategies for asthma.

Boston, Ma, United States

Mentor: Dr. Andrew D. Luster, M.D., Ph.D.• Conducted clinical research by analyzing bronchoalveolar lavage (BAL) specimens from allergic subjects with and without asthma to determine differences in airway immune responses to allergen challenges that may be related to the development of asthma.• Investigated the IL-33–Treg axis in the regulation of pulmonary innate immunity. This study uncovered a novel fundamental function of tissue Treg cells in suppressing γδ T cell responses to lung injury in allergy and infection.• Designed clinically relevant asthma models for common environmental allergens that have become standard for all laboratory asthma studies.• Awarded the Tosteson & Fund for Medical Discovery (FMD) Awards in 2015 to investigate the IL-23–IL-33 axis in asthma.• Investigated the mechanisms of leukocyte trafficking in cerebral malaria that leads to lethal neuropathological syndrome, contributing to a deeper understanding of the disease pathogenesis. • Assisted in compiling Institutional Animal Care & Use Committee (IACUC) protocols for approval.

Sao Paulo, Brazil

Mentor: Dr. Momtchilo Russo, M.D., Ph.D.• Investigated the role of TGF-β, PD-1, FasL, and TRAIL in pulmonary inflammation. This study identified TRAIL as a key inhibitory molecule in reducing allergic airway inflammation to chronic allergen challenges.• Awarded the National Council for Scientific and Technological Development (CNPq) Fellowship Awards in 2012 to develop research abroad.

Doctor Of Philosophy (Ph.D.), Immunology

Thesis title: Role of regulatory T cells in asthma Mentor: Dr. Momtchilo Russo, M.D., Ph.D. • Investigated the mechanisms underlying.

Bachelor Of Science (B.Sc.), Biological Sciences

Mentor: Dr. Antenor A. Santos, Ph.D. • Participated in multidisciplinary research to investigate the phagocytic activity of macrophages.