Mario De Lucio, Ph.D. Email & Phone Number

Indianapolis, In, Us

West Lafayette, Indiana, United States

◦ Engaged in a strategic collaboration between Eli Lilly and Purdue University, concentrating on the analysis and optimization of injectable medicine delivery systems.◦ Conducted advanced numerical simulations to enhance understanding of the auto-injection process mechanics, aiming to improve drug bioavailability, minimize injection site pain, and boost patient compliance and overall health.◦ Explored innovative approaches and technologies for improving drug delivery systems, focusing on device design, injection parameters, and drug formulation.◦ Demonstrated expertise in advanced computational methods, quantitative analysis, Bayesian and causal inference modeling, and AI methods in health and life sciences.◦ Contributed to research grant writing, project management, and publication in reputable healthcare, medical, and biomedical journals.

West Lafayette

◦ Involved in a project within a strategic collaboration between Eli Lilly and Purdue University, focusingon the analysis of the delivery of injectable medicines.◦ Performed numerical simulations to analyze the delivery of injectable medicines with the overall goals of better understanding the fundamental mechanics of the auto-injection process and its effect on skin,improved drug bioavailability, and reducing injection site pain in order to better patient compliance andenhance overall health.◦ Developed high-fidelity computational models to understand and predict tissue deformation and fluid pressure build-up as well as their impact on drug transport and absorption.◦ Investigated innovative approaches and technologies to improve drug delivery systems, considering factors such as device design, injection parameters, and drug formulation.◦ Supported the strategic collaboration between Eli Lilly and Purdue University, fostering innovation andfacilitating the translation of research findings into practical applications in the pharmaceutical industry

West Lafayette, Indiana

◦ Developed computational methods utilizing isogeometric analysis, poroelasticity, and data-driven tissue geometries to model the complex dynamics of high-volume, high-speed subcutaneous injection of monoclonal antibodies.◦ Developed highly sophisticated numerical algorithms capable of running in parallel, utilizing 200+ processors in Purdue’s Rosen Center for Advanced Computing.◦ Leveraged the computational power and parallel processing capabilities to efficiently simulate andanalyze the complex fluid-structure interactions during the subcutaneous injection process.◦ Conducted extensive simulations using the developed computational methods to investigate the effects of injection parameters, tissue properties, and geometrical variations on the injection dynamics and the resulting distribution of monoclonal antibodies

Trondheim Area, Norway

◦ Acted as a main collaborator in the project “Industrial Implementation of 3D printed AlSi10Mg components under quasi-static loading”.◦ Conducted experimental tests on structures under both quasi-static and dynamic conditions, specifically focusing on extreme deformations and crushing.◦ Utilized Digital Image Correlation (DIC) tools to postprocess experimental results, enabling precise measurements and analysis of structural behavior.◦ Applied crashworthiness optimization techniques to enhance the performance and efficiency of thestructures.◦ Developed finite element models to simulate the behavior of aluminum alloy thin-walled structures.◦ Collaborated closely with industry partners to ensure the successful implementation of 3D printedcomponents under quasi-static loading.

◦ Awarded a prestigious fellowship by the Spanish Ministry of Education and Science to serve as aprincipal investigator, collaborating with the Department of Cardiovascular Surgery at the ComplejoUniversitario Hospitalario de A Coruna (CHUAC), to conduct research on the risk of rupture ofabdominal aortic aneurysms (AAA) with atherosclerotic intimal thickening.◦ Developed an in-house code, called AneuPy, to generate idealized geometrical models of AAAs usingclinical data. This code facilitated the creation of accurate and representative computational models forfurther analysis AneuPy.◦ Performed cardiovascular fluid-structure interaction simulations of AAAs using different constitutivemodels for aortic tissue that allowed to better determine the risk of rupture.◦ Analyzed the stress distribution, deformation patterns, and hemodynamic factors within the AAA models to gain insights into the potential mechanisms of rupture.◦ Collaborated closely with the Department of Cardiovascular Surgery at CHUAC, exchanging knowledgeand expertise to bridge the gap between research and clinical applications.

A Coruña, Galicia, Spain

◦ Granted with a research scholarship from the University of A Coruna to conduct research under theproject “Mechanical Characterization of Structural Adhesives for Crashworthiness Applications”.◦ Analyzed the mechanical behavior of various structural adhesives through rigorous experimental tests.◦ Developed a computational model to accurately reproduce the structural behavior of the adhesives.◦ Incorporated experimental data into the computational model, enabling precise predictions of adhesive performance under different loading conditions.◦ Successfully replicated the adhesive’s structural behavior in the computational model, validating thequality of the mechanical characterization.◦ Provided engineers and researchers with a reliable tool for assessing adhesive performance and optimizing their use in various industries.

Santander Area, Spain

◦ Worked as a hydraulic modeler on large-scale flood management projects in Panama and Venezuela incollaboration with the World Bank and the Inter-American Development Bank.◦ Conducted two and three-dimensional numerical simulations of free surface flow in rivers and estuaries to assess and quantify the level of flood hazard in densely populated urban areas.◦ Utilized advanced numerical models to assess the level of flood hazard and create accurate flood riskmaps, providing valuable information for urban planning and disaster management strategies.◦ Generated accurate flood risk maps by analyzing the hydraulic behavior of water bodies, consideringfactors such as water flow, topography, and urban infrastructure.◦ Designed and proposed innovative solutions including flood barriers, coastal defenses, waterfront parks, flood-resilient buildings and landscapes, reducing flood hazards by up to 60%.◦ Conducted feasibility studies and cost-benefit analyses to evaluate the economic and environmentalimplications of proposed flood mitigation solutions, assisting decision-makers in selecting the mostsuitable approaches.

Doctor Of Philosophy - Phd, Mechanical Engineering

Activities and Societies: Society of Hispanic Professional Engineers, Purdue Judo Club, Purdue Salsa Club. Concentration: Solid Mechanics.

Master Of Science - Ms, Civil Engineering (Ingeniero De Caminos, Canales Y Puertos), First Class Honors

Activities and Societies: Structural Mechanics Group (GME), Student Representative and member of the Advisory Committee. Award.

Bachelor Of Science - Bs, Civil Engineering (Ingeniero Técnico De Obras Públicas), First Class Honors

Activities and Societies: Structural Mechanics Group (GME), Construction Engineering Group (gCons), Student Representative Award.

Bachillerato, Ciencias Y Tecnología

Graduated in a French bilingual program (Comenius Programme)